Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Nature Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/79109PMID 10973265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Signs of Alzheimer’s Disease: Tied to Aging

  2025cites this paper
• An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

  2021cites this paper
• Selective Autophagy Pathway of Nanoparticles and Nanodrugs: Drug Delivery and Pathophysiological Effects

  2020cites this paper
• Immune Signaling in Neurodegeneration.

  2019cites this paper
• A Snapshot on the Current Status of Alzheimer's Disease, Treatment Perspectives, In-Vitro and In-Vivo Research Studies and Future Opportunities.

  2019cites this paper
• Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

  2018cites this paper
• Investigating the neuroprotective role of OGA inhibition by Thiamet-G against Alzheimer\'s disease

  2018influential citation
• Neurodegenerative disease mechanisms induced by tau fragmentation in a novel model of human tauopathy

  2018cites this paper
• Mitochondrial dysfunction and the role of Mitophagy in Alzheimer ’ s Disease 1 MedDocs eBooks

  2018cites this paper
• Targeting the Hsp90/Aha1 Complex for the Treatment of Tauopathies

  2018cites this paper
• Acute and chronic effects of systemic inflammation on P301S tau mouse model of neurodegeneration

  2018cites this paper
• Investigating therapeutic strategies in a preclinical model for Alzheimer's disease

  2017cites this paper
• iii CHARACTERIZING rTg 4510 MICE MODEL OF ALZHEIMER ’ S DISEASE ON ADULT NEUROGENESIS AND COGNITIVE FUNCTION by Team Dream

  2017influential citation
• Chapter 6 Pin 1 Protects Against Alzheimer ' s Disease : One Goal , Multiple Mechanisms

  2017cites this paper
• Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein

  2017cites this paper
• Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy

  2017cites this paper
• EFFECTS OF THE NOVEL IDO INHIBITOR DWG-1036 ON THE BEHAVIOUR AND NEUROCHEMISTRY OF THE TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE

  2017cites this paper
• Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit

  2017cites this paper
• Investigating the contribution of astrocytes and neuroinflammation to pathological tau changes in Alzheimer's disease

  2017cites this paper
• Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

  2017cites this paper
• Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease

  2016cites this paper
• DEPLETION OF TDP-43 ACCELERATES NEURODEGENERATION IN AN ALZHEIMER’S MOUSE MODEL, INDEPENDENT OF BETA-AMYLOID PLAQUE BURDEN

  2016cites this paper
• Understanding Alzheimer’s disease in Hong Kong: can regular retinal checkups be used to diagnose, monitor and study disease pathogenesis?

  2016cites this paper
• Brain-Derived Neurotrophic Factor’s Neuroprotective Effects in Entorhinal Cortex

  2016cites this paper
• Susceptibility genes and phenotype modifiers in prion diseases

  2016cites this paper
• Molecular and Functional Evidence of Alzheimer's Disease in The Eye: Experimental and Clinical Application

  2016cites this paper
• Basic aspects in selecting a suitable transgenic rodent model for Alzheimer's disease.

  2015cites this paper
• Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission

  2015cites this paper
• Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

  2015cites this paper
• Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice

  2015cites this paper
• Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity.

  2015cites this paper
• FTD and ALS—translating mouse studies into clinical trials

  2015cites this paper
• Factors de risc en la malaltia d’Alzheimer: Estudis en animals triple transgènics 3xTg-AD

  2014cites this paper
• Plant-based vaccines for Alzheimer's disease: an overview

  2014cites this paper
• Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis

  2013cites this paper
• Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent

  2013cites this paper
• Mouse models for the investigation of MAPT and its role in neurodegenerative disease

  2013influential citation
• Progress in Frontotemporal Dementia Research

  2013cites this paper
• Tau aggregates as immunotherapeutic targets.

  2013influential citation
• Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

  2013cites this paper
• Pathology of clinical and preclinical Alzheimer’s disease

  2013cites this paper
• Tau Triage Decisions Mediated by the Chaperone Network

  2012cites this paper
• rug pipeline in neurodegeneration based on transgenic mice models of lzheimer ’ s disease

  2012cites this paper
• Activation of PARP by Oxidative Stress Induced by β-Amyloid: Implications for Alzheimer’s Disease

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer ’ s disease

  2012cites this paper
• PET applications in animal models of neurodegenerative and neuroinflammatory disorders.

  2012cites this paper
• Effects of NK-4, a Cyanine Dye with Antioxidant Activities: Attenuation of Neuronal Deficits in Animal Models of Oxidative Stress-Mediated Brain Ischemia and Neurodegenerative Diseases

  2012cites this paper
• Recent rodent models for Alzheimer’s disease: clinical implications and basic research

  2012influential citation
• Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration

  2012cites this paper
• 11 Pin 1 : A New Enzyme Pivotal for Protecting Against Alzheimer ’ s Disease

  2012cites this paper
• Using Drosophila to study the contribution of human kinases to tau toxicity

  2012cites this paper
• Design, Synthese und Optimierung von GSK-3-Inhibitoren und ihre Evaluation in Modellen der Alzheimer-Demenz

  2012cites this paper
• Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspects.

  2011cites this paper
• Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.

  2011influential citation
• Biomarker-based dissection of neurodegenerative diseases.

  2011cites this paper
• Etude du mécanisme d’agrégation de la protéine Tau et son inhibition par des composés polyphénoliques

  2011cites this paper
• Endoplasmic reticulum stress induces tau pathology and forms a 1 vicious cycle : Implication in Alzheimer ’ s disease pathogenesis 2 3

  2011cites this paper
• NON-INVASIVE EVALUATION OF TAU TARGETED IMMUNOTHERAPY : A TRACT-TRACING BOLUS MEMRI STUDY

  2011cites this paper
• Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis.

  2010influential citation
• Immunohistochemical Features of Dystrophic Axons in Papillon Dogs with Neuroaxonal Dystrophy

  2009cites this paper
• P2‐534: Efficacy of a novel, orally active GSK‐3 Inhibitor 6‐Methyl‐N‐[3‐[[3‐(1‐methylethoxy)propyl]carbamoyl]‐1H‐pyrazol‐4‐yl]pyridine‐3‐carboxamide in tau transgenic mice

  2009cites this paper
• Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.

  2009cites this paper
• Central Role of Tau Protein in Alzheimer»S Disease and Related Tauopathies

  2009cites this paper
• Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models

  2009cites this paper
• Biological transgenic mouse models of Alzheimer's disease.

  2008cites this paper
• Motor assessment in transgenic Tau mice

  2008cites this paper
• Other degenerative processes.

  2007cites this paper
• Up-regulation of tau, a brain microtubule- associated protein, in lens cortical fractions of aged αA-, αB-, and αA/B-crystallin knockout mice

  2007cites this paper
• Role of tau in Alzheimer's dementia and other neurodegenerative diseases

  2007cites this paper
• Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1.

  2006cites this paper
• Étude des mécanismes moléculaires impliqués dans la mort neuronale induite par le peptide de ß-amyloïde soluble : recherche et validation fonctionnelle de cibles cellulaires

  2006cites this paper
• Implication de la protéine tau dans la dégénérescence neuronale in vitro

  2006influential citation
• Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.

  2006cites this paper
• Interactions of volatile anesthetics with neurodegenerative-disease-associated proteins.

  2006cites this paper
• Tau Alternative Splicing and Frontotemporal Dementia

  2005cites this paper
• PHOSPHORYLATION AND SEQUENCE DEPENDENCY OF NEUROFILAMENT PROTEIN OXIDATIVE MODIFICATION IN ALZHEIMER DISEASE

  2005cites this paper
• NSAIDs, fatty acids and cholesterol as modifiers of pathology in rodent models of Alzheimer's disease

  2004cites this paper
• Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy

  2004cites this paper
• TRANSGENIC MICE EXPRESSING WILD-TYPE TAU TRANSGENES

  2004cites this paper
• Transgenic Mice Model in Alzheimer's Disease

  2002cites this paper
• Tau function and dysfunction in neurons

  2002cites this paper
• Book Review: Iron and Parkinson’s Disease

  2002cites this paper
• Cytoskeletal mechanisms of neuronal degeneration

  2001cites this paper
• Functional genomics of the Down syndrome.

  2001cites this paper