Abstract This research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy human volunteers. Twenty healthy volunteers received Loratadine 10-mg, Fexofenadine 120-mg, Meclizine 50-mg, Chlorpheniramine Maleate 4-mg, and Placebo 250-mg starch tablet in a five-way crossover, double-blind study. Following each dose the participants were subjected to take a series of test of cognitive functions and psychomotor performances at defined interval. A certain amount of washout period was also maintained for each drug. The test battery included PennCNP—Full Battery Test, Psychology Experiment Building Language, Stanford Sleepiness Scale, and Brief Mood Introspection Scale. The test results These test results were analyzed by one-way and two-way ANOVAs. In general, antihistamines didn't show any statistically significant deviation from that of placebo. However, slight improvement was observed in word memory test (Both immediate and delayed) by Chlorpheniramine; although it increased the reaction time in visual object learning test. Fexofenadine also increased performance in delayed word memory test. Meclizine showed significant reduction (p < 0.05) of reaction time in line orientation task. The subjects receiving Loratadine reported slightly unpleasant mood then control group. This study will contribute to choose antihistamine rightly maximizing the productivity; minimizing the losses of working hours and daytime in school and workplaces. Right options of antihistamines will make wider flexibility for the people needed sharp motor functioning to work in factory with life-threatening machineries achieving less sedation and psychomotor unimpairment.
Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers
Rawshan Zannat,M. Uddin,M. Rahman,J. Aklima,M. Al Amin
Published 2016 in Cogent Psychology
ABSTRACT
PUBLICATION RECORD
- Publication year
2016
- Venue
Cogent Psychology
- Publication date
2016-08-12
- Fields of study
Medicine, Psychology
- Identifiers
- External record
- Source metadata
Semantic Scholar
CITATION MAP
EXTRACTION MAP
CLAIMS
CONCEPTS
- antihistamines
The set of H1-antihistamine drugs evaluated in the volunteer crossover trial, including loratadine, fexofenadine, meclizine, and chlorpheniramine.
Aliases: H1 antihistamines
- chlorpheniramine
A first-generation antihistamine tested as chlorpheniramine maleate at a 4 mg dose in the crossover regimen.
Aliases: Chlorpheniramine Maleate, Chlorpheniramine Maleate 4 mg
- cognitive and psychomotor testing
The battery of executive-function, memory, attention, sleepiness, mood, and reaction-time tasks used after each dose.
Aliases: test battery, cognitive tests, psychomotor tests
- fexofenadine
A second-generation antihistamine tested at a 120 mg dose in the crossover regimen.
Aliases: Fexofenadine 120 mg
- loratadine
A second-generation antihistamine tested at a 10 mg dose in the crossover regimen.
Aliases: Loratadine 10 mg
- meclizine
A first-generation antihistamine tested at a 50 mg dose in the crossover regimen.
Aliases: Meclizine 50 mg
- mood
Subjective emotional state measured in the session with the Brief Mood Introspection Scale.
Aliases: emotional state, affect
- placebo
The starch-tablet control condition used for comparison in the blinded crossover design.
Aliases: control, starch tablet
REFERENCES
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