Spontaneous and evoked pain-associated behaviors in a rat model of neuropathic pain respond differently to drugs with different mechanisms of action.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Pharmacology, Biochemistry and Behavior

• Publication date

  2016-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.pbb.2015.11.008PMID 26597514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effects of dexmedetomidine alone and in combination with tramadol or amitriptyline in a neuropathic pain model.

  2014cited by this paper
• AS1069562, the (+)-Isomer of Indeloxazine, Exerts Analgesic Effects in a Rat Model of Neuropathic Pain with Unique Characteristics in Spinal Monoamine Turnover

  2014influential reference
• Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms

  2013cited by this paper
• The evidence for pharmacologic treatment of neuropathic cancer pain: beneficial and adverse effects.

  2013cited by this paper
• Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord.

  2012cited by this paper
• Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist.

  2012cited by this paper
• Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain

  2012cited by this paper
• Post-injury repeated administrations of minocycline improve the antinociceptive effect of morphine in chronic constriction injury model of neuropathic pain in rat.

  2012cited by this paper
• Elucidation of pathophysiology and treatment of neuropathic pain.

  2012cited by this paper
• Automated measurement of spontaneous pain‐associated limb movement and drug efficacy evaluation in a rat model of neuropathic pain

  2012cited by this paper
• Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy

  2011cited by this paper
• Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.

  2010cited by this paper
• NEUROPATHIC PAIN : REDEFINITION AND A GRADING SYSTEM FOR CLINICAL AND RESEARCH PURPOSES. Author's reply

  2009cited by this paper
• NEUROPATHIC PAIN: REDEFINITION AND A GRADING SYSTEM FOR CLINICAL AND RESEARCH PURPOSES

  2009cited by this paper
• Pharmacological characterization of standard analgesics on mechanical allodynia in streptozotocin-induced diabetic rats.

  2009cited by this paper
• The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand Pregabalin

  2009cited by this paper
• The Efficacy of the AMPA Receptor Antagonist NS1209 and Lidocaine in Nerve Injury Pain: A Randomized, Double-Blind, Placebo-Controlled, Three-Way Crossover Study

  2009cited by this paper
• Faculty Opinions recommendation of The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.

  2009cited by this paper
• Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.

  2008cited by this paper
• Neuropathic pain

  2008cited by this paper
• Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)

  2008cited by this paper
• Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain

  2008cited by this paper
• Preclinical Assessment of Candidate Analgesic Drugs: Recent Advances and Future Challenges

  2006cited by this paper
• EFNS guidelines on pharmacological treatment of neuropathic pain

  2006cited by this paper
• Pregabalin: From molecule to medicine.

  2006cited by this paper
• The use of topical diclofenac for pain in osteoarthritis of the knee: a review.

  2006cited by this paper
• Glutamate receptors and pain.

  2006cited by this paper
• Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording

  2004cited by this paper
• Neuropathic pain symptoms relative to overall pain rating.

  2004cited by this paper
• Is the second phase of the formalin test useful to predict activity in chronic constriction injury models? A pharmacological comparison in different species.

  2003cited by this paper
• Plasticity in Action of Intrathecal Clonidine to Mechanical but Not Thermal Nociception after Peripheral Nerve Injury

  2003cited by this paper
• Descending control of pain.

  2002cited by this paper
• Pharmacological characterisation of the spared nerve injury model of neuropathic pain

  2002cited by this paper
• Alpha2 receptors and agonists in pain management

  2001cited by this paper
• Gabapentin inhibits the substance P‐facilitated K+‐evoked release of [3H]glutamate from rat caudal trigeminal nucleus slices

  2001cited by this paper
• Glutamate Receptors and Nociception

  2001cited by this paper
• Chronic Neuropathic Pain: Mechanisms and Treatment

  2000cited by this paper
• Neuronal plasticity: increasing the gain in pain.

  2000cited by this paper
• Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?

  1999cited by this paper
• Epidural clonidine analgesia for intractable cancer pain

  1995cited by this paper
• Descending control of pain.

  1995cited by this paper
• Quantitative assessment of tactile allodynia in the rat paw.

  1994cited by this paper
• An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

  1992cited by this paper
• A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

  1990cited by this paper
• A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

  1988cited by this paper
• A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

  1987cited by this paper
• Tolerance development to the biphasic effects of morphine on locomotor activity and brain acetylcholine in the rat.

  1978influential reference

• Enhanced pain relief with guanfacine as an adjuvant for trigeminal nerve blocks: insights from a PheWAS-guided randomized controlled study

  2025cites this paper
• Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic neuropathic pain

  2025cites this paper
• A novel Nav1.7, Nav1.8, and Nav1.9 blocker, ANP-230, has broad analgesic efficacy in preclinical pain models with favorable safety margins.

  2025cites this paper
• Strategies for Measuring Non-Evoked Pain in Preclinical Models of Neuropathic Pain: Systematic Review.

  2024cites this paper
• Prospects of Electrocorticography in Neuropharmacological Studies in Small Laboratory Animals

  2024cites this paper
• Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats

  2024cites this paper
• Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features

  2024cites this paper
• Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats

  2023cites this paper
• Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats

  2023cites this paper
• RALY participates in nerve trauma‐induced nociceptive hypersensitivity through triggering Eif4g2 gene expression in primary sensory neurons

  2023cites this paper
• Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators

  2022cites this paper
• The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action

  2022cites this paper
• Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain.

  2021cites this paper
• Astragalin Alleviates Neuropathic Pain by Suppressing P2X4-Mediated Signaling in the Dorsal Root Ganglia of Rats

  2021cites this paper
• Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System

  2021cites this paper
• Salting-out assisted liquid-liquid extraction method optimized by design of experiments for the simultaneous HPLC analysis of perampanel and stiripentol in mouse matrices.

  2020cites this paper
• Intrathecally administered perampanel alleviates neuropathic and inflammatory pain in rats.

  2020cites this paper
• ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain.

  2020cites this paper
• The Novel Direct Modulatory Effects of Perampanel, an Antagonist of AMPA Receptors, on Voltage-Gated Sodium and M-type Potassium Currents

  2019cites this paper
• Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats.

  2019cites this paper
• Anti-IL-6 Receptor Antibody Inhibits Spontaneous Pain at the Pre-onset of Experimental Autoimmune Encephalomyelitis in Mice

  2019cites this paper
• Effects of intraplantar administration of Complete Freund’s Adjuvant (CFA) on rotarod performance in mice

  2019cites this paper
• Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex

  2019cites this paper
• Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses.

  2019cites this paper
• A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia.

  2019cites this paper
• Adipose-derived Mesenchymal Stem Cells Improve Both Spontaneous Pain and Allodynia in a Rat Neuropathic Pain Model

  2018cites this paper
• Sustained analgesic effect of clonidine co-polymer depot in a porcine incisional pain model

  2018cites this paper
• Nerve Decompression Improves Spinal Synaptic Plasticity of Opioid Receptors for Pain Relief

  2018cites this paper
• Analgesic effects of ASP3662, a novel 11β‐hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain

  2018cites this paper
• Adipose-derived Mesenchymal Stem Cells Improve Spontaneous Pain in a Rat Model of Neuropathic Pain

  2018cites this paper
• Endogenous Opiates and Behavior: 2016.

  2018cites this paper
• Nitroglycerin challenge induces lateralized headache in nasociliarynerve-ligated rats: implications for chronic migraine.

  2017cites this paper
• Facial pain and anxiety-like behavior are reduced by pregabalin in a model of facial carcinoma in rats.

  2017cites this paper
• Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain

  2017cites this paper
• In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor

  2017cites this paper
• Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents

  2017cites this paper
• The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.

  2017cites this paper
• Electroencephalographic signatures of pain and analgesia in rats

  2016cites this paper