Transforming growth factor beta signaling through Smad1 in human breast cancer cells.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cancer Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9788633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular and cell biology of TGF-beta.

  1998cited by this paper
• Induction of Smad6 mRNA by bone morphogenetic proteins.

  1998cited by this paper
• Determinants of specificity in TGF-beta signal transduction.

  1998cited by this paper
• SMADs: mediators and regulators of TGF-beta signaling.

  1998cited by this paper
• Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

  1998cited by this paper
• The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors

  1998cited by this paper
• Blockade of TGFβ3 up-regulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells

  1998cited by this paper
• TGF-beta receptors and signalling mechanisms.

  1998cited by this paper
• Smads are the central component in transforming growth factor-beta signaling.

  1998cited by this paper
• The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

  1997cited by this paper
• Transforming growth factor-beta signaling in epithelial cells.

  1997cited by this paper
• Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

  1997cited by this paper
• TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

  1997cited by this paper
• TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

  1997cited by this paper
• Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

  1997cited by this paper
• TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells.

  1997cited by this paper
• Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

  1997cited by this paper
• Smad6 inhibits signalling by the TGF-beta superfamily.

  1997cited by this paper
• The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.

  1997cited by this paper
• Transforming growth factor (TGF-beta)-specific signaling by chimeric TGF-beta type II receptor with intracellular domain of activin type IIB receptor.

  1997cited by this paper
• Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

  1997cited by this paper
• The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

  1997cited by this paper
• Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.

  1997cited by this paper
• Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

  1997cited by this paper
• Activation of signalling by the activin receptor complex

  1996cited by this paper
• Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human bsp-1*

  1996cited by this paper
• MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

  1996cited by this paper
• Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.

  1996cited by this paper
• Altered Transforming Growth Factor β Signaling in Epithelial Cells when Ras Activation Is Blocked*

  1996cited by this paper
• Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

  1996cited by this paper
• Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors*

  1996cited by this paper
• Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.

  1996cited by this paper
• Intracellular signalling: the mad way to do it.

  1996cited by this paper
• Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

  1996cited by this paper
• Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects

  1995cited by this paper
• Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells (*)

  1995cited by this paper
• Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

  1994cited by this paper
• A transforming growth factor beta type I receptor that signals to activate gene expression.

  1994cited by this paper
• Mechanism of activation of the TGF-beta receptor.

  1994cited by this paper
• Homomeric interactions between type II transforming growth factor-beta receptors.

  1994cited by this paper
• Role of receptor complexes in resistance or sensitivity to growth inhibition by TGFβ in intestinal epithelial cell clones

  1993cited by this paper
• Activation of p21ras by transforming growth factor beta in epithelial cells.

  1992cited by this paper
• TGF beta signals through a heteromeric protein kinase receptor complex.

  1992cited by this paper
• High-efficiency transformation of mammalian cells by plasmid DNA.

  1987cited by this paper

• TGFβ-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblasts

  2025cites this paper
• Proteomic and phosphoproteomic analyses of Jurkat T-cell treated with 2'3' cGAMP reveals various signaling axes impacted by cyclic dinucleotides.

  2023cites this paper
• Separating friend from foe; inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.

  2023cites this paper
• SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4

  2022cites this paper
• The Interaction Between SMAD1 and YAP1 Is Correlated with Increased Resistance of Gastric Cancer Cells to Cisplatin

  2022cites this paper
• SMAD1 as a biomarker and potential therapeutic target in drug-resistant multiple myeloma

  2021cites this paper
• TGF-β Signaling

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• Mechanism of CK2.3, a Novel Mimetic Peptide of Bone Morphogenetic Protein Receptor Type IA, Mediated Osteogenesis

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• Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling.

  2019cites this paper
• Bone morphogenetic protein signaling in breast cancer progression

  2019cites this paper
• TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

  2018cites this paper
• Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection

  2018cites this paper
• Signaling by TGF-betas in tubule cultures of adult rat testis.

  2017cites this paper
• TGF-β signalling in tumour associated macrophages.

  2017cites this paper
• Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.

  2017cites this paper
• Signaling Receptors for TGF-β Family Members.

  2016cites this paper
• TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

  2016cites this paper
• The Regulation of spinal neurogenesis by PTPγ

  2015cites this paper
• EgoNet: identification of human disease ego-network modules

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• Mir-29 Repression in Bladder Outlet Obstruction Contributes to Matrix Remodeling and Altered Stiffness

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• Latent transforming growth factor binding protein 4 (LTBP4) is downregulated in mouse and human DCIS and mammary carcinomas

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• Oncostatin M is a novel inhibitor of TGF-β1-induced matricellular protein expression.

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• The Role of Activin in Mammary Gland Development and Oncogenesis

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• TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch

  2009cites this paper
• TGF b-stimulated Smad 1 / 5 phosphorylation requires the ALK 5 L 45 loop and mediates the pro-migratory TGF b switch

  2009cites this paper
• Bone morphogenetic protein‐4 induced Rat hepatic progenitor cell (WB‐F344 cell) differentiation toward hepatocyte lineage

  2009cites this paper
• Bone morphogenetic protein-7 induces telomerase inhibition, telomere shortening, breast cancer cell senescence, and death via Smad3.

  2009cites this paper
• Ethanol Affects Transforming Growth Factor β1-Initiated Signals: Cross-Talking Pathways in the Developing Rat Cerebral Wall

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• TGF-beta1-induced cardiac myofibroblasts are nonproliferating functional cells carrying DNA damages.

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• Humoral Bone Morphogenetic Protein 2 Is Sufficient for Inducing Breast Cancer Microcalcification

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• Transforming Growth Factor β-Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

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• Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype.

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• Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.

  2007cites this paper
• Increased Smad1 expression and transcriptional activity enhances trans‐differentiation of hepatic stellate cells

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• Induction of Smad1 by MT1‐MMP contributes to tumor growth

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• Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells.

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• Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation.

  2005cites this paper
• Lateral signaling enhances TGF-beta response complexity.

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• Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents.

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• Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation.

  2003cites this paper
• The Smad pathway in transforming growth factor-β signaling

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• Reversal of tumor-induced immunosuppression by TGF-beta inhibitors.

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• Methanandamide increases COX‐2 expression and tumor growth in murine lung cancer

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• Transforming growth factor beta-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells.

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• Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells.

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• Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta.

  2002cites this paper
• Conditional knockout of the Smad1 gene

  2002cites this paper
• Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells.

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• Role of Smad1 and Smad4 proteins in the induction of p21 during bone morphogenetic protein-induced growth arrest in human breast cancer cells

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• Role of Smad 1 and Smad 4 proteins in the induction of p 21 WAF 1 , Cip 1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells

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• TGF-beta signaling in mammary gland development and tumorigenesis.

  2001cites this paper
• Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis.

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• Transforming growth factor-beta signal transduction in epithelial cells.

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• Intracellular BMP signaling regulation in vertebrates: pathway or network?

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• Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues.

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• Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.

  2000cites this paper
• TGF-beta signaling by Smad proteins.

  2000cites this paper
• Role of Ras and Mapks in TGFbeta signaling.

  2000cites this paper
• Crossing Smads.

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• Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling.

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• Smad6 Is a Smad1/5-induced Smad Inhibitor

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• Specificity, diversity, and regulation in TGF-beta superfamily signaling.

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• p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells.

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• G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.

  1999cites this paper
• TGF-beta signaling from receptors to the nucleus.

  1999cites this paper
• Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells.

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• The role for transforming growth factor-beta (TGF-beta) in human cancer.

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• Developmental tumours, early differentiation and the transforming growth factor beta superfamily.

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