ROLE OF CTLA-4 IN XENOTRANPLANTATION

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Unknown venue

• Publication date

  2009-12-31

• Fields of study

  Medicine

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases.

  2008cited by this paper
• Anti-CTLA4 monoclonal antibody Ipilimumab in the treatment of metastatic melanoma: recent findings.

  2008cited by this paper
• Cytotoxic T-Lymphocyte–Associated Antigen-4

  2007cited by this paper
• Immunotherapy and immunoescape in colorectal cancer.

  2007cited by this paper
• Cytotoxic T-Lymphocyte–Associated Antigen-4

  2007cited by this paper
• Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events.

  2007cited by this paper
• Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer.

  2007cited by this paper
• Update on anti-CTLA-4 antibodies in clinical trials

  2007cited by this paper
• Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4)

  2007cited by this paper
• T cell‐mediated xenograft rejection: Specific tolerance is probably required for long term xenograft survival

  1998cited by this paper
• Positive and negative regulation of human T cell activation mediated by the CTLA-4/CD28 ligand CD80.

  1998cited by this paper
• Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.

  1997cited by this paper
• Clinical xenotransplantation of solid organs.

  1997cited by this paper
• Some problems related to discordant xenografting.

  1997cited by this paper
• CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

  1997cited by this paper
• CD28 costimulation promotes the production of Th2 cytokines.

  1997cited by this paper
• Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

  1997cited by this paper
• CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

  1997cited by this paper
• ImmunoBiology: The Immune System in Health and Diseases

  1996cited by this paper
• CTLA-4 ligation blocks CD28-dependent T cell activation [published erratum appears in J Exp Med 1996 Jul 1;184(1):301]

  1996influential reference
• Detection of primary direct and indirect human anti‐porcine T cell responses using a porcine dendritic cell population

  1996cited by this paper
• CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism.

  1996cited by this paper
• CTLA-4: a negative regulator of autoimmune disease

  1996cited by this paper
• Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand.

  1996cited by this paper
• Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

  1996cited by this paper
• The in vivo mechanism of action of CTLA4Ig.

  1996influential reference
• Interactions of CD80 and CD86 with CD28 and CTLA4.

  1996cited by this paper
• CD28/B7 system of T cell costimulation.

  1996influential reference
• CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

  1996cited by this paper
• Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

  1995cited by this paper
• Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.

  1995cited by this paper
• CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

  1995cited by this paper
• The generation of transgenic pigs as potential organ donors for humans

  1995cited by this paper
• Co-stimulation lowers the threshold for activation of naive T cells by bacterial superantigens.

  1995cited by this paper
• Toward novel antirejection strategies: in vivo immunosuppressive properties of CTLA4Ig.

  1995cited by this paper
• Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

  1994cited by this paper
• CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity.

  1994cited by this paper
• The B7 and CD28 receptor families.

  1994cited by this paper
• CTLA-4 can function as a negative regulator of T cell activation.

  1994cited by this paper
• Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1

  1994cited by this paper
• Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2.

  1994cited by this paper
• Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion

  1993cited by this paper
• Characterization of CTLA-4 structure and expression on human T cells.

  1993cited by this paper
• Differential T cell costimulatory requirements in CD28-deficient mice.

  1993cited by this paper
• Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

  1993cited by this paper
• CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

  1993cited by this paper
• Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

  1993cited by this paper
• CTLA-4 and CD28: similar proteins, neighbouring genes.

  1992cited by this paper
• Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

  1992cited by this paper
• CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

  1992cited by this paper
• Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.

  1992cited by this paper
• CTLA-4 is a second receptor for the B cell activation antigen B7

  1991influential reference
• Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28.

  1991cited by this paper
• T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

  1990cited by this paper
• Effector mechanisms in allograft rejection.

  1987cited by this paper
• A new member of the immunoglobulin superfamily—CTLA-4

  1987cited by this paper

• SELECTIVE T CELL CO-STIMULATION MODULATORS, AN IMPROVED THERAPEUTIC APPROACH OVER CALCINEURIN INHIBITORS IN IMMUNOSUPPRESSIVE DRUG THERAPY

  2010influential citation