Fc fragment activation of T lymphocytes. I. Fc fragments trigger Lyt 1+23- T lymphocytes to release a helper T cell-replacing activity.

Fc fragments of human IgG stimulate both proliferation and polyclonal antibody formation by B lymphocytes. T lymphocytes, although not proliferating in response to Fc fragments, are triggered to produce a T cell-replacing factor, which substitutes for T cells in the Fc fragment-induced polyclonal response. The factor is produced within 24 hr after Fc stimulation. Neither Fab fragments nor whole IgG have the capacity to stimulate the release of this activity. This material is a product of Lyt 1+23-, Ia-T lymphocytes and requires Ia+ adherent accessory cells for production. The role of the accessory cell is to process the Fc fragments to biologically active 14,000-daltons subfragments, which directly trigger T cells to factor production. This material has been called (Fc)TRF to distinguish it from other T cell factors.

• Publication year

  1981

• Venue

  Journal of Immunology

• Publication date

  1981-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.4049/jimmunol.126.2.632PMID 6969757
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• The factor is produced by Lyt 1+23- Ia- T lymphocytes and depends on Ia+ adherent accessory cells, which process Fc fragments into 14,000-dalton subfragments that directly trigger T cells.

  Confidence 0.98

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• Neither Fab fragments nor whole IgG induces release of the T cell-replacing factor activity.

  Confidence 0.94

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• Fc fragments trigger T lymphocytes to release a T cell-replacing factor that can substitute for T cells in the Fc fragment-induced polyclonal response, and this activity appears within 24 hours of stimulation.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• Fc fragments of human IgG stimulate both B-cell proliferation and polyclonal antibody formation.

  Confidence 0.97

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review

• 14,000-dalton subfragments

  protein fragments

  Smaller Fc-derived fragments generated by accessory-cell processing before they stimulate T cells.

  Aliases: 14 kDa subfragments

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• b lymphocytes

  cell types

  The B-cell population measured for proliferation and antibody production in response to Fc fragments.

  Aliases: B cells

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• fab fragments

  protein fragments

  The antigen-binding fragments of IgG tested as a control fragment lacking the Fc region.

  Aliases: Fab

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• fc fragments of human igg

  protein fragments

  Proteolytic Fc portions of human immunoglobulin G used as the stimulatory material in the study.

  Aliases: Fc fragments

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• ia+ adherent accessory cells

  accessory cell types

  Adherent accessory cells bearing Ia antigens that are required to process Fc fragments before T-cell activation.

  Aliases: Ia+ accessory cells, adherent accessory cells

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• lyt 1+23- ia- t lymphocytes

  cell subsets

  A T-lymphocyte subset identified by Lyt and Ia surface markers that produces the factor after Fc stimulation.

  Aliases: Lyt 1+23- T lymphocytes, Ia- T lymphocytes

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• polyclonal antibody formation

  immune responses

  Broad antibody production by multiple B-cell clones in the Fc fragment-induced response.

  Aliases: polyclonal response, polyclonal antibody response

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• t cell-replacing factor

  cytokine activities

  A soluble helper activity released by stimulated T lymphocytes that can substitute for T cells in the Fc fragment response.

  Aliases: (Fc)TRF, helper T cell-replacing activity

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• t lymphocytes

  cell types

  The T-cell population examined for factor release after Fc fragment stimulation.

  Aliases: T cells

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review
• whole igg

  proteins

  Intact immunoglobulin G molecules tested as a control form of IgG.

  Aliases: intact IgG

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewAK (4715169a40) review

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