Pharmacological analysis of the haemodynamic effects of 5‐HT1B/D receptor agonists in the normotensive rat

No abstract is available for this paper.

• Publication year

  1998

• Venue

  British Journal of Pharmacology

• Publication date

  1998-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/sj.bjp.0701593PMID 9489607PMCID PMC1565155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat

  2005cited by this paper
• The pharmacokinetics and effects on blood pressure of multiple doses of the novel anti-migraine drug zolmitriptan (311C90) in healthy volunteers.

  2003influential reference
• How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines.

  1997cited by this paper
• Mediation of 5‐HT‐induced external carotid vasodilatation in GR 127935‐pretreated vagosympathectomized dogs by the putative 5‐HT7 receptor

  1997cited by this paper
• How Efficacious are 5-HT1B/D Receptor Ligands: an Answer from GTPγS Binding Studies with Stably Transfected C6-glial Cell Lines

  1997cited by this paper
• Receptor specificity and trigemino‐vascular inhibitory actions of a novel 5‐HT1B/1D receptor partial agonist, 311C90 (zolmitriptan)

  1997influential reference
• Role of 5‐ht7 receptors in the long‐lasting hypotensive response induced by 5‐hydroxytryptamine in the rat

  1997influential reference
• Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats; close resemblance to the cloned 5-ht7 receptor.

  1997influential reference
• Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy

  1997cited by this paper
• Interactions of GR127935, a 5-HT1B/D receptor ligand, with functional 5-HT receptors

  1997cited by this paper
• The haemodynamic effects of subcutaneous sumatriptan, a 5HT1-receptor agonist.

  1997cited by this paper
• Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist.

  1997cited by this paper
• Nitric oxide regulation of TP receptor-mediated pulmonary vasoconstriction in the anesthetized, open-chest rat.

  1996cited by this paper
• Influence of vascular tone on vasoconstrictor responses to the 5-HT 1-like receptor agonist sumatriptan in anaesthetised rabbits.

  1996cited by this paper
• Influence of the endothelium and nitric oxide on the contractile responses evoked by 5‐HT1D receptor agonists in the rabbit isolated saphenous vein

  1996cited by this paper
• Operational characteristics of the 5-HT1-like receptors mediating external carotid vasoconstriction in vagosympathectomized dogs

  1996cited by this paper
• Blockade of porcine carotid vascular responses to sumatriptan by GR127935, a selective 5‐HT1D receptor antagonist

  1996cited by this paper
• Inhibition of trigeminal neurons by intravenous administration of the serotonin (5HT)1B/D receptor agonist zolmitriptan (311C90): are brain stem sites therapeutic target in migraine ?

  1996cited by this paper
• Use of the pithed rat model to determine the relative potencies of 5-HT2A/2C receptor antagonists following acute intravenous and oral administration.

  1995cited by this paper
• Vascular 5‐HT1‐like receptors mediating vasoconstriction and vasodilatation: their characterization and distribution in the intact canine cardiovascular system

  1995cited by this paper
• A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.

  1995cited by this paper
• PLASMA-GLUCOSE AND CARDIOVASCULAR STUDIES IN THE RAT WITH WAY100635, A SELECTIVE, POTENT 5-HT1A RECEPTOR ANTAGONIST

  1994influential reference
• Peripheral and Central Trigeminovascular Activation in Cat is Blocked by the Serotonin (5HT)‐I D Receptor Agonist 311C90

  1994cited by this paper
• Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists.

  1994cited by this paper
• Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.

  1994influential reference
• Joint 1994 Wolff Award Presentation. Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (5HT)-1D receptor agonist 311C90.

  1994cited by this paper
• Effect of Subcutaneous Sumatriptan, a Selective 5HT1 Agonist, on the Systemic, Pulmonary, and Coronary Circulation

  1993cited by this paper
• 5‐HT1B receptors mediate potent contractile responses to 5‐HT in rat caudal artery

  1993cited by this paper
• Clinical and experimental effects of sumatriptan in humans.

  1993cited by this paper
• Hypotensive effects of 5-HT1A receptor activation: ventral medullary sites and mechanisms of action in the rat.

  1993cited by this paper
• Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig

  1992cited by this paper
• Autoradiographic localization of 5HT1 binding sites in autonomic areas of the rat dorsomedial medulla oblongata

  1992cited by this paper
• Evidence that the lateral tegmental field plays an important role in the central sympathoinhibitory action of 8-OH-DPAT.

  1992cited by this paper
• The effects of 8-OH-DPAT on medullary 5-HT neurons and sympathetic activity in baroreceptor-denervated animals.

  1991cited by this paper
• Studies on the site and mechanism of the sympatholytic action of 8-OH DPAT.

  1990influential reference
• Cardiovascular Effects of Serotonin Agonists and Antagonists

  1990cited by this paper
• Overview of initial clinical studies with intravenous and oral GR43175 in acute migraine

  1989cited by this paper
• GR43175, a selective agonist for the 5‐HT1‐like receptor in dog isolated saphenous vein

  1988cited by this paper
• Flesinoxan lowers blood pressure and heart rate in cats via 5-HT1A receptors.

  1988influential reference
• Effects of serotonin1 and serotonin2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity.

  1987cited by this paper
• Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats.

  1987cited by this paper
• Cardiovascular Response to 8-Hydroxy-2-(di-n-Propylamino) Tetralin (8-OH-DPAT) in the Rat: Site of Action and Pharmacological Analysis

  1987influential reference

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• Pharmacology of triptans

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• Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.

  1999cites this paper
• Triptans: turning treatment in cluster headache attack

  1999cites this paper
• Present and future of 5-HT receptor agonists as antimigraine drugs.

  1999cites this paper
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  1998cites this paper