Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Chemistry

• Publication date

  2016-04-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/chem.201600338PMID 26917097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis and biological properties of multivalent iminosugars

  2015cited by this paper
• Polymeric iminosugars improve the activity of carbohydrate-processing enzymes.

  2015cited by this paper
• Massenspektrometrie zur Quantifizierung von Wechselwirkungen zwischen Proteinen – von molekularen Chaperonen zu Membranporinen

  2014cited by this paper
• Jack bean α-mannosidase: amino acid sequencing and N-glycosylation analysis of a valuable glycomics tool.

  2014cited by this paper
• Mass spectrometry quantifies protein interactions--from molecular chaperones to membrane porins.

  2014cited by this paper
• A Convergent Strategy for the Synthesis of Second‐Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

  2014cited by this paper
• From Glycopeptides to Glycopeptoids

  2014cited by this paper
• The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

  2014cited by this paper
• Multivalent inhibitors for carbohydrate-processing enzymes: beyond the "lock-and-key" concept.

  2014cited by this paper
• Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

  2014cited by this paper
• Bridging lectin binding sites by multivalent carbohydrates.

  2013cited by this paper
• Reduced steric hindrance and optimized spatial arrangement of carbohydrate ligands in imprinted monolayers for enhanced protein binding.

  2013cited by this paper
• Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

  2013cited by this paper
• Multivalent glycoconjugate syntheses and applications using aromatic scaffolds.

  2013cited by this paper
• Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster‐Based Correctors

  2013cited by this paper
• Structural effects of proline substitution and metal binding on hexameric cyclic peptoids.

  2013cited by this paper
• The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin‐Based Iminosugar Click Clusters

  2013cited by this paper
• Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands.

  2011cited by this paper
• The multivalent effect in glycosidase inhibition: probing the influence of architectural parameters with cyclodextrin-based iminosugar click clusters.

  2011cited by this paper
• Jack bean α-mannosidase (Jbα-man): tolerance to alkali, chelating and reducing agents and energetics of catalysis and inhibition.

  2011cited by this paper
• Properties and Bioactivities of Peptoids Tagged with Heterocycles

  2011cited by this paper
• Peptoid macrocycles: making the rounds with peptidomimetic oligomers.

  2010cited by this paper
• Multivalent lectin-carbohydrate interactions energetics and mechanisms of binding.

  2010cited by this paper
• Sedimentation patterns of rapidly reversible protein interactions.

  2010cited by this paper
• Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

  2010cited by this paper
• An efficient modular approach for the assembly of s-linked glycopeptoids.

  2009cited by this paper
• Maximising multivalency effects in protein-carbohydrate interactions.

  2009cited by this paper
• Analytical ultracentrifugation: sedimentation velocity and sedimentation equilibrium.

  2008cited by this paper
• Cyclic peptoids.

  2007cited by this paper
• Synthetic Multivalent Molecules

  2004cited by this paper
• Calculating sedimentation coefficient distributions by direct modeling of sedimentation velocity concentration profiles.

  2004cited by this paper
• Influencing receptor-ligand binding mechanisms with multivalent ligand architecture.

  2002cited by this paper
• Modern analytical ultracentrifugation in protein science: A tutorial review

  2002cited by this paper
• Bivalent inhibition of human β-tryptase

  2001cited by this paper
• Bivalent inhibition of human beta-tryptase.

  2001cited by this paper
• Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

  2000cited by this paper
• Synthesis and biological evaluation of α-D-mannopyranoside-containing dendrimers

  1998cited by this paper
• Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren

  1998cited by this paper
• Identification of the Active Site Nucleophile in Jack Bean α-Mannosidase Using 5-Fluoro-β-l-Gulosyl Fluoride*

  1998cited by this paper
• Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.

  1998cited by this paper
• Varying the Size of Multivalent Ligands: The Dependence of Concanavalin A Binding on Neoglycopolymer Length

  1997cited by this paper
• Macromolecular recognition: effect of multivalency in the inhibition of binding of yeast mannan to concanavalin A and pea lectins by mannosylated dendrimers.

  1996cited by this paper
• Carbohydrate-Protein Interactions: Basis of Glycobiology

  1995cited by this paper
• Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

  1992cited by this paper
• Characterization of jack-bean alpha-D-mannosidase as a zinc metalloenzyme.

  1975cited by this paper

• A Bis-Glycosylamine Strategy for the Synthesis of Dimeric Iminosugars Based on a DAB-1 Scaffold

  2025cites this paper
• Deconstructing Best-in-Class Neoglycoclusters as a Tool for Dissecting Key Multivalent Processes in Glycosidase Inhibition.

  2024cites this paper
• Dissecting Key Multivalent Processes in Glycosidase Inhibition: Insights from Thermodynamic Modelling and Atomistic Simulations

  2023cites this paper
• From Sweet Molecular Giants to Square Sugars and Vice Versa

  2023cites this paper
• Phosphorus Dendrimers for Metal-Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease.

  2023cites this paper
• Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

  2022cites this paper
• Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents

  2022cites this paper
• Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance

  2022cites this paper
• Hybrid Multivalent Jack Bean α-Mannosidase Inhibitors: The First Example of Gold Nanoparticles Decorated with Deoxynojirimycin Inhitopes

  2021cites this paper
• Recent advances in multivalent carbon nanoform-based glycoconjugates.

  2021cites this paper
• An overview of therapeutic potential of N-alkylated 1-deoxynojirimycin congeners.

  2021cites this paper
• Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide-deoxynojirimycin Conjugates.

  2021cites this paper
• Multivalent Resorcinarene Clusters Decorated with DAB-1 Inhitopes: Targeting Golgi α-Mannosidase from Drosophila Melanogaster

  2021cites this paper
• Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

  2021cites this paper
• Carbohydrate supramolecular chemistry: beyond the multivalent effect.

  2020cites this paper
• Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease.

  2020cites this paper
• Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding

  2020cites this paper
• Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters

  2020influential citation
• Multivalent Effect in Glycosidase Inhibition: The End of the Beginning.

  2019cites this paper
• Tight-binding inhibition of jack bean α-mannosidase by glycoimidazole clusters.

  2019cites this paper
• Monitoring glycosidase activity for clustered sugar substrates, a study on β-glucuronidase

  2019cites this paper
• Functionalized Helical β-Peptoids.

  2019cites this paper
• Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors.

  2019cites this paper
• Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative.

  2019cites this paper
• Pharmacological Chaperones for the Treatment of α-Mannosidosis.

  2019cites this paper
• Cluster glycosides and heteroglycoclusters presented in alternative arrangements

  2018cites this paper
• Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

  2018cites this paper
• Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors.

  2018cites this paper
• Structural Basis of Outstanding Multivalent Effects in Jack Bean α-Mannosidase Inhibition.

  2018cites this paper
• Stereocontrolled synthesis of polyhydroxylated bicyclic azetidines as a new class of iminosugars.

  2018cites this paper
• Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids.

  2018cites this paper
• Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors.

  2018cites this paper
• Recent Advances in the Synthesis of Peptoid Macrocycles

  2018cites this paper
• Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers.

  2017cites this paper
• Multivalency as an action principle in multimodal lectin recognition and glycosidase inhibition: a paradigm shift driven by carbon-based glyconanomaterials.

  2017cites this paper
• Fullerene hexa-adduct scaffolding for the construction of giant molecules.

  2017cites this paper
• Synthesis, crystallization, X-ray structural characterization and solid-state assembly of a cyclic hexapeptoid with propargyl and methoxyethyl side chains.

  2017cites this paper
• Multivalency To Inhibit and Discriminate Hexosaminidases.

  2017cites this paper
• Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases.

  2017cites this paper
• The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study.

  2017cites this paper
• Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases

  2016cites this paper
• Ring size effect on the solid state assembly of propargyl substituted hexa- and octacyclic peptoids

  2016cites this paper
• Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes

  2016cites this paper
• Mechanistic Insight into Heptosyltransferase Inhibition by using Kdo Multivalent Glycoclusters.

  2016cites this paper
• Investigation of original multivalent iminosugars as pharmacological chaperones for the treatment of Gaucher disease.

  2016cites this paper
• Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.

  2016cites this paper