Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2015-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/jcbfm.2014.167PMID 25248836PMCID PMC4294393
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• FibrilTool, an ImageJ plug-in to quantify fibrillar structures in raw microscopy images

  2014cited by this paper
• Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

  2013cited by this paper
• Effects of Poly (ADP-ribose) Polymerase Inhibitor 3-Aminobenzamide on Blood–Brain Barrier and Dopaminergic Neurons of Rats with Lipopolysaccharide-Induced Parkinson’s Disease

  2013cited by this paper
• Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo

  2013cited by this paper
• Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier.

  2013cited by this paper
• Activation of Cannabinoid Receptor 2 Attenuates Leukocyte–Endothelial Cell Interactions and Blood–Brain Barrier Dysfunction under Inflammatory Conditions

  2012cited by this paper
• TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells.

  2012cited by this paper
• Lipopolysaccharide activates ERK-PARP-1-RelA pathway and promotes nuclear factor-κB transcription in murine macrophages.

  2012cited by this paper
• Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.

  2012cited by this paper
• PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity

  2011cited by this paper
• Study of the actin cytoskeleton in live endothelial cells expressing GFP-actin.

  2011cited by this paper
• Quantitative analysis of intravenously administered contrast media reveals changes in vascular barrier functions in a murine colitis model

  2011cited by this paper
• Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.

  2010cited by this paper
• Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood–Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis

  2010cited by this paper
• Effect of Acute Poly(ADP-Ribose) Polymerase Inhibition by 3-AB on Blood–Brain Barrier Permeability and Edema Formation after Focal Traumatic Brain Injury in Rats

  2010cited by this paper
• Role of GTPases in control of microvascular permeability.

  2010cited by this paper
• PARP inhibition: PARP1 and beyond

  2010cited by this paper
• The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.

  2010cited by this paper
• Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

  2009cited by this paper
• Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

  2009cited by this paper
• Small GTPases in mechanosensitive regulation of endothelial barrier.

  2009cited by this paper
• Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage.

  2008cited by this paper
• Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.

  2008cited by this paper
• Inhibition of glycogen synthase kinase-3.

  2008cited by this paper
• Contribution of Poly(ADP-Ribose) Polymerase to Postischemic Blood—Brain Barrier Damage in Rats

  2007cited by this paper
• Molecular mechanisms that control leukocyte extravasation through endothelial cell contacts.

  2007cited by this paper
• Anti‐inflammatory effects of PJ34, a poly(ADP‐ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice

  2006cited by this paper
• Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

  2006cited by this paper
• Unraveling signalling cascades for the Snail family of transcription factors.

  2005cited by this paper
• Rho and vascular disease.

  2005cited by this paper
• Gallotannin Inhibits the Expression of Chemokines and Inflammatory Cytokines in A549 Cells

  2005cited by this paper
• Ischemic Nitric Oxide and Poly (ADP-Ribose) Polymerase-1 in Cerebral Ischemia: Male Toxicity, Female Protection

  2005cited by this paper
• Occludin: structure, function and regulation.

  2005cited by this paper
• Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery.

  2004cited by this paper
• Aberrant Expression of the Transcription Factors Snail and Slug Alters the Response to Genotoxic Stress

  2004cited by this paper
• RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin.

  2004cited by this paper
• Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.

  2003cited by this paper
• PARP goes transcription.

  2003cited by this paper
• Meningitis-Associated Central Nervous System Complications are Mediated by the Activation of Poly(ADP-ribose) Polymerase

  2002cited by this paper
• Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia

  2002cited by this paper
• Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin.

  2001cited by this paper

• Interaction of brain endothelial cells with T cells: implications for progression and therapeutic strategies of multiple sclerosis.

  2026cites this paper
• Tuina Mitigates Blood–Brain Barrier Disruption in Hypoxic–Ischemic Encephalopathy Rats by Inhibiting PARthanatos in Endothelial Cells

  2025cites this paper
• "Yin-Yang" of PARP1 in genotoxic and inflammatory response.

  2025cites this paper
• ADP-ribosylation, a multifaceted modification: functions and mechanisms in aging and aging-related diseases.

  2024cites this paper
• Amyloid Beta-Mediated Neurovascular Toxicity in Alzheimer's Disease.

  2024cites this paper
• Glitches in the brain: the dangerous relationship between radiotherapy and brain fog

  2024cites this paper
• Emergence of cyclic hypoxia and the impact of PARP inhibitors on tumor progression

  2024cites this paper
• Activation of PARP in secondary brain injury following intracerebral haemorrhage

  2024cites this paper
• Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future.

  2023cites this paper
• Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior.

  2023cites this paper
• Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics

  2023cites this paper
• Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing

  2023cites this paper
• Poly (ADP-Ribose) Polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities.

  2023cites this paper
• Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain

  2023cites this paper
• Melatonin Is Neuroprotective in Escherichia coli Meningitis Depending on Intestinal Microbiota

  2022cites this paper
• Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases

  2022cites this paper
• Role of NAD+ and FAD in Ischemic Stroke Pathophysiology: An Epigenetic Nexus and Expanding Therapeutic Repertoire

  2022cites this paper
• Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol

  2022cites this paper
• Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors?

  2022cites this paper
• Brain Immunoinformatics: A Symmetrical Link between Informatics, Wet Lab and the Clinic

  2021cites this paper
• Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting

  2021cites this paper
• The role of PARP1 in neurodegenerative diseases and aging

  2021cites this paper
• First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers

  2020cites this paper
• miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model

  2020cites this paper
• Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes

  2020cites this paper
• Effect of 3-Aminobenzamide on the Ultrastructure of Astrocytes and Microvessels After Focal Cerebral Ischemia in Rats

  2020cites this paper
• Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

  2020cites this paper
• Effects of Drugs of Abuse on the Blood-Brain Barrier: A Brief Overview

  2020cites this paper
• Possible Therapeutic Potential of Flavonoids and Phenolic Acids from Honey in Age-Related Neurodegenerative Diseases Via Targeting NAD+ Degradation

  2020cites this paper
• Author Correction: Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

  2020cites this paper
• Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide

  2019cites this paper
• Synthetic cathinone MDPV enhances reward function through purinergic P2X7 receptor-dependent pathway and increases P2X7 gene expression in nucleus accumbens.

  2019cites this paper
• Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)

  2019cites this paper
• Poster Viewing Sessions PB01-B01 to PB03-V09

  2019cites this paper
• Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity

  2019cites this paper
• The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

  2019cites this paper
• Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation

  2018cites this paper
• Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

  2018cites this paper
• Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases

  2018cites this paper
• Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades.

  2018cites this paper
• Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice

  2018cites this paper
• Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

  2018cites this paper
• Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?

  2018cites this paper
• Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke

  2018cites this paper
• Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

  2018cites this paper
• Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures

  2017cites this paper
• Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats

  2017cites this paper
• NAD replenishment with nicotinamide mononucleotide protects blood–brain barrier integrity and attenuates delayed tissue plasminogen activator‐induced haemorrhagic transformation after cerebral ischaemia

  2017cites this paper
• Alterations in nitric oxide homeostasis during traumatic brain injury.

  2017cites this paper
• Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats

  2017cites this paper
• Therapeutic Targeting of Poly(ADP‐Ribose) Polymerase‐1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities

  2017cites this paper
• Poly(ADP‐ribose) polymerase‐1 regulates microglia mediated decrease of endothelial tight junction integrity

  2017cites this paper
• Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury

  2016cites this paper
• PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

  2016cites this paper
• Microparticle-Induced Activation of the Vascular Endothelium Requires Caveolin-1/Caveolae

  2016cites this paper
• Structural Alterations to the Endothelial Tight Junction Complex During Stroke

  2016cites this paper
• Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress

  2016cites this paper
• Dysfunction of brain pericytes in chronic neuroinflammation

  2016cites this paper
• Neuroprotective Effects of Poly(ADP-ribose)polymerase Inhibitor Olaparib in Transient Cerebral Ischemia

  2016cites this paper
• HIV-1 Induced CNS Dysfunction: Current Overview and Research Priorities.

  2016cites this paper
• The Blood-Brain Barrier in Health and Disease

  2016cites this paper
• Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium

  2015cites this paper
• Craniula: A cranial window technique for prolonged imaging of brain surface vasculature with simultaneous adjacent intracerebral injection

  2015cites this paper
• Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations

  2015cites this paper
• PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.

  2015cites this paper
• The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity

  2015cites this paper
• miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

  2015cites this paper