Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Laboratory and Clinical Medicine

• Publication date

  2004-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.LAB.2003.12.012PMID 15085079
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of Combined Cyclooxygenase-2 and Matrix Metalloproteinase Inhibition on Human Sarcoma Xenografts

  2003cited by this paper
• Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction

  2003cited by this paper
• Matrix metalloproteinases in cancer.

  2002cited by this paper
• Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets

  2002cited by this paper
• Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.

  2002cited by this paper
• Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.

  2002cited by this paper
• Sulindac Enhances Tumor Necrosis Factor-α-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-κB

  2002cited by this paper
• Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells.

  2002cited by this paper
• Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.

  2002cited by this paper
• Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non‐antimicrobial tetracycline analog (COL‐3) in a metastatic prostate cancer model

  2002cited by this paper
• Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas

  2002cited by this paper
• Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion*

  2002cited by this paper
• Global cancer statistics in the year 2000.

  2001cited by this paper
• Inhibition of tumor cell invasiveness by chemically modified tetracyclines.

  2001cited by this paper
• Expression of cyclooxygenase‐2 promotes the release of matrix metalloproteinase‐2 and ‐9 in fetal rat hepatocytes

  2001cited by this paper
• Cyclooxygenase-2: a novel target for cancer chemotherapy?

  2001cited by this paper
• Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac.

  2001cited by this paper
• Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase‐2 (COX‐2) expression and inhibited by a COX‐2–selective inhibitor, etodolac

  2001cited by this paper
• Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases.

  2001cited by this paper
• Matrix metalloproteinase inhibitors: current developments and future perspectives.

  2001cited by this paper
• Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

  2001cited by this paper
• Aspirin inhibits matrix metalloproteinase-2 activity, increases E-cadherin production, and inhibits in vitro invasion of tumor cells.

  2001cited by this paper
• Sulindac Inhibits Growth of Rat Colon Carcinoma by Inducing Apoptosis

  2000cited by this paper
• Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

  2000cited by this paper
• Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines.

  2000cited by this paper
• Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.

  2000cited by this paper
• Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients.

  2000cited by this paper
• Down‐regulation of trypsinogen‐2 expression by chemically modified tetracyclines: Association with reduced cancer cell migration

  2000cited by this paper
• Prognostic significance of matrix metalloproteinase expression in colorectal carcinomas.

  2000cited by this paper
• Combinations for cancer prevention

  2000cited by this paper
• Direct action by doxycycline against canine osteosarcoma cell proliferation and collagenase (MMP-1) activity in vitro.

  1999cited by this paper
• Activation of matrix metalloproteinase‐2 in human breast cancer cells overexpressing cyclooxygenase‐1 or ‐2

  1999cited by this paper
• Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis

  1998cited by this paper
• Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas.

  1998cited by this paper
• Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential.

  1997cited by this paper
• Aspirin use and potential mechanisms for colorectal cancer prevention.

  1997cited by this paper
• Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma.

  1996cited by this paper
• Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells.

  1995cited by this paper
• Tumor invasion and metastasis: an imbalance of positive and negative regulation.

  1991cited by this paper
• Cancer invasion and metastasis: positive and negative regulatory elements.

  1991cited by this paper
• Inhibition of mitochondrial protein synthesis leads to proliferation arrest in the G1-phase of the cell cycle.

  1986cited by this paper
• The mitochondrial genetic system as a target for chemotherapy: tetracyclines as cytostatics.

  1984cited by this paper

• Highly boosting photodynamic therapy efficacy against hypoxic tumors via antibiotic-mediated vascular normalization in a photosensitizer co-loaded MOF nanoplatform

  2026cites this paper
• Doxycycline Restores Gemcitabine Sensitivity in Preclinical Models of Multidrug-Resistant Intrahepatic Cholangiocarcinoma

  2025cites this paper
• Steroidal Alkaloids from Sarcococca saligna (Buxaceae): In Vitro and In Silico Evaluation of Their Cytotoxic Potential

  2025cites this paper
• Doxycycline and carbonated Hydroxyapatite: A synergistic approach to target cancer cells - An in vitro evaluation of the drug loaded nanoparticles and their incorporation into PLA/PEG fibres.

  2025cites this paper
• Repurposing antibiotics: A dual-action approach against bacteria-induced cancer

  2025cites this paper
• Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example

  2024cites this paper
• Knockdown Proteomics Reveals USP7 as a Regulator of Cell-Cell Adhesion in Colorectal Cancer via AJUBA

  2024cites this paper
• Systematic review on the role of the gut microbiota in tumors and their treatment

  2024cites this paper
• Current trends and future prospects of drug repositioning in gastrointestinal oncology

  2024cites this paper
• Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

  2023cites this paper
• Drug Repurposing Analysis for Colorectal Cancer through Network Medicine Framework: Novel Candidate Drugs and Small Molecules

  2023cites this paper
• Repurposing sarecycline for osteoinductive therapies: an in vitro and ex vivo assessment

  2023cites this paper
• Assessment of the In Vitro Cytotoxic Profile of Two Broad-Spectrum Antibiotics—Tetracycline and Ampicillin—On Pharyngeal Carcinoma Cells

  2022cites this paper
• Drug Repurposing Strategies for Non-Cancer to Cancer Therapeutics.

  2022cites this paper
• Overcoming Therapy Resistance in Colon Cancer by Drug Repurposing

  2022cites this paper
• Potent Anti-Inflammatory Effects of Tetracyclines on Human Eosinophils

  2021cites this paper
• The Impact of Long-Term Antibiotic Therapy of Cutaneous Adverse Reactions to EGFR Inhibitors in Colorectal Cancer Patients

  2021cites this paper
• Repurposing of Antimicrobial Agents for Cancer Therapy: What Do We Know?

  2021cites this paper
• STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis

  2021cites this paper
• A Brief look at antitumor effects of doxycycline in the treatment of colorectal cancer and combination therapies.

  2021cites this paper
• Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy

  2021cites this paper
• Doxycycline Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy in Mice

  2021cites this paper
• Progress of Phototherapy Applications in the Treatment of Bone Cancer

  2021cites this paper
• Exploring the cytotoxicity and anticancer effects of doxycycline and azithromycin on human glioblastoma multiforme cells

  2021cites this paper
• Therapeutic Efficacy of Antibiotics in the Treatment of Chronic Diseases

  2020cites this paper
• Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells

  2020cites this paper
• Mitochondria as target to inhibit proliferation and induce apoptosis of cancer cells: the effects of doxycycline and gemcitabine

  2020cites this paper
• [Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells].

  2020cites this paper
• Bone-targeting Prodrug Mesoporous Silica-Based Nanoreactor with Reactive Oxygen Species Burst for Enhanced Chemotherapy.

  2020cites this paper
• Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

  2020cites this paper
• Drug Repurposing in Oncotherapeutics

  2020cites this paper
• The Inhibitory Effects of Tetracycline on Mastocytosis

  2019influential citation
• The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review

  2019cites this paper
• Old wine in new bottles: Drug repurposing in oncology.

  2019cites this paper
• Bone Cysts Involving the Hip

  2019cites this paper
• Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs.

  2019cites this paper
• Monitoring Aggregate Clearance and Formation in Cell-Based Assays.

  2018cites this paper
• Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells

  2018cites this paper
• Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes

  2018cites this paper
• Profilin-1 deficiency leads to SMAD3 upregulation and impaired 3D outgrowth of breast cancer cells

  2018cites this paper
• In vitro anti-cancer activity of Doxycycline on some human cancer cell lines

  2018cites this paper
• Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3

  2018cites this paper
• Drug repurposing in cancer.

  2017cites this paper
• Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum.

  2016cites this paper
• Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach

  2016influential citation
• Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner.

  2016cites this paper
• Reproducibility of parameter learning with missing observations in naive Wnt Bayesian network trained on colorectal cancer samples and doxycycline-treated cell lines.

  2015cites this paper
• Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

  2015cites this paper
• DNA damage, lysosomal degradation and Bcl-xL deamidation in doxycycline- and minocycline-induced cell death in the K562 leukemic cell line.

  2015cites this paper
• In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

  2015cites this paper
• Cytotoxic Effects of Tetracycline Analogues (Doxycycline, Minocycline and COL-3) in Acute Myeloid Leukemia HL-60 Cells

  2014cites this paper
• Nanoparticle and liposome formulations of doxycycline: transport properties through Caco-2 cell line and effects on matrix metalloproteinase secretion.

  2013cites this paper
• Doxycycline Prevents Intimal Hyperplasia In Vitro and May Improve Patency of the Internal Thoracic Artery

  2013cites this paper
• Primary cutaneous CD4+ small- to medium-sized pleomorphic T-cell lymphoma: temporary remission by oral doxycycline.

  2013cites this paper
• Inhibition of matrix metalloproteinases (MMPs) as a potential strategy to ameliorate hypertension-induced cardiovascular alterations.

  2013cites this paper
• Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy

  2013cites this paper
• Top Accessed Article: Duct Tape for the Treatment of Common Warts in Adults

  2013cites this paper
• Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing

  2012cites this paper
• Sudden Death Due to Myocardial Necrosis in Imported Calves

  2012cites this paper
• Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma.

  2012cites this paper
• Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria

  2010cites this paper
• Anti-invasion and anti-tumor growth effect of doxycycline treatment for human oral squamous-cell carcinoma--in vitro and in vivo studies.

  2010cites this paper
• Dasatinib induces complete cytogenetic response and loss of F359C in an imatinib resistant chronic myelocytic leukemia patient

  2009cites this paper
• Experimental treatment of human diffuse large B‐cell lymphoma xenografts by doxycycline alone or in combination with the anti‐CD20 chimeric monoclonal antibody rituximab

  2009cites this paper
• Doxycycline enhances the Ras‐MAPK signaling and proliferation of mouse thymic epithelial cells

  2009cites this paper
• Doxycycline causes regression of endometriotic implants: a rat model.

  2009cites this paper
• Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?

  2009influential citation
• Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells

  2008cites this paper
• A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma.

  2008cites this paper
• Doxycycline Influences Microcirculation Patterns in B16 Melanoma

  2007cites this paper
• Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature

  2007cites this paper
• RETRACTED: Doxycycline alters the expression of matrix metalloproteases in the endometrial cells exposed to ovarian steroids and pro-inflammatory cytokine.

  2007cites this paper
• Anti-Tumor Effect of Doxycycline on Glioblastoma Cells

  2007cites this paper
• Inhibitory effect of an isopropanolic extract of black cohosh on the invasiveness of MDA-mB 231 human breast cancer cells.

  2007cites this paper
• Expression of cyclo‐oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor β1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine

  2006cites this paper
• Mitochondria and calpains mediate caspase-dependent apoptosis induced by doxycycline in HeLa cells

  2006cites this paper
• Facilitation of protein 3-D structure determination using enhanced peptide amide deuterium exchange mass spectrometry (DXMS)

  2006cites this paper
• Tetracycline analogues (doxycycline and COL‐3) induce caspase‐dependent and ‐independent apoptosis in human colon cancer cells

  2006influential citation
• Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: implication in irregular uterine bleeding.

  2006cites this paper
• Selective induction of cyclooxygenase‐2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation

  2006cites this paper
• Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry

  2005cites this paper
• PLK1 as a potential drug target in cancer therapy

  2004cites this paper
• Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses.

  2004cites this paper