Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Clinical Investigation

• Publication date

  2007-12-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.1172/JCI32636PMID 18097471PMCID PMC2147668
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
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  1987cited by this paper
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  1983cited by this paper
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  1976cited by this paper
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  2009cites this paper
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  2009cites this paper
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