DNAse treatment does not improve the survival of lupus prone (NZB6NZW)F1 mice

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Lupus

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1191/096120398678920037PMID 9643311
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quantitation of IgM- and IgG-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus.

  2010cited by this paper
• Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus

  2004cited by this paper
• Antibodies to DNA.

  1998cited by this paper
• The role of antibodies to DNA in systemic lupus erythematosus— A review and introduction to an international workshop on DNA antibodies held in London, May 1996

  1997cited by this paper
• Engineering hyperactive variants of human deoxyribonuclease I by altering its functional mechanism.

  1997cited by this paper
• Contribution of CpG motifs to the immunogenicity of DNA vaccines.

  1997cited by this paper
• Are DNA antibodies actually pathogenic?

  1997cited by this paper
• Measurement of deoxyribonuclease I (DNase) in the serum and urine of systemic lupus erythematosus (SLE)‐prone NZB/NZW mice by a new radial enzyme diffusion assay

  1997cited by this paper
• Development of pathogenic anti‐DNA antibodies in patients with systemic lupus erythematosus

  1997cited by this paper
• Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens.

  1996cited by this paper
• The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice; studies with recombinant murine DNase and with dexamethasone

  1996cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood.

  1996cited by this paper
• CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

  1996cited by this paper
• Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice.

  1995cited by this paper
• Inquiry into Murine and Human Lupus

  1995cited by this paper
• Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA.

  1995cited by this paper
• Anti-DNA antibodies bind to DNase I

  1995cited by this paper
• Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

  1994cited by this paper
• Efficacy and safety of short-term administration of aerosolised recombinant human DNase I in adults with stable stage cystic fibrosis.

  1993cited by this paper
• Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus

  1993cited by this paper
• Cross‐reactions of anti‐DNA autoantibodies with cell surface proteins

  1993cited by this paper
• Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms.

  1992cited by this paper
• Current protocols in immunology

  1991cited by this paper
• Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

  1990cited by this paper
• Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice.

  1990cited by this paper
• Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease.

  1990cited by this paper
• Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney.

  1989cited by this paper
• Systemic autoimmune disease arises from polyclonal B cell activation

  1987cited by this paper
• Complement fixation by small, DNase-resistant DNA-anti-DNA immune complexes.

  1987cited by this paper
• Dubois' Lupus Erythematosus

  1987cited by this paper
• The lupus autoantigens and the pathogenesis of systemic lupus erythematosus.

  1986cited by this paper
• Suppression of murine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA.

  1984cited by this paper
• Partial purification and characterization of plasma DNA and its relation to disease activity in systemic lupus erythematosus.

  1984cited by this paper
• Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome.

  1984cited by this paper
• Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus.

  1980cited by this paper
• Purification and properties of deoxyribonuclease from human urine.

  1978cited by this paper
• Studies of tolerance to DNA in NZB/NZW F1 mice.

  1977cited by this paper
• Metabolism of exogenous single stranded DNA in normal and NZB/W mice.

  1977cited by this paper
• Studies on the nature of circulating DNA in systemic lupus erythematosus (SLE).

  1975cited by this paper
• Therapeutic studies in NZB/W mice. III. Relationship between renal status and efficacy of immunosuppressive drug therapy.

  1975cited by this paper
• Therapeutic studies in NZB/W MICE

  1975cited by this paper
• Allergic reactions, connective tissue, and disease.

  1967cited by this paper

• Therapeutic Potential of DNases in Immunothrombosis: Promising Succor or Uncertain Future?

  2024cites this paper
• DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat

  2023cites this paper
• Conversion of the Liver into a Biofactory for DNaseI Using Adeno-Associated Virus Vector Gene Transfer Reduces Neutrophil Extracellular Traps in a Model of Systemic Lupus Erythematosus

  2022cites this paper
• Low‐density granulocytes in systemic autoimmunity and autoinflammation

  2022cites this paper
• Neutrophil Extracellular Traps in the Autoimmunity Context

  2021cites this paper
• Deoxyribonucleases and Their Applications in Biomedicine

  2020cites this paper
• Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review

  2020cites this paper
• Dnase1‐deficient mice spontaneously develop a systemic lupus erythematosus‐like disease

  2019cites this paper
• Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

  2018cites this paper
• Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease

  2017cites this paper
• In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody–Mediated Venous Thrombosis

  2017cites this paper
• IN VIVO STUDIES OF CELL-FREE DNA AND DNASE IN A MURINE MODEL OF POLYMICROBIAL SEPSIS

  2016cites this paper
• At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases

  2016cites this paper
• At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

  2016cites this paper
• Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury

  2016cites this paper
• Murine and Human Lupus Nephritis: Pathogenic Mechanisms and Theoretical Strategies for Therapy.

  2015cites this paper
• Low‐Dose Irinotecan Improves Advanced Lupus Nephritis in Mice Potentially by Changing DNA Relaxation and Anti–Double‐Stranded DNA Binding

  2014cites this paper
• Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.

  2013cites this paper
• Progressive lupus nephritis: Biological consequences of renal DNaseI gene silencing

  2013cites this paper
• Chapter 17 – Animal Models of SLE

  2013cites this paper
• Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept

  2013cites this paper
• Lupus nephritis : the role of renal DNase I in the progression of the disease

  2011cites this paper
• Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis.

  2011cites this paper
• Impact of chromatin in lupus nephritis and lupus dermatitis - mechanisms of induction and progression of disease

  2011cites this paper
• Structural modification of DNA—a therapeutic option in SLE?

  2011cites this paper
• Alterations in the renal microenvironment during the development of lupus nephritis Longditudinal studies in a murine model of systemic lupus erythematosus

  2010cites this paper
• Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis

  2010cites this paper
• DNase1 exon2 analysis in Tunisian patients with rheumatoid arthritis, systemic lupus erythematosus and Sjögren syndrome and healthy subjects

  2009cites this paper
• Enhanced Selection of High Affinity DNA-Reactive B Cells Following Cyclophosphamide Treatment in Mice

  2009cites this paper
• Low-Dose Targeted Complement Inhibition Protects against Renal Disease and Other Manifestations of Autoimmune Disease in MRL/lpr Mice1

  2008cites this paper
• Mice lpr MRL/Manifestations of Autoimmune Disease in Protects against Renal Disease and Other Low-Dose Targeted Complement Inhibition

  2007cites this paper
• Systemic lupus-erythematosus: deoxyribonuclease 1 in necrotic chromatin disposal.

  2006cites this paper
• The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus

  2006influential citation
• No evidence of mutation in exon 2 of DNAse1 gene in Chinese patients with systemic lupus erythematosus.

  2004cites this paper
• Ätiopathogenese des systemischen Lupus erythematodes (SLE)

  2003cites this paper
• Dnase1l3 deficiency in lupus‐prone MRL and NZB/W F1 mice

  2003cites this paper
• Histopathology of lupus-like nephritis in Dnase1-deficient mice in comparison to NZB/W F1 mice

  2002cites this paper
• The Future of Treatment for Systemic Lupus Erythematosus

  2001cites this paper
• The future of treatment for systemic lupus erythematosus.

  2001cites this paper
• New therapies for systemic lupus erythematosus.

  2000cites this paper
• Induction of anti-DNA antibodies in preautoimmune NZBxNZW F1 mice by immunization with a DNA-DNase I complex.

  2000cites this paper
• Features of systemic lupus erythematosus in Dnase1-deficient mice

  2000cites this paper
• Biologic agents and innovative interventional approaches in the management of systemic lupus erythematosus.

  1999cites this paper