Nitro-fatty Acids Occur in Human Plasma in the Picomolar Range: a Targeted Nitro-lipidomics GC–MS/MS Study

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Lipids

• Publication date

  2009-08-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11745-009-3332-4PMID 19701657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific GC-MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC-MS/MS reports.

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• GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.

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• Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids.

  2009influential reference
• Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway.

  2009cited by this paper
• Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

  2009cited by this paper
• Nitro-fatty Acid Metabolome: Saturation, Desaturation, β-Oxidation, and Protein Adduction*

  2009influential reference
• Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives.

  2009cited by this paper
• Analytical strategies in lipidomics and applications in disease biomarker discovery.

  2009cited by this paper
• The mechanism of oleic acid nitration by *NO(2).

  2008cited by this paper
• Nitro-fatty Acid Formation and Signaling*

  2008cited by this paper
• Protein and lipid nitration: role in redox signaling and injury.

  2008cited by this paper
• DETANO and nitrated lipids increase chloride secretion across lung airway cells.

  2008cited by this paper
• A critical review and discussion of analytical methods in the L-arginine/nitric oxide area of basic and clinical research.

  2008cited by this paper
• Nitrated fatty acids: mechanisms of formation, chemical characterization, and biological properties.

  2008cited by this paper
• Synthesis, isomer characterization, and anti-inflammatory properties of nitroarachidonate.

  2007cited by this paper
• Detection of S-nitrosothiols in biological fluids: a comparison among the most widely applied methodologies.

  2007cited by this paper
• Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography.

  2007cited by this paper
• Chromatographic and mass spectrometric methods for quantitative determination of 3-nitrotyrosine in biological samples and their application to human samples.

  2007cited by this paper
• Nitrated Fatty Acids: Endogenous Anti-inflammatory Signaling Mediators*

  2006cited by this paper
• Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis.

  2006cited by this paper
• Synthesis of nitrolipids. All four possible diastereomers of nitrooleic acids: (E)- and (Z)-, 9- and 10-nitro-octadec-9-enoic acids.

  2006cited by this paper
• Recent methodological advances in the mass spectrometric analysis of free and protein-associated 3-nitrotyrosine in human plasma.

  2005cited by this paper
• Fatty Acid Transduction of Nitric Oxide Signaling

  2005cited by this paper
• Fatty Acid Transduction of Nitric Oxide Signaling

  2005cited by this paper
• Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation.

  2005cited by this paper
• Nitrated lipids: a class of cell-signaling molecules.

  2004cited by this paper
• Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation.

  2004influential reference
• Ion suppression in mass spectrometry.

  2003cited by this paper
• Vicinal nitrohydroxyeicosatrienoic acids: vasodilator lipids formed by reaction of nitrogen dioxide with arachidonic acid.

  2001cited by this paper
• Free fatty acid profiles in the non-obese diabetic (NOD) mouse: basal serum levels and effects of endocrine manipulation.

  1994cited by this paper

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  2025cites this paper
• Chemoproteomic analysis reveals RECQL4 as a mediator of nitroalkene-dependent double-strand break repair inhibition in cancer.

  2025cites this paper
• Nitro-fatty acids: promising agents for the development of new cancer therapeutics.

  2024cites this paper
• Nitro fatty acids: a comprehensive review on analytical methods and levels in health and disease.

  2024cites this paper
• Malondialdehyde-Induced Post-Translational Modification of Human Hemoglobin

  2023cites this paper
• Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard.

  2023cites this paper
• Neuroprotective actions of a fatty acid nitroalkene in Parkinson’s disease

  2023cites this paper
• Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.

  2023cites this paper
• Protective Effect of NO2-OA on Oxidative Stress, Gliosis, and Pro-Angiogenic Response in Müller Glial Cells

  2023cites this paper
• Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research.

  2022cites this paper
• Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

  2021cites this paper
• Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.

  2021cites this paper
• Nitro Fatty Acids (NO2-FAs): An Emerging Class of Bioactive Fatty Acids

  2021cites this paper
• Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

  2021cites this paper
• Regulation of arachidonic acid oxidation and metabolism by lipid electrophiles.

  2020cites this paper
• Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

  2020cites this paper
• Untargeted lipidomics reveals progression of early Alzheimer’s disease in APP/PS1 transgenic mice

  2020cites this paper
• Endogenous Biosynthesis of S-Nitrosoglutathione From Nitro-Fatty Acids in Plants

  2020cites this paper
• Mass spectrometry-based study defines the human urine nitrolipidome.

  2020cites this paper
• Electrophilic characteristics and aqueous behavior of fatty acid nitroalkenes

  2020cites this paper
• Free radical-dependent inhibition of prostaglandin endoperoxide H Synthase-2 by nitro-arachidonic acid.

  2019cites this paper
• Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth

  2019cites this paper
• A FABP4-PPARγ signaling axis regulates human monocyte responses to electrophilic fatty acid nitroalkenes

  2019cites this paper
• Oxidative pathways of arachidonic acid as targets for regulation of platelet activation.

  2019cites this paper
• Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology.

  2019cites this paper
• Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches

  2019cites this paper
• New Insights into the Anti-Inflammatory and Antioxidant Properties of Nitrated Phospholipids.

  2018cites this paper
• Electrophilic fatty acid nitroalkenes are systemically transported and distributed upon esterification to complex lipids[S]

  2018cites this paper
• Nitro-fatty acid formation and metabolism.

  2018cites this paper
• Anti‐inflammatory nitro‐fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells

  2018cites this paper
• Profile of Phosphatidylserine Modifications under Nitroxidative Stress Conditions Using a Liquid Chromatography-Mass Spectrometry Based Approach

  2018cites this paper
• Characterization of Nitrophospholipid-Peptide Covalent Adducts by Electrospray Tandem Mass Spectrometry: A First Screening Analysis Using Different Instrumental Platforms

  2018cites this paper
• The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling.

  2018cites this paper
• Nitrated fatty acids in cardiovascular diseases.

  2018cites this paper
• Oxidant-specific biomarkers of oxidative stress. Association with atherosclerosis and implication for antioxidant effects.

  2018cites this paper
• The chemical foundations of nitroalkene fatty acid signaling through addition reactions with thiols.

  2018cites this paper
• Development and application of a UHPLC–MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress

  2018cites this paper
• Effects of heme oxygenase-1 recombinant Lactococcus lactis on the intestinal barrier of hemorrhagic shock rats

  2017cites this paper
• Nitro-fatty acids in plant signaling: New key mediators of nitric oxide metabolism

  2017influential citation
• Nitro‐oleic acid regulates growth factor‐induced differentiation of bone marrow‐derived macrophages

  2017cites this paper
• Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans

  2017cites this paper
• Nitroarachidonic acid (NO2AA) inhibits protein disulfide isomerase (PDI) through reversible covalent adduct formation with critical cysteines.

  2017cites this paper
• In vitro nitro-fatty acid release from Cys-NO2-fatty acid adducts under nitro-oxidative conditions.

  2017cites this paper
• Recent Advances on Mass Spectrometry Analysis of Nitrated Phospholipids.

  2016cites this paper
• Repair Mechanisms in Oxidant-Driven Chronic Inflammatory Disease.

  2016cites this paper
• Nitro-linolenic acid is a nitric oxide donor.

  2016cites this paper
• Effects of heme oxygenase-1 in the intestine on the intestinal barrier function of rats with hemorrhagic shock

  2016cites this paper
• Nitro-Fatty Acids in Plant Signaling: Nitro-Linolenic Acid Induces the Molecular Chaperone Network in Arabidopsis1[OPEN]

  2015influential citation
• Formation of Nitrated Lipids and Their Biological Relevance

  2015cites this paper
• Oxidized and Nitrated Lipid Interactions with the Keap1–Nrf2 Pathway

  2015cites this paper
• Advances in sample preparation and analytical techniques for lipidomics study of clinical samples

  2015cites this paper
• Profiling and relative quantification of multiply nitrated and oxidized fatty acids

  2015cites this paper
• Nitro-fatty acids in plant signaling: nitro-linolenic acid induces the molecular 1 chaperone network in Arabidopsis 2

  2015influential citation
• Interplay between oxidant species and energy metabolism

  2015cites this paper
• Nitro-oleic acid and epoxy-oleic acid are not altered in obesity and type 2 diabetes.

  2014cites this paper
• THE ROLE OF NITRATE AND CONJUGATED LINOLEIC ACID

  2014cites this paper
• Role of reactive lipid mediators in oxidative stress-induced toxicity

  2014cites this paper
• Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.

  2014cites this paper
• GC-MS/MS and LC-MS/MS studies on unlabelled and deuterium-labelled oleic acid (C18:1) reactions with peroxynitrite (O=N-O-O⁻) in buffer and hemolysate support the pM/nM-range of nitro-oleic acids in human plasma.

  2014cites this paper
• Diet and inflammation : the role of nitrate and conjugated linoleic acid

  2014cites this paper
• Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid.

  2014cites this paper
• Nitro-oleic acid and epoxyoleic acid are not altered in obesity and type 2 diabetes: reply.

  2014cites this paper
• NITROALKENE REDUCTASE PROSTAGLANDIN REDUCTASE-1 IS A Modulation of Nitro-fatty Acid Signaling: Lipids:

  2013cites this paper
• Nitro-fatty acids: novel anti-inflammatory lipid mediators

  2013cites this paper
• Nitro-Fatty Acids: Formation, Redox Signaling, and Therapeutic Potential

  2013cites this paper
• Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine[S]

  2013cites this paper
• Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?

  2013cites this paper
• Modulation of Nitro-fatty Acid Signaling

  2013cites this paper
• Lipid oxidation and nitration products as activators of cytoprotective Nrf2 signaling in the endothelium

  2012cites this paper
• Chemistry of phospholipid oxidation.

  2012cites this paper
• Good mass spectrometry and its place in good science.

  2012cites this paper
• Free Radical Biology and Medicine

  2012cites this paper
• Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors.

  2012cites this paper
• The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice

  2012cites this paper
• Gas-Phase Fragmentation Analysis of Nitro-Fatty Acids

  2011cites this paper
• Recent advances of chromatography and mass spectrometry in lipidomics

  2011cites this paper
• Oxidized and nitrated oleic acid in biological systems: analysis by GC-MS/MS and LC-MS/MS, and biological significance.

  2011cites this paper
• PPARs and lipid ligands in inflammation and metabolism.

  2011cites this paper
• Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species.

  2010cites this paper
• Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry

  2010cites this paper
• Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions.

  2010cites this paper
• Discovery and characterization of inflammation-induced electrophilic fatty acid derivatives

  2009cites this paper