Quantitative Prediction of CYP2B6 Induction by Estradiol During Pregnancy: Potential Explanation for Increased Methadone Clearance During Pregnancy

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Drug Metabolism And Disposition

• Publication date

  2013-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/dmd.112.047118PMID 22815312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.

  2012influential reference
• Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

  2011influential reference
• Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture

  2011cited by this paper
• Regulation of CYP2C19 Expression by Estrogen Receptor α: Implications for Estrogen-Dependent Inhibition of Drug Metabolism

  2010cited by this paper
• Substrate specificity, regulation, and polymorphism of human cytochrome P450 2B6.

  2009cited by this paper
• Role of CYP2B6 in Stereoselective Human Methadone Metabolism

  2008cited by this paper
• Effects of Pregnancy on CYP3A and P‐glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study

  2008cited by this paper
• CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.

  2008influential reference
• Pharmacokinetics of Sertraline Across Pregnancy and Postpartum

  2008cited by this paper
• Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics

  2008cited by this paper
• Current Industrial Practices in Assessing CYP450 Enzyme Induction: Preclinical and Clinical

  2008cited by this paper
• Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers

  2007cited by this paper
• Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism

  2007cited by this paper
• Evaluation of 227 Drugs for In Vitro Inhibition of Cytochrome P450 2B6

  2006cited by this paper
• Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: Effect of induction by rifampin and ethnicity

  2006influential reference
• Use of Immortalized Human Hepatocytes to Predict the Magnitude of Clinical Drug-Drug Interactions Caused by CYP3A4 Induction

  2006cited by this paper
• Changes to methadone clearance during pregnancy

  2005cited by this paper
• SERTRALINE IS METABOLIZED BY MULTIPLE CYTOCHROME P450 ENZYMES, MONOAMINE OXIDASES, AND GLUCURONYL TRANSFERASES IN HUMAN: AN IN VITRO STUDY

  2005cited by this paper
• Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry.

  2005cited by this paper
• Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types: A Synopsis

  2004cited by this paper
• The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity

  2003cited by this paper
• Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.

  2003cited by this paper
• Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice.

  2002cited by this paper
• Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.

  2001cited by this paper
• Orphan Nuclear Receptors: The Exotics of Xenobiotics*

  2001cited by this paper
• Localization of estradiol‐responsive region in the phenobarbital‐responsive enhancer module of mouse Cyp2b‐10 gene

  2001cited by this paper
• Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.

  2000cited by this paper
• Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs.

  2000cited by this paper
• Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450.

  1999cited by this paper
• Carbamazepine but not valproate induces bupropion metabolism.

  1995influential reference
• Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes.

  1995influential reference
• Longitudinal assessment of changes in reproductive hormones during normal pregnancy.

  1991influential reference
• Altered methadone pharmacokinetics in methadone-maintained pregnant women.

  1985cited by this paper
• Goodman & Gilman's The Pharmacological Basis of Therapeutics

  1985cited by this paper

• Combining the novel all-human co-cultured hepatocytes system with physiologically based pharmacokinetic modeling to assess the translatability of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase induction data.

  2026cites this paper
• Mechanisms of altered hepatic drug disposition during pregnancy: small molecules

  2025cites this paper
• Comprehensive Review of CYP2B6 Transcriptional Modulators, Variants, and Their Role in Drug Interactions

  2025cites this paper
• The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

  2024cites this paper
• Applying Physiologically Based Pharmacokinetic Modeling to Interpret Carbamazepine’s Nonlinear Pharmacokinetics and Its Induction Potential on Cytochrome P450 3A4 and Cytochrome P450 2C9 Enzymes

  2024cites this paper
• A systematic review of pregnancy-related clinical intervention of drug regimens due to pharmacokinetic reasons

  2023cites this paper
• Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications

  2023cites this paper
• Liver-specific glucocorticoid action in alcoholic liver disease: study of glucocorticoid receptor knockout and knockin mice

  2023cites this paper
• CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function

  2022cites this paper
• Drug therapy in pregnant and nursing women

  2022cites this paper
• Pharmacogenetics of lethal opioid overdose: Study protocol and preliminary ndings

  2022cites this paper
• Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

  2022cites this paper
• Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine.

  2022cites this paper
• Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model

  2022cites this paper
• The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions

  2021cites this paper
• Quinney Sara (Orcid ID: 0000-0002-6554-0695) Physiologically based pharmacokinetic modeling in pregnancy: Model reproducibility and external validation

  2021cites this paper
• A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome.

  2021cites this paper
• Use of Methadone Maintenance Therapy for Opioid Use Disorder in Pregnancy.

  2021cites this paper
• Add-On Selective Estrogen Receptor Modulators for Methadone Maintenance Treatment

  2021cites this paper
• Physiologically based pharmacokinetic modelling in pregnancy: Model reproducibility and external validation

  2021cites this paper
• Sources of Interindividual Variability.

  2021cites this paper
• Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study.

  2021cites this paper
• Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites

  2021cites this paper
• Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

  2021cites this paper
• PharmVar GeneFocus: CYP2B6

  2021cites this paper
• Drugs in pregnancy: Pharmacologic and physiologic changes that affect clinical care.

  2020cites this paper
• Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome

  2020cites this paper
• Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression.

  2020cites this paper
• Pharmacokinetics and Drug‐Drug Interactions of Isoniazid and Efavirenz in Pregnant Women Living With HIV in High TB Incidence Settings: Importance of Genotyping

  2020cites this paper
• Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

  2020cites this paper
• Pharmacokinetics of HIV therapies in pregnant patients: an update

  2020cites this paper
• Endogenous Hormones and Antiretroviral Exposure in Plasma, Cervicovaginal Fluid, and Upper-Layer Packed Cells of Malawian Women Living with HIV

  2020cites this paper
• Biomarkers of Toxicity in Human Placenta

  2019cites this paper
• Perinatal Psychopharmacology

  2019cites this paper
• Maternal and Infant Pharmacokinetics of Psychotropic Medications During Pregnancy and Lactation

  2019cites this paper
• Opioid Use and Rate of Nicotine Metabolism among Pregnant Smokers.

  2019cites this paper
• Methadone serum concentrations and influencing factors: A naturalistic observational study

  2019cites this paper
• High-content Analysis of Constitutive Androstane Receptor (CAR) Translocation Identifies Mosapride Citrate as a CAR Agonist that Represses Gluconeogenesis.

  2019cites this paper
• Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies

  2019cites this paper
• Psychotropic Treatment During Pregnancy: Research Synthesis and Clinical Care Principles

  2019cites this paper
• Progress in the Study of Gender Heterogeneity in Pharmacodynamics of Antidepressants

  2019cites this paper
• The Use of Serum Methadone/Metabolite Ratios to Monitor Changing Perinatal Pharmacokinetics

  2018cites this paper
• Pregnancy- Associated Changes in Pharmacokinetics and their Clinical Implications

  2018cites this paper
• Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection

  2018cites this paper
• A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women

  2018cites this paper
• Drug Metabolism in Pregnancy

  2017cites this paper
• Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction

  2017cites this paper
• Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine.

  2017cites this paper
• Pregnancy-Associated Changes in Pharmacokinetics: A Systematic Review

  2016cites this paper
• Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation.

  2016cites this paper
• Pharmacokinetics and Pharmacodynamics of Drugs Commonly Used in Pregnancy and Parturition

  2016cites this paper
• Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy

  2016cites this paper
• Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo

  2015cites this paper
• Hormonal Regulation of Liver Cytochrome P450 Enzymes

  2015cites this paper
• Utilizing Biomarkers to Assess Prevalence and Trends of Substance Use During Pregnancy in Canada

  2015influential citation
• Pharmacogenetics of antiretroviral drugs used for prevention of mother-to-child transmission of HIV during pregnancy and lactation

  2015cites this paper
• Clinical pharmacology of methadone in neonates and in their mothers. A review

  2015influential citation
• Genetic and cognitive aspects on recovery after propofol anaesthesia

  2015cites this paper
• The Effect of Methadone Dose Regimen on Neonatal Abstinence Syndrome

  2015influential citation
• the books NEOFAX : a Manual Used in the Neonatal Care by Young and Mangum 4 and the Neonatal Formulary

  2015influential citation
• Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research

  2015cites this paper
• Metabolism and Disposition of Bupropion in Pregnant Baboons (Papio cynocephalus)

  2014cites this paper
• Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.

  2014cites this paper
• en addictovigilance de l'exposition aux substances psychoactives pendant la grossesse

  2014cites this paper
• Médicaments de substitution aux opiacés, substances psychoactives et grossesse : approche pharmaco-épidémiologique à partir des outils employés en addictovigilance de l'exposition aux substances psychoactives pendant la grossesse

  2014cites this paper
• Characterization of CYP 2 B 6 in a CYP 2 B 6-Humanized Mouse Model : Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo s

  2014cites this paper
• The modulating effects of endogenous substances on drug metabolising enzymes and implications for inter-individual variability and quantitative prediction.

  2014cites this paper
• Microsoft Word-68364578-file00

  2014influential citation
• Metabolism and Disposition of Bupropion in Pregnant Baboons ( Papio cynocephalus )

  2014cites this paper
• Sex Differences in the Pharmacokinetics of Antidepressants: Influence of Female Sex Hormones and Oral Contraceptives

  2014cites this paper
• Drug Metabolism and Transport During Pregnancy: How Does Drug Disposition Change during Pregnancy and What Are the Mechanisms that Cause Such Changes?

  2013cites this paper
• Lessons learned from a comparison of evidence‐based research in pregnant opioid‐dependent women

  2013cites this paper
• Pregnancy and pharmacogenomics in the context of drug metabolism and response.

  2013cites this paper
• A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women

  2013cites this paper
• Rates of Fetal Polydrug Exposures in Methadone-Maintained Pregnancies from a High-Risk Population

  2013cites this paper
• Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice*

  2013cites this paper