Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Hepatology

• Publication date

  2013-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jhep.2013.01.020PMID 23353867PMCID PMC3631429
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21

  2013cited by this paper
• Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease.

  2013cited by this paper
• p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

  2012cited by this paper
• Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

  2012cited by this paper
• Glucokinase links Krüppel‐like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

  2012influential reference
• The interaction of hepatic lipid and glucose metabolism in liver diseases.

  2012cited by this paper
• Carcinogen‐induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation

  2011cited by this paper
• Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

  2011cited by this paper
• The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-γ in the regulation of macrophage inflammatory protein-3α at early onset of diabetes.

  2011cited by this paper
• Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis.

  2011cited by this paper
• A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.

  2010cited by this paper
• Effect of miRNA‐10b in regulating cellular steatosis level by targeting PPAR‐α expression, a novel mechanism for the pathogenesis of NAFLD

  2010cited by this paper
• Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans

  2010cited by this paper
• Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease

  2010influential reference
• Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.

  2009cited by this paper
• Prostate-specific Klf6 Inactivation Impairs Anterior Prostate Branching Morphogenesis through Increased Activation of the Shh Pathway*

  2009cited by this paper
• Apoptosis is associated with CD36/fatty acid translocase upregulation in non‐alcoholic steatohepatitis

  2009influential reference
• Transcription factors Krüppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein.

  2009cited by this paper
• Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.

  2008cited by this paper
• Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

  2008cited by this paper
• PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.

  2008cited by this paper
• The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.

  2008cited by this paper
• Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome

  2008cited by this paper
• Peroxisome Proliferator-Activated Receptor-Alpha Deficiency Protects Aged Mice from Insulin Resistance Induced by High-Fat Diet

  2007cited by this paper
• Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

  2007cited by this paper
• Intronic microRNA precursors that bypass Drosha processing

  2007cited by this paper
• Krüppel-like Factor-6 Promotes Preadipocyte Differentiation through Histone Deacetylase 3-dependent Repression of DLK1*

  2005cited by this paper
• Regulation of carbohydrate metabolism by the farnesoid X receptor.

  2005cited by this paper
• Design and validation of a histological scoring system for nonalcoholic fatty liver disease

  2005cited by this paper
• PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

  2004cited by this paper
• PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

  2004cited by this paper
• Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.

  2003cited by this paper
• TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

  2003cited by this paper
• KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

  2001cited by this paper
• Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology

  2001cited by this paper
• DNA excision in liver by an albumin‐Cre transgene occurs progressively with age

  2000cited by this paper
• Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

  2000cited by this paper
• Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter.

  1998cited by this paper

• Coagulation protease-activated receptor-2 (PAR2) promotes dyslipidemia, obesity and MASLD through repression of the hepatic pioneer factor HNF4α

  2026cites this paper
• Liver Metabolism at the Crossroads: The Reciprocal Control of Nutrient-Sensing Nuclear Receptors and Autophagy

  2025cites this paper
• The possible renoprotective effect of denatonium benzoate in a rat model of type 2 diabetes: role of Krüppel-like factor 6 (KLF6).

  2025cites this paper
• Integrative ATAC‐seq and RNA‐seq analysis associated with diabetic nephropathy and identification of novel targets for treatment by dapagliflozin

  2024cites this paper
• Identification of genetic associations and functional SNPs of bovine KLF6 gene on milk production traits in Chinese holstein

  2023cites this paper
• Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology

  2023cites this paper
• KLF16 inhibits PEDV replication by activating the type I IFN signaling pathway.

  2022cites this paper
• Association between KLF6 rs3750861 polymorphism and plasma ceramide concentrations in post-menopausal women with type 2 diabetes.

  2022cites this paper
• Mechanistic insights into the peroxisome proliferator-activated receptor alpha as a transcriptional suppressor

  2022cites this paper
• The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma

  2021cites this paper
• The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

  2021cites this paper
• Lifestyle and preventive medical epigenetics

  2021cites this paper
• Current Options and Future Directions for NAFLD and NASH Treatment

  2021cites this paper
• PVT1 knockdown inhibited the biological behavior of LPS-induced cardiac fibroblasts by regulating miR-24

  2021cites this paper
• Non-coding RNA crosstalk with nuclear receptors in liver disease.

  2021cites this paper
• TransSynW: A single‐cell RNA‐sequencing based web application to guide cell conversion experiments

  2020cites this paper
• MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice

  2020cites this paper
• Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology

  2020cites this paper
• Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance

  2020cites this paper
• The roles of zinc finger proteins in non-alcoholic fatty liver disease

  2020cites this paper
• ERKRANKUNGEN DER VERDAUUNGSORGANE

  2020cites this paper
• Hepatocyte KLF6 expression affects FXR signalling and the clinical course of primary sclerosing cholangitis

  2020cites this paper
• Focal pancreatic lesions in autoimmune pancreatitis and weight loss

  2020cites this paper
• Klf6 protects β-cells against insulin resistance-induced dedifferentiation

  2020cites this paper
• New Trends in Vascular Inflammation Research: From Biology to Therapy

  2019influential citation
• Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation

  2019cites this paper
• Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease

  2018influential citation
• Dietary Modulation of the Epigenome.

  2018cites this paper
• Krüppel-Like Factors

  2018cites this paper
• Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

  2018cites this paper
• Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake

  2018cites this paper
• The Krüppel-Like Factors and Control of Energy Homeostasis.

  2018cites this paper
• Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease

  2018cites this paper
• Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

  2017cites this paper
• Elucidating fish oil-induced milk fat depression in dairy sheep: Milk somatic cell transcriptome analysis

  2017cites this paper
• University of Groningen Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury

  2017cites this paper
• SP and KLF Transcription Factors in Digestive Physiology and Diseases.

  2017cites this paper
• Krüppel-like factors in mammalian stem cells and development

  2017cites this paper
• p38α MAPK antagonizing JNK to control the hepatic fat accumulation in pediatric patients onset intestinal failure

  2017cites this paper
• Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.

  2017cites this paper
• Genomic Characterization of Metformin Hepatic Response

  2016cites this paper
• Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

  2016cites this paper
• Peroxisome Proliferator-Activated Receptor-γ and Its Ligands in the Treatment of Tumors in the Nervous System.

  2016cites this paper
• KLF6 contributes to myeloid cell plasticity in the pathogenesis of intestinal inflammation

  2016cites this paper
• Genetic background in nonalcoholic fatty liver disease: A comprehensive review.

  2015cites this paper
• Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis.

  2015cites this paper
• The activation of peroxisome proliferator-activated receptor γ is regulated by Krüppel-like transcription factors 6 & 9 under steatotic conditions.

  2015cites this paper
• KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

  2015cites this paper
• Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: relevance to nonalcoholic liver disease.

  2015cites this paper
• Immunological and molecular mechanisms in NAFLD

  2015cites this paper
• Non-Alcoholic Fatty Liver Disease – A Brief Insight into Pathogenesis and Review of Recent Reports on Therapeutic Targets

  2015cites this paper
• Modulation of cardiac fibrosis by Krüppel-like factor 6 through transcriptional control of thrombospondin 4 in cardiomyocytes.

  2015cites this paper
• Identifying Soluble Mediators of Nuclear Receptor and Insulin Signaling May Enhance Noninvasive Diagnosis of Fibrosis in Fatty Liver Disease

  2014cites this paper
• Regulation of microRNAs and their role in liver development, regeneration and disease.

  2014cites this paper
• The hunt for treatment options of fatty liver continues: Effects of retinoic acid on hepatic steatosis reveal novel transcriptional interactions of nuclear receptors

  2014cites this paper
• NASH: KLF6 activates PPARα signalling in hepatic steatosis

  2013cites this paper
• Gene expression in the vascular wall of the aortic arch in spontaneously hypertensive hyperlipidemic model rats using DNA microarray analysis.

  2013cites this paper