Redox regulation of Rac1 by thiol oxidation.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Free Radical Biology & Medicine

• Publication date

  2015-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.freeradbiomed.2014.09.027PMID 25289457PMCID PMC4708892
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rho GTPases, oxidation, and cell redox control

  2014cited by this paper
• Biophysical and proteomic characterization strategies for cysteine modifications in Ras GTPases.

  2014cited by this paper
• Rac1 cycling fast in melanoma with P29S

  2013cited by this paper
• RAC1P29S is a spontaneously activating cancer-associated GTPase

  2013cited by this paper
• Understanding the pK a of Redox Cysteines: The Key Role of Hydrogen Bonding

  2013cited by this paper
• Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments.

  2013influential reference
• Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo

  2013influential reference
• Mutationally activated Rho GTPases in cancer

  2013influential reference
• Regulation of small GTPases by GEFs, GAPs, and GDIs.

  2013cited by this paper
• Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein response.

  2013cited by this paper
• Glutathiolated Ras: characterization and implications for Ras activation.

  2013cited by this paper
• The role of palmitoylation in regulating Ras localization and function.

  2013cited by this paper
• Transforming mutations of RAC guanosine triphosphatases in human cancers

  2013cited by this paper
• Redox Regulation of Ras and Rho GTPases: Mechanism and Function

  2013cited by this paper
• Redox implications of AMPK-mediated signal transduction beyond energetic clues

  2012cited by this paper
• Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

  2012cited by this paper
• Rac1 in the driver’s seat for melanoma

  2012cited by this paper
• Serine-71 Phosphorylation of Rac1 Modulates Downstream Signaling

  2012cited by this paper
• A comprehensive survey of Ras mutations in cancer.

  2012cited by this paper
• Detection of Ras GTPase protein radicals through immuno-spin trapping.

  2012cited by this paper
• Protein S-glutathiolation: redox-sensitive regulation of protein function.

  2012cited by this paper
• Oxidation mimicking substitution of conservative cysteine in recoverin suppresses its membrane association

  2012cited by this paper
• Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.

  2012cited by this paper
• Rac signaling in breast cancer: a tale of GEFs and GAPs.

  2012influential reference
• A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity

  2011cited by this paper
• Regulation of protein tyrosine phosphatases by reversible oxidation.

  2011cited by this paper
• Regulatory Control or Oxidative Damage? Proteomic Approaches to Interrogate the Role of Cysteine Oxidation Status in Biological Processes*

  2011cited by this paper
• Tyrosine Phosphorylation of Rac1: A Role in Regulation of Cell Spreading

  2011cited by this paper
• The diverse roles of Rac signaling in tumorigenesis

  2011cited by this paper
• The 'invisible hand': regulation of RHO GTPases by RHOGDIs

  2011cited by this paper
• A palmitoylation switch mechanism regulates Rac1 function and membrane organization

  2011cited by this paper
• Purification of Reversibly Oxidized Proteins (PROP) Reveals a Redox Switch Controlling p38 MAP Kinase Activity

  2010cited by this paper
• SUMOylation of the GTPase Rac1 is required for optimal cell migration

  2010cited by this paper
• Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

  2010cited by this paper
• Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src

  2010cited by this paper
• Rac1 GTPase: A “Rac” of All Trades

  2009cited by this paper
• Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases

  2009influential reference
• Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

  2009cited by this paper
• Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

  2009influential reference
• Co‐regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac

  2008influential reference
• Rho GTPases in cancer cell biology

  2008influential reference
• Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases.

  2008cited by this paper
• Thiol chemistry and specificity in redox signaling.

  2008cited by this paper
• Tumour maintenance is mediated by eNOS

  2008cited by this paper
• Nitrite reduction to nitric oxide in the vasculature.

  2008cited by this paper
• SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.

  2008influential reference
• RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism.

  2008cited by this paper
• Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK‐regulated process

  2008cited by this paper
• Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival

  2008cited by this paper
• The effects of superoxide dismutase on H2O2 formation.

  2007influential reference
• A novel analytical method for in vivo phosphate tracking

  2006cited by this paper
• Rac1 GTPase Regulates Cell Genomic Stability and Senescence*

  2006cited by this paper
• S-Glutathiolation of p21ras by Peroxynitrite Mediates Endothelial Insulin Resistance Caused by Oxidized Low-Density Lipoprotein

  2006cited by this paper
• Genetic Deletion of Rac1 GTPase Reveals Its Critical Role in Actin Stress Fiber Formation and Focal Adhesion Complex Assembly*

  2006cited by this paper
• Involvement of Rac1 in Activation of Multicomponent Nox1- and Nox3-Based NADPH Oxidases

  2006influential reference
• Requirement of Rac1 in the development of cardiac hypertrophy.

  2006cited by this paper
• Free radical biology and medicine: it's a gas, man!

  2006cited by this paper
• Real-time in vitro measurement of GTP hydrolysis.

  2005cited by this paper
• How to study proteins by circular dichroism.

  2005cited by this paper
• ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth*

  2005cited by this paper
• Mechanism of free radical nitric oxide-mediated Ras guanine nucleotide dissociation.

  2005cited by this paper
• Mechanism of Redox-mediated Guanine Nucleotide Exchange on Redox-active Rho GTPases*

  2005influential reference
• S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide

  2004cited by this paper
• Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

  2004cited by this paper
• Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.

  2004cited by this paper
• Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange

  2003cited by this paper
• Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+ [1]

  2003cited by this paper
• Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaine.

  2003cited by this paper
• Backbone 1H, 13C, and 15N resonance assignments for the 21 kDa GTPase Rac1 complexed to GDP and Mg2+.

  2003cited by this paper
• The role of reactive oxygen species in homeostasis and degradation of cartilage.

  2003cited by this paper
• Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange*

  2002cited by this paper
• Regulation of Tiam1 Nucleotide Exchange Activity by Pleckstrin Domain Binding Ligands*

  2000cited by this paper
• Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1*

  2000cited by this paper
• Rac1 is required for the formation of three germ layers during gastrulation

  1998cited by this paper
• Ligand binding is the principal determinant of stability for the p21(H)-ras protein.

  1998cited by this paper
• The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

  1997cited by this paper
• NMRPipe: A multidimensional spectral processing system based on UNIX pipes

  1995cited by this paper
• Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.

  1995cited by this paper
• Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase.

  1994cited by this paper
• NMR View: A computer program for the visualization and analysis of NMR data

  1994cited by this paper
• Intracellular localization of the P21rho proteins

  1992cited by this paper
• The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

  1992cited by this paper
• Post-translational modifications of p21rho proteins.

  1992cited by this paper
• The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

  1992cited by this paper
• Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

  1990cited by this paper
• Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

  1987cited by this paper
• Serveur Académique Lausannois SERVAL serval.unil.ch

  year unknowncited by this paper

• Redox Control in Platelet Activity and Therapy

  2025cites this paper
• Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors.

  2023cites this paper
• Role of a small GTPase Cdc42 in aging and age-related diseases

  2023cites this paper
• Bradykinin promotes murine melanoma cell migration and invasion through endogenous production of superoxide and nitric oxide.

  2023cites this paper
• A Role for Second Messengers in Axodendritic Neuronal Polarity

  2023cites this paper
• ROS produced by NOX promote the neurite growth in a PI3K/Akt independent manner

  2023cites this paper
• Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

  2022cites this paper
• Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition

  2022cites this paper
• Rho GTPases: Non‐canonical regulation by cysteine oxidation

  2021cites this paper
• Nitric Oxide and Electrophilic Cyclopentenone Prostaglandins in Redox signaling, Regulation of Cytoskeleton Dynamics and Intercellular Communication

  2021cites this paper
• ROS regulation of RAS and vulva development in Caenorhabditis elegans

  2020cites this paper
• The proteomic landscape of cysteine oxidation that underpins retinoic acid-induced neuronal differentiation.

  2020cites this paper
• The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2

  2020cites this paper
• Discoveries in the redox regulation of KRAS.

  2020cites this paper
• Phosphorylated cofilin-2 is more prone to oxidative modifications on Cys39 and favors amyloid fibril formation

  2020cites this paper
• Neurodevelopmental Disorders

  2019cites this paper
• Loss of ATM Positively Regulates Rac1 Activity and Cellular Migration Through Oxidative Stress

  2019cites this paper
• Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects.

  2019cites this paper
• Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity

  2019cites this paper
• Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

  2018cites this paper
• Crosstalk between Rac1-mediated actin regulation and ROS production.

  2018cites this paper
• Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

  2018cites this paper
• Assessment of S-Glutathionylated Rac1 in Cells Using Biotin-Labeled Glutathione.

  2018cites this paper
• ROLE OF THIOLS IN OXIDATIVE STRESS.

  2018cites this paper
• Effects of antioxidant supplementation on cancer progression

  2018cites this paper
• Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

  2018cites this paper
• Redox regulation of the actin cytoskeleton and its role in the vascular system

  2017influential citation
• RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes.

  2017cites this paper
• Targeting a Common Enemy: Toxic Cellular Mechanism of Novel Anti-cancer Agents that Alter DNA and Transcription

  2016cites this paper
• Thiyl radicals and induction of protein degradation

  2016cites this paper
• Metabolic rewiring in melanoma

  2016cites this paper
• Treatment effect of Low Intensity Pulsed Ultrasound either alone, with functional appliance and with gene therapy on the mandibular condylar growth

  2016cites this paper
• The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

  2016cites this paper
• The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signaling, and their interplay

  2015cites this paper
• Antioxidants can increase melanoma metastasis in mice

  2015cites this paper
• Rac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog

  2015cites this paper
• Protein thiyl radical reactions and product formation: a kinetic simulation

  2014cites this paper