Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Free Radical Biology & Medicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.freeradbiomed.2012.10.556PMID 23142420PMCID PMC3539142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals.

  2012cited by this paper
• Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.

  2012cited by this paper
• The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.

  2011cited by this paper
• Phospholipase A2 Activity of Peroxiredoxin 6 Promotes Invasion and Metastasis of Lung Cancer Cells

  2010cited by this paper
• Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.

  2009cited by this paper
• Novel Role for Glutathione S-Transferase π

  2009cited by this paper
• Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin.

  2008cited by this paper
• Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer

  2007cited by this paper
• S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response.

  2007cited by this paper
• Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes.

  2006cited by this paper
• The isoenzymes of glutathione transferase.

  2006cited by this paper
• Identification of breast cancer metastasis‐associated proteins in an isogenic tumor metastasis model using two‐dimensional gel electrophoresis and liquid chromatography‐ion trap‐mass spectrometry

  2006cited by this paper
• A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins

  2006cited by this paper
• Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism.

  2005cited by this paper
• Single Nucleotide Polymorphism of Pi-Class Glutathione S-Transferase and Susceptibility to Endometrial Carcinoma

  2005cited by this paper
• Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.

  2004cited by this paper
• Peroxiredoxins in breast carcinoma.

  2003cited by this paper
• 1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage

  2002cited by this paper
• Catalytic efficiencies of allelic variants of human glutathione S-transferase Pi in the glutathione conjugation of alpha, beta-unsaturated aldehydes.

  2000cited by this paper
• Catalytic efficiencies of allelic variants of human glutathione S-transferase Pi in the glutathione conjugation of α,β-unsaturated aldehydes

  2000cited by this paper
• Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.

  1999cited by this paper
• Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells.

  1999cited by this paper
• Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution.

  1998cited by this paper
• Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.

  1998cited by this paper
• Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients.

  1998cited by this paper
• Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.

  1997cited by this paper
• Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

  1997cited by this paper
• The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

  1995cited by this paper
• Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.

  1994cited by this paper
• Nomenclature for human glutathione transferases.

  1992cited by this paper

• TXNIP-Deficiency and Prdx6 Delivery Inhibit Aging/Oxidative Stress-Driven TXNIP-Nlrp3 Inflammasome Activation and Mitigate Pyroptosis in Lens Epithelial Cells.

  2026cites this paper
• GSTP1 and GSTO1 Variant Alleles Affect Susceptibility to Helicobacter pylori Infection and Severity of Helicobacter pylori-Associated Clinical Manifestations

  2025cites this paper
• Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment

  2025cites this paper
• Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging

  2025cites this paper
• Isozyme-specific inhibition of GSTP1-1: a crucial element in cancer-targeting drugs.

  2025cites this paper
• Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species.

  2024cites this paper
• The Multifaceted Role of Glutathione S-Transferases in Health and Disease

  2023cites this paper
• SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation.

  2023cites this paper
• S‑Glutathionylation and S‑Nitrosylation as Modulators of Redox-Dependent Processes in Cancer Cell

  2023cites this paper
• The essential role of GSTP1 I105V polymorphism in the prediction of CDNB metabolism and toxicity: In silico and in vitro insights.

  2023cites this paper
• Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients

  2023cites this paper
• Low Xanthophylls, Retinol, Lycopene, and Tocopherols in Grey and White Matter of Brains with Alzheimer’s Disease

  2022cites this paper
• Role of Glutathione S Transferase Polymorphism in the Pathogenesis of Cardiovascular Diseases. A Case Control Study

  2022cites this paper
• Glutathione S-Transferases in Cancer

  2021cites this paper
• Metabolic pathways in sporadic colorectal carcinogenesis: A new proposal.

  2021cites this paper
• Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems

  2021cites this paper
• Activity of glutathione S-transferase and its π isoenzyme in the context of single nucleotide polymorphism in the GSTP1 gene (rs1695) and tobacco smoke exposure in the patients with acute pancreatitis and healthy subjects.

  2021cites this paper
• The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

  2021cites this paper
• Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish

  2021cites this paper
• Oxidative Modification of Proteins: From Damage to Catalysis, Signaling, and Beyond

  2021cites this paper
• S -Glutathionylation of estrogen receptor (cid:2) affects dendritic cell function

  2020cites this paper
• Development of Telintra as an Inhibitor of Glutathione S-Transferase P.

  2020cites this paper
• Altered Redox Regulation and S-Glutathionylation of BiP Contribute to Bortezomib Resistance in Multiple Myeloma.

  2020cites this paper
• Human variability in Glutathione-S-Transferase activities, tissue distribution and major polymorphic variants: meta-analysis and implication for chemical risk assessment.

  2020cites this paper
• Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury.

  2019cites this paper
• Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy.

  2019cites this paper
• 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish

  2019cites this paper
• Glutathione Transferase P1 Polymorphism Might Be a Risk Determinant in Heart Failure

  2019cites this paper
• 4-Bromo-1,8-naphthalimide derivatives as fluorogenic substrates for live cell imaging of glutathione S-transferase (GST) activity.

  2019cites this paper
• Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish

  2019cites this paper
• An evolving understanding of the S‐glutathionylation cycle in pathways of redox regulation

  2018cites this paper
• Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

  2018cites this paper
• S -Glutathionylation of estrogen receptor alpha affects dendritic cell function

  2018cites this paper
• Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.

  2018cites this paper
• S-Glutathionylation of estrogen receptor α affects dendritic cell function

  2018cites this paper
• Mitigating effects of pollen during paraquat exposure on gene expression and pathogen prevalence in Apis mellifera L

  2017cites this paper
• The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy

  2017cites this paper
• Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling.

  2017cites this paper
• Differential carbonylation of proteins in end‐stage human fatty and nonfatty NASH

  2017cites this paper
• Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

  2016cites this paper
• The Antioxidant Peroxiredoxin 6 (Prdx6) Exhibits Different Profiles in the Livers of Seawater- and Fresh Water-Acclimated Milkfish, Chanos chanos, upon Hypothermal Challenge

  2016cites this paper
• Combined GSTM1-Null, GSTT1-Active, GSTA1 Low-Activity and GSTP1-Variant Genotype Is Associated with Increased Risk of Clear Cell Renal Cell Carcinoma

  2016cites this paper
• Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase

  2016cites this paper
• The cysteine proteome.

  2015cites this paper
• Oxidative stress, redox regulation and diseases of cellular differentiation.

  2015cites this paper
• Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides.

  2015cites this paper
• Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.

  2015cites this paper
• A novel 1-Cys thioredoxin peroxidase gene in Apis cerana cerana: characterization of AccTpx4 and its role in oxidative stresses

  2015cites this paper
• Engineered cytochrome P450 BM3 mutants as biocatalysts for metabolite production: Applications in biotechnology and toxicology

  2014cites this paper
• Peroxiredoxin VI Oxidation in Cerebrospinal Fluid Correlates with TBI Outcome

  2014cites this paper
• Blood thiol status and erythrocyte glutathione-S-transferase in chronic kidney disease patients on treatment with frequent (daily) hemodialysis

  2014cites this paper
• Genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes and lung cancer susceptibility in the Bangladeshi population

  2014cites this paper
• Glutathione and redox signaling in substance abuse.

  2014cites this paper
• EFFECT OF Artemisia vulgaris LEAF EXTRACT ON ANTIOXIDANT STATUS OF PRIMARY CHICK EMBRYO FIBROBLASTS

  2014cites this paper
• Pleiotropic functions of glutathione S-transferase P.

  2014cites this paper
• In vivo regulation of human glutathione transferase GSTP by chemopreventive agents.

  2014cites this paper
• Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.

  2014cites this paper
• Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.

  2014cites this paper
• Role of genetic polymorphisms of drug metabolising enzymes in idiosyncratic drug reactions In vitro to in vivo translation

  2013cites this paper
• Glutathione S-Transferase T1, O1 and O2 Polymorphisms Are Associated with Survival in Muscle Invasive Bladder Cancer Patients

  2013cites this paper
• Causes and Consequences of Cysteine S-Glutathionylation*

  2013influential citation
• Free Radical Biology and Medicine

  2012cites this paper