Intravenously administered nanoparticles increase survival following blast trauma

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-06-30

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1073/pnas.1406979111PMID 24982180PMCID PMC4104920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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• Novel method for concentrating and drying polymeric nanoparticles: hydrogen bonding coacervate precipitation.

  2010cited by this paper
• Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility.

  2009cited by this paper
• Intravenous Hemostat: Nanotechnology to Halt Bleeding

  2009cited by this paper
• Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.

  2007cited by this paper
• Partition identities and Ramanujan's modular equations

  2007cited by this paper
• Military TBI During the Iraq and Afghanistan Wars

  2006cited by this paper
• Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.

  2006cited by this paper
• Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma.

  2006cited by this paper
• Blast injuries.

  2005cited by this paper
• Use of Recombinant Factor VIIa for Adjunctive Hemorrhage Control in Trauma and Surgical Patients

  2005cited by this paper
• Hemostatic effects of phospholipid vesicles carrying fibrinogen gamma chain dodecapeptide in vitro and in vivo.

  2005cited by this paper
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  2005cited by this paper
• CURRENT CONCEPTS blast injuries

  2005cited by this paper
• Blast injuries.

  2005cited by this paper
• Treating traumatic bleeding in a combat setting: possible role of recombinant activated factor VII.

  2004cited by this paper
• A profile of combat injury.

  2003cited by this paper
• Blood transfusion, independent of shock severity, is associated with worse outcome in trauma.

  2003cited by this paper
• Explosions and blast injuries.

  2001cited by this paper
• The global burden of injuries.

  2000cited by this paper
• Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits

  1999cited by this paper
• Toxicology of blast overpressure.

  1997cited by this paper
• The pathology of primary blast overpressure injury.

  1997influential reference
• Prehospital care, importance of early intervention on outcome

  1997cited by this paper
• Thromboerythrocytes. In vitro studies of a potential autologous, semi-artificial alternative to platelet transfusions.

  1992cited by this paper

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• Emerging Materials for Hemostasis

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• Nanoparticle-based drug delivery for the treatment of traumatic brain injury

  2022cites this paper
• Intravenous Hemostats: Foundation, Targeting, and Controlled-Release.

  2022cites this paper
• Artificial Cells: Past, Present and Future.

  2022cites this paper
• A review of treatments for non-compressible torso hemorrhage (NCTH) and internal bleeding.

  2022cites this paper
• Biomaterials as Haemostatic Agents in Cardiovascular Surgery: Review of Current Situation and Future Trends

  2022cites this paper
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  2022cites this paper
• New Biologicals to Assist Clotting

  2021cites this paper
• Hemostatic strategies for uncontrolled bleeding: A comprehensive update.

  2021cites this paper
• Nanomedicines for hemorrhage control

  2021cites this paper
• Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury

  2021cites this paper
• Getting to the Core of It All: Nanocapsules to Mitigate Infusion Reactions Can Promote Hemostasis and Be a Platform for Intravenous Therapies.

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  2021cites this paper
• Self-sealing hemostatic and antibacterial needles by polyphenol-assisted surface self-assembly of multifunctional nanoparticles

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• Platelet Transfusion—Insights from Current Practice to Future Development

  2021cites this paper
• Synthesis of chitosan iodoacetamides via carbodiimide coupling reaction: Effect of degree of substitution on the hemostatic properties.

  2020cites this paper
• Peptide-based topical agents and intravenous hemostat for rapid hemostasis.

  2020cites this paper
• Synthetic Blood Substitutes

  2020cites this paper
• Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal

  2020cites this paper
• Hemostatic agents for prehospital hemorrhage control: a narrative review

  2020cites this paper
• Systemically Administered Hemostatic Nanoparticles for Identification and Treatment of Internal Bleeding.

  2019cites this paper
• Emerging Therapies for Prehospital Control of Hemorrhage.

  2019cites this paper
• Nanoparticles in foods? A multiscale physiopathological investigation of iron oxide nanoparticle effects on rats after an acute oral exposure: Trace element biodistribution and cognitive capacities.

  2019cites this paper
• Recent Advances in Hemostasis at the Nanoscale

  2019cites this paper
• Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting

  2019cites this paper
• Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides

  2019cites this paper
• The Chemistry of Lyophilized Blood Products.

  2018cites this paper
• Nano- and micro-materials in the treatment of internal bleeding and uncontrolled hemorrhage.

  2018influential citation
• Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels.

  2018cites this paper
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  2018cites this paper
• Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma.

  2018cites this paper
• Hemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma model

  2018cites this paper
• Platelet transfusion: Current challenges.

  2018cites this paper
• GRGDS-functionalized chitosan nanoparticles as a potential intravenous hemostat for traumatic hemorrhage control in an animal model.

  2018cites this paper
• Improving the efficacy of hemostatic agents by increasing their transport into wounds

  2018cites this paper
• Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding

  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• Non-affinity factors modulating vascular targeting of nano- and microcarriers.

  2016cites this paper
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