Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jaci.2012.07.017PMID 22947346PMCID PMC3578224
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2009cited by this paper
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  2008cited by this paper
• Severe asthma: lessons from the Severe Asthma Research Program.

  2007cited by this paper
• Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma

  2007cited by this paper
• Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.

  2006cited by this paper
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  2006cited by this paper
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  2005cited by this paper
• Severe asthma treatment: need for characterising patients.

  2005cited by this paper
• Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper

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  2021cites this paper
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