[The use of the vancomycin paste for sternal hemostasis and mediastinitis prophylaxis].

INTRODUCTION Mediastinitis is one of the most feared complications for thoracic surgeons, being a significant factor in morbidity and mortality in thoracic surgery. OBJECTIVE To find a new alternative in order to prevent mediastinitis, reducing the morbidity and mortality. METHODS A retrospective study including 1020 patients operated between February 2002 and October 2005. Patients underwent bypass surgery and vancomycin paste was used rather than bone wax in all cases. RESULTS Patients were followed-up for 45 months; there were only five (0.49%) cases of mediastinitis; no deaths were observed. CONCLUSION The use of Vancomycin paste to replace bone wax proved to be a great allied to prevent mediastinitis after thoracic surgery.

• Publication year

  2008

• Venue

  Revista Brasileira De Cirurgia Cardiovascular

• Publication date

  2008-02-26

• Fields of study

  Medicine

• Identifiers
  DOI 10.1590/S0102-76382008000100007PMID 18719826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CHEST WALL ABNORMALITIES

  2006cited by this paper
• Determination of antibiotic levels in human bone: I. Gentamicin levels in bone

  2005cited by this paper
• Prophylaxis of sternal wound infections with gentamicin-collagen implant: randomized controlled study in cardiac surgery.

  2005cited by this paper
• The impact of new preventive measures and treatment of surgical site infections after coronary artery bypass graft surgery

  2005cited by this paper
• Risk factors for mediastinitis after cardiac surgery.

  2004cited by this paper
• Simplified treatment of postoperative mediastinitis.

  2004cited by this paper
• Preditores de mediastinite em cirurgia cardíaca

  2004cited by this paper
• Predictors of mediastinitis after cardiac surgery

  2004cited by this paper
• Topical vancomycin applied on closure of the sternotomy wound does not prevent high levels of systemic vancomycin.

  2003cited by this paper
• Mediastinite pós-esternotomia longitudinal para cirurgia cardíaca: 10 anos de análise

  2002cited by this paper
• Mediastinite no Hospital de Base do Distrito Federal: incidência em seis anos

  2002cited by this paper
• Transxiphoid approach without median sternotomy for the repair of atrial septal defects.

  1998cited by this paper
• Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass.

  1996cited by this paper
• Postoperative mediastinitis: classification and management.

  1996cited by this paper
• Prescribing exercise in multiple short bouts versus one continuous bout: effects on adherence, cardiorespiratory fitness, and weight loss in overweight women.

  1995cited by this paper
• O cimento ortopédico associado a vancomicina: estudo de seu comportamento mecânico e da difusão do antibiótico em meio líquido

  1994cited by this paper
• Penetration of vancomycin in uninfected sternal bone

  1992cited by this paper
• Glenn's Thoracic and Cardiovascular Surgery

  1991cited by this paper
• Reduction of sternal infection by application of topical vancomycin.

  1989cited by this paper
• Antibiotic-loaded acrylic cement: current concepts.

  1984cited by this paper
• Postoperative median sternotomy dehiscence.

  1983cited by this paper
• Bone Concentrations of Antimicrobial Agents After Parenteral Administration

  1976cited by this paper

• Immunonutritional Markers and the Protective Role of Sternal Irrigation and Antibiotic-Impregnated Membranes in Sternal Wound Infection: A Retrospective Cohort Study

  2025cites this paper
• A meta‐analysis examined the effect of topical vancomycin application in decreasing sternal wound infections post cardiac surgery

  2023cites this paper
• Topical vancomycin for sternal wound infection prophylaxis. A systematic review and updated meta-analysis of over 40,000 cardiac surgery patients.

  2023cites this paper
• Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CI

  2021cites this paper
• Dual Topical Antibiotic Application Prior to Sternotomy Closure Reduces Sternal Wound Infection Rates: A Simple Solution to a Grave Morbidity.

  2021cites this paper
• Computed Tomography Imaging Assessment of the Effect of Vancomycin Paste on Poststernotomy Healing

  2021cites this paper
• Evaluation of poly (ethylene glycol–propylene glycol) copolymer bone hemostatic agent containing gentamicin for enhancing local antibacterial and anti-inflammatory effects in an infected calvarial defect rat model

  2021cites this paper
• Topical Vancomycin and Risk of Sternal Wound Infections: A Double-Blind Randomized Controlled Trial.

  2021cites this paper
• Deep Sternal Wound Infections After Cardiac Surgery: A New Australian Tertiary Centre Experience.

  2020cites this paper
• Vancomycin Local application, role in Deep Sternal Wound Infection in our experience

  2020cites this paper
• Topical vancomycin for neurosurgery wound prophylaxis: an interim report of a randomized clinical trial on drug safety in a diverse neurosurgical population.

  2019cites this paper
• Topical use of Vancomycin in Craniotomy

  2019cites this paper
• Surgical Treatment of the Thoracic Aorta

  2019cites this paper
• Empleo de vancomicina tópica en la profilaxis de infección de herida de esternotomía: experiencia inicial

  2018cites this paper
• Bone Wax in Neurosurgery: A Review.

  2018cites this paper
• Vancomycin Paste and Sternal Wound Infections.

  2018cites this paper
• Bone Wax in Neurosurgery : A Review

  2018cites this paper
• Use of Vancomycin in the Prevention of Superficial and Deep Infections afterSternotomy

  2018cites this paper
• Topical vancomycin to reduce surgical-site infections in neurosurgery: Study protocol for a multi-center, randomized controlled trial.

  2018cites this paper
• A review of the AATS guidelines for the prevention and management of sternal wound infections

  2018cites this paper
• Meta‐analysis to assess the effectiveness of topically used vancomycin in reducing sternal wound infections after cardiac surgery

  2017cites this paper
• Vancomycin Paste Does Not Reduce the Incidence of Deep Sternal Wound Infection After Cardiac Operations.

  2017cites this paper
• Technique for Placement of Peri-Implant Antibiotics Using Antibiotic Putty.

  2017cites this paper
• [Infections in cardiac surgery].

  2016cites this paper
• Prevention and management of sternal wound infections.

  2016cites this paper
• Adjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model

  2015cites this paper
• Is it possible to prevent morbidity on post cardiovascular surgery applying low level laser therapy?

  2014cites this paper
• Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections.

  2014cites this paper
• Toward zero: deep sternal wound infection after 1001 consecutive coronary artery bypass procedures using arterial grafts: implications for diabetic patients.

  2014cites this paper
• Mediastinitis: mortality rate comparing single-stage surgical approach and preconditioning of wound Mediastinite: mortalidade comparando abordagem cirúrgica em tempo único e o pré-condicionamento da ferida operatória

  2013cites this paper
• Mediastinitis: mortality rate comparing single-stage surgical approach and preconditioning of wound.

  2013cites this paper
• Use of Incisional Vancomycin in Spine Surgery

  2013cites this paper
• Local Antimicrobial Administration for Prophylaxis of Surgical Site Infections

  2012cites this paper
• Skeletonized internal thoracic artery is associated with lower rates of mediastinitis in elderly undergoing coronary artery bypass grafting surgery.

  2011cites this paper
• Skeletonized left internal thoracic artery is associated with lower rates of mediastinitis in diabetic patients.

  2011cites this paper
• Geli Putty®: a new alternative on sternal hemostasis in cardiac surgery.

  2011cites this paper