Growth hormone delivery devices: current features and potential for enhanced treatment adherence

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Expert Opinion on Drug Delivery

• Publication date

  2017-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1080/17425247.2017.1243526PMID 27718757
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Adherence to Growth Hormone Therapy: A Practical Approach

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• Adherence to growth hormone therapy: results of a multicenter study.

  2014cited by this paper
• Results from an international multicenter trial evaluating the ease-of-use of and preference for a newly developed disposable injection pen for the treatment of growth hormone deficiency in treatment-naïve children and adults

  2014influential reference
• Validation and ease of use of a new pen device for self-administration of recombinant human growth hormone: results from a two-center usability study

  2013influential reference
• Transjecting growth hormone: continuous nightmare or controlled nuisance? Evaluation of a new needle-free device

  2013cited by this paper
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• Administration burden associated with recombinant human growth hormone treatment: perspectives of patients and caregivers.

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• Comparison of injection dose force, accuracy and precision among three growth hormone injection devices

  2013influential reference
• Comparison of intuitiveness, ease of use and preference among three prefilled, disposable growth hormone injection pens

  2013influential reference
• Initiating growth hormone therapy for children and adolescents.

  2012cited by this paper
• Identification and management of poor response to growth‐promoting therapy in children with short stature

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• Children and adolescent acceptability of a new device system to administer human growth hormone – a pilot study

  2012cited by this paper
• Consequences of brand switches during the course of pediatric growth hormone treatment.

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  2011influential reference
• The benefits of growth hormone therapy in patients with Turner syndrome, Noonan syndrome and children born small for gestational age.

  2011cited by this paper
• Medication adherence: WHO cares?

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• Developments in administration of growth hormone treatment: focus on Norditropin® Flexpro®

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• [Compliance, concordance, adherence].

  2010cited by this paper
• Cost minimization analysis of different growth hormone pen devices based on time-and-motion simulations

  2010cited by this paper
• Ease of use and preference for a new disposable self-injection pen compared with a reusable pen for administering recombinant human growth hormone: A multicenter, 2-month, single-arm, open-label clinical trial in patient-caregiver dyads.

  2010influential reference
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation.

  2010cited by this paper
• Intuitiveness, ease of use, and preference of a prefilled growth hormone injection pen: a noninterventional, randomized, open-label, crossover, comparative usability study of three delivery devices in growth hormone-treated pediatric patients.

  2010influential reference
• Current indications for growth hormone therapy for children and adolescents.

  2010influential reference
• The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency.

  2010cited by this paper
• Adherence remains a challenge for patients receiving growth hormone therapy.

  2009cited by this paper
• Ease of use and acceptability of a new pen device for the administration of growth hormone therapy in pediatric patients: an open-label, uncontrolled usability test.

  2009influential reference
• Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency.

  2009cited by this paper
• User trial of Easypod, an electronic autoinjector for growth hormone.

  2008cited by this paper
• Compliance and persistence in pediatric and adult patients receiving growth hormone therapy.

  2008cited by this paper
• Observations of nonadherence to recombinant human growth hormone therapy in clinical practice.

  2008influential reference
• Interventions for enhancing medication adherence.

  2008cited by this paper
• Easypod™ a new electronic injection device for growth hormone

  2008cited by this paper
• Factors affecting therapeutic compliance: A review from the patient’s perspective

  2008cited by this paper
• Comparison of human growth hormone products' cost in pediatric and adult patients. A budgetary impact model.

  2007cited by this paper
• Facilitating and understanding the family’s choice of injection device for growth hormone therapy by using conjoint analysis

  2007cited by this paper
• Compliance, concordance, adherence.

  2007cited by this paper
• BMC Clinical Pharmacology BioMed Central

  2007cited by this paper
• Monitoring of concordance in growth hormone therapy

  2007cited by this paper
• Patient acceptance of a novel electronic auto-injector device to administer recombinant human growth hormone: results from an open-label, user survey of everyday use

  2007influential reference
• Pain perception after subcutaneous injections of media containing different buffers.

  2006cited by this paper
• Pain following controlled cutaneous insertion of needles with different diameters

  2006cited by this paper
• Factors Determining Patient Choice of Device for GH Therapy

  2006cited by this paper
• Understanding and meeting the needs of those using growth hormone injection devices

  2006cited by this paper
• Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline.

  2006cited by this paper
• Adherence to medication.

  2005cited by this paper
• Adherence to medication.

  2005cited by this paper
• Patient outcomes in the GHMonitor: the effect of delivery device on compliance and growth.

  2005cited by this paper
• Liquid Growth Hormone: Preservatives and Buffers

  2004influential reference
• Are Needle-Free Injections a Useful Alternative for Growth Hormone Therapy in Children? Safety and Pharmacokinetics of Growth Hormone Delivered by a New Needle-Free Injection Device Compared to a Fine Gauge Needle

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  1999cited by this paper
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  1998cited by this paper
• Patient evaluation of a new injection pen for growth hormone treatment in children and adults

  1995cited by this paper
• Compliance with growth hormone treatment--are they getting it?

  1995cited by this paper
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  1995cited by this paper
• Compliance with growth hormone treatment--are they getting it?

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Optimum method for administration of biosynthetic human growth hormone: a randomised crossover trial of an Auto Injector and a pen injection system.

  1992cited by this paper
• Growth hormone therapy with a new delivery system

  1991cited by this paper
• Evaluation of a pen injector system for growth hormone treatment.

  1991cited by this paper
• Skeletal muscle performance in adults with growth hormone deficiency.

  1990influential reference
• Simplified Growth Hormone Therapy — First Clinical Experience with the KabiPen

  1988influential reference
• Comparison of dose frequency of human growth hormone in treatment of organic and idiopathic hypopituitarism.

  1987cited by this paper
• Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children.

  1983cited by this paper

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