Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract. GISTs have very different clinical phenotypes and underlying molecular characteristics that are not yet completely understood. microRNAs (miRNAs) have been shown to participate in carcinogenesis pathways through post-transcriptional regulation of gene expression in different tumors. Over the last years emerging evidence has highlighted the role of miRNAs in GISTs. This review provides an overview of original research papers that analyze miRNA deregulation patterns, functional role, diagnostic, therapeutic and prognostic implications in GIST as well as provides directions for further research in the field.

• Publication year

  2018

• Venue

  International Journal of Molecular Sciences

• Publication date

  2018-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms19020397PMID 29385688PMCID 5855619
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Survivin is a novel transcription regulator of KIT and is downregulated by miRNA‐494 in gastrointestinal stromal tumors

  2018cited by this paper
• Race Disparities in the Contribution of miRNA Isoforms and tRNA-Derived Fragments to Triple-Negative Breast Cancer.

  2018cited by this paper
• The incidence, mutational status, risk classification and referral pattern of gastro-intestinal stromal tumours in the Netherlands: a nationwide pathology registry (PALGA) study

  2018cited by this paper
• miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth.

  2017cited by this paper
• Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma

  2017cited by this paper
• Emergence of miR-34a in radiation therapy.

  2017cited by this paper
• Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer

  2017cited by this paper
• MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing

  2017cited by this paper
• Targeting MicroRNAs in Cancer Gene Therapy

  2017cited by this paper
• Diagnosis of eosinophilic gastroenteritis is easily missed

  2017cited by this paper
• A comprehensive, cell specific microRNA catalogue of human peripheral blood

  2017cited by this paper
• Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors

  2017cited by this paper
• A systematic review and network meta-analysis of post-imatinib therapy in advanced gastrointestinal stromal tumour.

  2017cited by this paper
• Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs)

  2017cited by this paper
• RETRACTED: MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor

  2017cited by this paper
• Genetic Polymorphisms Contribute to the Individual Variations of Imatinib Mesylate Plasma Levels and Adverse Reactions in Chinese GIST Patients

  2017cited by this paper
• The Pattern of microRNA Binding Site Distribution

  2017cited by this paper
• Naturally existing isoforms of miR-222 have distinct functions

  2017cited by this paper
• Identification of circulating microRNA signatures as potential noninvasive biomarkers for prediction and prognosis of lymph node metastasis in gastric cancer

  2017cited by this paper
• Gastric GISTs: Analysis of c-Kit, PDGFRA and BRAF mutations in relation to prognosis and clinical pathological characteristics of patients - A GIRCG study.

  2016cited by this paper
• miRNA-21 sensitizes gastrointestinal stromal tumors (GISTs) cells to Imatinib via targeting B-cell lymphoma 2 (Bcl-2).

  2016cited by this paper
• Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma

  2016cited by this paper
• PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor

  2016cited by this paper
• Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients.

  2016cited by this paper
• miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer.

  2016cited by this paper
• Epigenetic silencing of miR‐137 is a frequent event in gastric carcinogenesis

  2016cited by this paper
• miRNA-21 and miRNA-34a Are Potential Minimally Invasive Biomarkers for the Diagnosis of Pancreatic Ductal Adenocarcinoma

  2016cited by this paper
• miR-494 suppresses tumor growth of epithelial ovarian carcinoma by targeting IGF1R

  2016cited by this paper
• Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells.

  2016cited by this paper
• Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors.

  2016influential reference
• Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations

  2016cited by this paper
• miRNA profiling in gastrointestinal stromal tumors: implication as diagnostic and prognostic markers.

  2015cited by this paper
• MicroRNA Therapeutics: the Next Magic Bullet?

  2015influential reference
• miRNA‐221 and miRNA‐222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours

  2015cited by this paper
• Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis

  2015cited by this paper
• A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors

  2015influential reference
• microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway

  2015cited by this paper
• Epstein‐Barr virus infection induces miR‐21 in terminally differentiated malignant B cells

  2015cited by this paper
• miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN.

  2015cited by this paper
• Gastrointestinal Stromal Tumours: Review of 150 Cases from a Single Centre

  2015cited by this paper
• Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray.

  2015cited by this paper
• Correction: Analysis of Deregulated microRNAs and Their Target Genes in Gastric Cancer

  2015cited by this paper
• Analysis of Deregulated microRNAs and Their Target Genes in Gastric Cancer

  2015cited by this paper
• microRNA expression signatures of gastrointestinal stromal tumours: associations with imatinib resistance and patient outcome

  2014cited by this paper
• Increased Circulating MicroRNA-155 as a Potential Biomarker for Breast Cancer Screening: A Meta-Analysis

  2014cited by this paper
• High throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry

  2014cited by this paper
• A Novel miR-451a isomiR, Associated with Amelanotypic Phenotype, Acts as a Tumor Suppressor in Melanoma by Retarding Cell Migration and Invasion

  2014cited by this paper
• Molecular diagnostics in gastric cancer.

  2014cited by this paper
• MicroRNA-218 inhibits gastrointestinal stromal tumor cell and invasion by targeting KIT

  2014cited by this paper
• Gene Polymorphisms of Micrornas in Helicobacter pylori-Induced High Risk Atrophic Gastritis and Gastric Cancer

  2014cited by this paper
• Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer

  2014cited by this paper
• MiRNA detection at single-cell resolution using microfluidic LNA flow-FISH.

  2014cited by this paper
• The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment

  2014cited by this paper
• miR-137 regulates epithelial-mesenchymal transition in gastrointestinal stromal tumor

  2014cited by this paper
• Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor

  2013influential reference
• Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples

  2013cited by this paper
• MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours

  2013cited by this paper
• Post-Transcriptional Dysregulation by miRNAs Is Implicated in the Pathogenesis of Gastrointestinal Stromal Tumor [GIST]

  2013cited by this paper
• MicroRNA in gastrointestinal cancer: a step closer to reality.

  2013influential reference
• MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation

  2012cited by this paper
• The microcosmos of cancer

  2012cited by this paper
• miRNA arm selection and isomiR distribution in gastric cancer

  2012cited by this paper
• miR221/222 in cancer: their role in tumor progression and response to therapy.

  2012cited by this paper
• Macro-Role of MicroRNA in Gastric Cancer

  2012cited by this paper
• Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.

  2012cited by this paper
• MicroRNAs and their isomiRs function cooperatively to target common biological pathways

  2011cited by this paper
• MicroRNA-494 Downregulates KIT and Inhibits Gastrointestinal Stromal Tumor Cell Proliferation

  2011cited by this paper
• Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors.

  2011cited by this paper
• microRNA profiling in Epstein–Barr virus-associated B-cell lymphoma

  2010cited by this paper
• MicroRNA expression profile of gastrointestinal stromal tumors is distinguished by 14q loss and anatomic site

  2010influential reference
• Target RNA–Directed Trimming and Tailing of Small Silencing RNAs

  2010cited by this paper
• Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST

  2010cited by this paper
• Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.

  2010cited by this paper
• MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2

  2010cited by this paper
• P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

  2010cited by this paper
• MicroRNA expression signature of human sarcomas

  2008influential reference
• Circulating microRNAs as stable blood-based markers for cancer detection

  2008cited by this paper
• The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells

  2007cited by this paper
• Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.

  2006cited by this paper
• Interstitial Cells of Cajal (ICC) and Gastrointestinal Stromal Tumor (GIST): facts, speculations, and myths

  2006cited by this paper
• Gastrointestinal Stromal Tumors of the Stomach: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 1765 Cases With Long-term Follow-up

  2005cited by this paper
• Gene Expression in Gastrointestinal Stromal Tumors Is Distinguished by KIT Genotype and Anatomic Site

  2004cited by this paper
• PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

  2003cited by this paper
• Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.

  1998cited by this paper

• MicroRNA expression signature in gastrointestinal stromal tumour & their molecular & histological features

  2024cites this paper
• Análisis de marcadores tumorales en pacientes con tumores estromales gastrointestinales GIST

  2023cites this paper
• Tumor Microenvironment Remodeling in Gastrointestinal Cancer: Role of miRNAs as Biomarkers of Tumor Invasion

  2023influential citation
• miRNAs expression pattern and machine learning models elucidate risk for gastric GIST

  2022cites this paper
• Improved understanding of gastrointestinal stromal tumors biology as a step for developing new diagnostic and therapeutic schemes.

  2021cites this paper
• The Role of lncRNAs in Rare Tumors with a Focus on HOX Transcript Antisense RNA (HOTAIR)

  2021cites this paper
• The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors

  2020cites this paper
• Clinical significance of the molecular heterogeneity of gastrointestinal stromal tumors and related research: A systematic review.

  2020cites this paper
• Signatures of circulating microRNA in four sarcoma subtypes

  2020cites this paper
• Role of non-coding RNAs in pathogenesis of gastrointestinal stromal tumors

  2020cites this paper
• Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors

  2019cites this paper
• Imaging surveillance of gastrointestinal stromal tumour: current recommendation by National Comprehensive Cancer Network and European Society of Medical Oncology-European Reference Network for rare adult solid cancers.

  2019cites this paper