Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation

Aix et al. find that telomere dysfunction is a crucial signal for cardiomyocyte cell-cycle arrest during the postnatal period. After birth, mouse cardiomyocytes undergo telomere shortening. This leads to the appearance of dysfunctional telomeres that activate p21, causing cardiomyocyte cell-cycle withdrawal.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-06-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201510091PMID 27241915PMCID 4896054
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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