The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Alzheimer's & Dementia

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jalz.2014.10.013PMID 25499537PMCID PMC4461564
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

  2014cited by this paper
• Heterozygous TREM2 mutations in frontotemporal dementia.

  2014cited by this paper
• Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention.

  2014cited by this paper
• Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

  2014cited by this paper
• Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia.

  2014cited by this paper
• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

  2014cited by this paper
• TREM2 and neurodegenerative disease.

  2013cited by this paper
• Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.

  2013cited by this paper
• Microglia: Scapegoat, Saboteur, or Something Else?

  2013cited by this paper
• GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.

  2013cited by this paper
• Inflammatory process in Alzheimer's Disease

  2013cited by this paper
• Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

  2013cited by this paper
• TREM2 is associated with the risk of Alzheimer's disease in Spanish population.

  2013cited by this paper
• Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study.

  2013cited by this paper
• Convergent Findings for Abnormalities of the NF-κB Signaling Pathway in Schizophrenia

  2013cited by this paper
• Variant of TREM2 associated with the risk of Alzheimer's disease.

  2013cited by this paper
• Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

  2013cited by this paper
• TREM2 variants in Alzheimer's disease.

  2013cited by this paper
• neurodegeneration : evidence for association of the p . R 47 H variant with frontotemporal dementia and Parkinson ¿ s disease Permalink

  2013cited by this paper
• Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease

  2013cited by this paper
• TREM2 and neurodegenerative disease.

  2013cited by this paper
• TREM2 in Alzheimer’s disease

  2013cited by this paper
• A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples.

  2012cited by this paper
• A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

  2012cited by this paper
• Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature.

  2012cited by this paper
• Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia.

  2012cited by this paper
• Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

  2012cited by this paper
• TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells

  2012cited by this paper
• Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

  2010cited by this paper
• S3‐03‐01: Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia

  2010cited by this paper
• A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

  2009cited by this paper
• Gain in Brain Immunity in the Oldest-Old Differentiates Cognitively Normal from Demented Individuals

  2009cited by this paper
• Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia.

  2009cited by this paper
• Origin and physiological roles of inflammation

  2008cited by this paper
• TREM2 is upregulated in amyloid plaque‐associated microglia in aged APP23 transgenic mice

  2008cited by this paper
• Inflammatory changes parallel the early stages of Alzheimer disease.

  2007cited by this paper
• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  2007cited by this paper
• Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP121

  2006cited by this paper
• Cutting Edge: TREM-2 Attenuates Macrophage Activation1

  2006cited by this paper
• Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

  2005cited by this paper
• Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

  2005cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

  2004cited by this paper
• Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

  2004cited by this paper
• Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.

  2002cited by this paper
• Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

  2002cited by this paper
• Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease.

  1999cited by this paper
• Cholinergic markers in elderly patients with early signs of Alzheimer disease.

  1999cited by this paper
• Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease.

  1998cited by this paper
• The Clinical Dementia Rating scale

  1996cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD).

  1995cited by this paper
• The Clinical Dementia Rating (CDR)

  1993cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

  1991cited by this paper

• Interferon-γ-activated adult human astrocytes induce pyroptosis in neuroblastoma cells

  2026cites this paper
• Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease

  2025cites this paper
• TREM2 in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential

  2025cites this paper
• Roles of TREM2 in Alzheimer’s disease

  2025cites this paper
• Microglial Modulation in Alzheimer's Disease: Central Players in Neuroinflammation and Pathogenesis.

  2025cites this paper
• Interplay between CD33 and TREM2 in Alzheimer's Disease: Potential Mechanistic Insights into Microglial Function in Amyloid Pathology.

  2025cites this paper
• Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy

  2025cites this paper
• TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges.

  2024cites this paper
• TREM2 Alleviates Subarachnoid Hemorrhage-Induced Brain Injury through Attenuating Neuroinflammation and Programmed Cell Death in Vivo and in Vitro.

  2024cites this paper
• Mechanisms of ozone-induced neurotoxicity in the development and progression of dementia: a brief review

  2024cites this paper
• Therapeutic approaches to microglial dysfunction in Alzheimer's disease: Enhancing phagocytosis and metabolic regulation.

  2024cites this paper
• The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish.

  2024cites this paper
• Emerging Microglial Therapies and Targets in Clinical Trial.

  2024cites this paper
• Bibliometric Analysis of TREM2 (2001-2022): Trends, Hotspots and Prospects in Human Disease

  2024cites this paper
• Oxidative stress–mediated neuroinflammation in Alzheimer’s disease

  2024cites this paper
• Six mitophagy-related hub genes as peripheral blood biomarkers of Alzheimer’s disease and their immune cell infiltration correlation

  2023cites this paper
• Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia.

  2023cites this paper
• Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis

  2023cites this paper
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

  2023cites this paper
• Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis

  2023cites this paper
• Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies

  2023cites this paper
• Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

  2023influential citation
• Association of rs2062323 in the TREM1 gene with Alzheimer's disease and cerebrospinal fluid‐soluble TREM2

  2023cites this paper
• Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

  2022cites this paper
• TREM2 dependent and independent functions of microglia in Alzheimer’s disease

  2022cites this paper
• TREM2 R47H variant and risk for Alzheimer’s disease: assessment in a Greek population and updated meta-analysis

  2022cites this paper
• Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages.

  2022cites this paper
• TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

  2022cites this paper
• Single-cell RNA sequencing in atherosclerosis: Mechanism and precision medicine

  2022cites this paper
• TREM2 risk variants are associated with atypical Alzheimer’s disease

  2022cites this paper
• TREM2 coding variants in Slovak Alzheimer's disease patients.

  2022cites this paper
• Research Progress on the Role of Microglia Membrane Proteins or Receptors in Neuroinflammation and Degeneration

  2022cites this paper
• Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease: Current Evidence and Future Perspectives

  2021cites this paper
• AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

  2021cites this paper
• Inflammatory Cascade in Alzheimer’s Disease Pathogenesis: A Review of Experimental Findings

  2021cites this paper
• Reduced TREM2 activation in microglia of patients with Alzheimer's disease

  2021cites this paper
• Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

  2021cites this paper
• Multi-scale modeling for systematically understanding the key roles of microglia in AD development

  2021cites this paper
• Neuroprotection through G-CSF: recent advances and future viewpoints

  2021cites this paper
• The most prevalent rare coding variants of TREM2 conferring risk of Alzheimer's disease: A systematic review and meta-analysis

  2021cites this paper
• Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

  2021cites this paper
• AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

  2020cites this paper
• Differential role of triggering receptors expressed on myeloid cells 2 R47H in 3 neurodegenerative diseases based on a systematic review and meta-analysis

  2020cites this paper
• Blood and cerebrospinal fluid biomarkers for Alzheimer’s disease

  2020cites this paper
• Characterization and Therapeutic Manipulation of Glioblastoma-Associated Microglia, Macrophages, and Cytokines to Improve Prognosis

  2020cites this paper
• Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework

  2020cites this paper
• Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease

  2020cites this paper
• Glia-Driven Neuroinflammation and Systemic Inflammation in Alzheimer’s Disease

  2020cites this paper
• Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

  2019cites this paper
• TREM2 Variants and Neurodegenerative Diseases: A Systematic Review and Meta-Analysis

  2019cites this paper
• Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress.

  2019cites this paper
• Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.

  2019cites this paper
• Full genome analysis of microglial activation : ramifications of TREM2

  2019cites this paper
• Analysis of Cerebrospinal Fluid Soluble TREM2 and Polymorphisms in Sporadic Parkinson’s Disease in a Chinese Population

  2019cites this paper
• Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

  2019cites this paper
• PRECLINICAL TARGETING OF TREM2 FOR THE TREATMENT OF ALZHEIMER'S DISEASE-TYPE PATHOLOGY IN A TRANSGENIC MOUSE MODEL

  2019cites this paper
• Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

  2019cites this paper
• TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

  2019cites this paper
• Systematically understanding the key roles of microglia in AD development

  2019cites this paper
• Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease

  2019cites this paper
• High TREM2 expression correlates with poor prognosis in gastric cancer.

  2018cites this paper
• Precision pharmacology for Alzheimer's disease.

  2018cites this paper
• New insights into the role of TREM2 in Alzheimer’s disease

  2018cites this paper
• Current state of Alzheimer’s fluid biomarkers

  2018cites this paper
• Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

  2018influential citation
• Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

  2018cites this paper
• The p.R47H Variant of TREM2 Gene is Associated With Late-onset Alzheimer Disease in Colombian Population

  2018cites this paper
• The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.

  2018cites this paper
• TREM2 regulates innate immunity in Alzheimer’s disease

  2018cites this paper
• Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

  2018cites this paper
• The role of TREM2 in Alzheimer’s disease and other neurodegenerative diseases

  2018cites this paper
• Early and Late CNS Inflammation in Alzheimer's Disease: Two Extremes of a Continuum?

  2017cites this paper
• Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

  2017cites this paper
• Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer’s disease in a Chinese Han population

  2017influential citation
• N-3 Polyunsaturated Fatty Acids and Neuroinflammation in Alzheimer's Disease

  2017cites this paper
• ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after histidine 157

  2017cites this paper
• Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review.

  2017cites this paper
• TREM2 in Neurodegenerative Diseases

  2017influential citation
• Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

  2017cites this paper
• Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

  2017cites this paper
• Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

  2016cites this paper
• Upregulation of PRDM5 Is Associated with Astrocyte Proliferation and Neuronal Apoptosis Caused by Lipopolysaccharide

  2016cites this paper
• Genetic, transcriptome, proteomic and epidemiological evidence for blood brain barrier disruption and polymicrobial brain invasion as determinant factors in Alzheimer’s disease

  2016cites this paper
• Protective effect of paeoniflorin on inflammation and apoptosis in the cerebral cortex of a transgenic mouse model of Alzheimer's disease.

  2016cites this paper
• TREMs in Alzheimer's disease: Genetic and clinical investigations.

  2016cites this paper
• Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

  2016cites this paper
• The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2

  2016cites this paper
• TREM2 variants and risk of Alzheimer’s disease: a meta-analysis

  2015cites this paper
• Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

  2015cites this paper
• More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

  2015influential citation