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Roadblocks in the Path of iPSC to the Clinic

E. Garreta,S. Sanchez,J. Lajara,N. Montserrat,J. Belmonte

Published 2018 in Current Transplantation Reports

ABSTRACT

Purpose of ReviewThe goal of this paper is to highlight the major challenges in the translation of human pluripotent stem cells into a clinical setting.Recent FindingsInnate features from human induced pluripotent stem cells (hiPSCs) positioned these patient-specific cells as an unprecedented cell source for regenerative medicine applications. Immunogenicity of differentiated iPSCs requires more research towards the definition of common criteria for the evaluation of innate and host immune responses as well as in the generation of standardized protocols for iPSC generation and differentiation. The coming years will resolve ongoing clinical trials using both human embryonic stem cells (hESCs) and hiPSCs providing exciting information for the optimization of potential clinical applications of stem cell therapies.SummaryRapid advances in the field of iPSCs generated high expectations in the field of regenerative medicine. Understanding therapeutic applications of iPSCs certainly needs further investigation on autologous/allogenic iPSC transplantation.

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