Endocytic Transport of Polyplex and Lipoplex siRNA Vectors in HeLa Cells

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Pharmaceutical Research

• Publication date

  2016-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11095-016-2022-1PMID 27585903
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways

  2014influential reference
• Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

  2013cited by this paper
• Uptake mechanisms of non-viral gene delivery.

  2012influential reference
• siRNA Therapeutic Design: Tools and Challenges

  2012cited by this paper
• Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides.

  2012cited by this paper
• Polyplexes traffic through caveolae to the Golgi and endoplasmic reticulum en route to the nucleus.

  2012influential reference
• New links between vesicle coats and Rab-mediated vesicle targeting.

  2011cited by this paper
• Endosome maturation

  2011cited by this paper
• Flotillin-dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes.

  2011cited by this paper
• Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.

  2011cited by this paper
• Unconventional internalization mechanisms underlying functional delivery of antisense oligonucleotides via cationic lipoplexes and polyplexes.

  2011influential reference
• Current prospects for RNA interference-based therapies

  2011cited by this paper
• Chemical vectors for gene delivery: uptake and intracellular trafficking.

  2010cited by this paper
• Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.

  2010cited by this paper
• Poly(glycoamidoamine) vehicles promote pDNA uptake through multiple routes and efficient gene expression via caveolae-mediated endocytosis.

  2010cited by this paper
• Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

  2010cited by this paper
• Lipid‐based nanotherapeutics for siRNA delivery

  2010cited by this paper
• Endocytosis unplugged: multiple ways to enter the cell

  2010influential reference
• The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls.

  2010cited by this paper
• Peptide- and polymer-based delivery of therapeutic RNA

  2010cited by this paper
• Defining Macropinocytosis

  2009cited by this paper
• Nonviral methods for siRNA delivery.

  2009cited by this paper
• A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery

  2009cited by this paper
• Mechanisms of endocytosis.

  2009influential reference
• Ethylendiamine core PAMAM dendrimers/siRNA complexes as in vitro silencing agents.

  2009cited by this paper
• Pathways and mechanisms of endocytic recycling

  2009cited by this paper
• Elucidation of Design Criteria for siRNA Delivery in Mammalian Cells Using Polyethylenimine

  2009cited by this paper
• Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?

  2008cited by this paper
• Toward Development of Artificial Viruses for Gene Therapy: A Comparative Evaluation of Viral and Non‐viral Transfection

  2008cited by this paper
• Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.

  2008influential reference
• Shaping cups into phagosomes and macropinosomes

  2008cited by this paper
• Rational design of cationic cyclooligosaccharides as efficient gene delivery systems.

  2008cited by this paper
• A Fast Thresholded Landweber Algorithm for Wavelet-Regularized Multidimensional Deconvolution

  2008cited by this paper
• Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

  2007cited by this paper
• Internalization and Trafficking of Cell Surface Proteoglycans and Proteoglycan‐Binding Ligands

  2007cited by this paper
• Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery.

  2007cited by this paper
• Cellular Uptake of Cationic Polymer-DNA Complexes Via Caveolae Plays a Pivotal Role in Gene Transfection in COS-7 Cells

  2007cited by this paper
• INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES

  2006cited by this paper
• Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

  2006cited by this paper
• The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type.

  2006cited by this paper
• Delivery of RNA Interference

  2006cited by this paper
• Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin.

  2006cited by this paper
• Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery.

  2006cited by this paper
• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery

  2006influential reference
• Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes.

  2005cited by this paper
• Cationic TAT peptide transduction domain enters cells by macropinocytosis.

  2005cited by this paper
• Purified Argonaute2 and an siRNA form recombinant human RISC

  2005influential reference
• In vivo activity of nuclease-resistant siRNAs.

  2004cited by this paper
• Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

  2004cited by this paper
• Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.

  2004cited by this paper
• Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis.

  2004cited by this paper
• Caveolae/raft-dependent endocytosis

  2003cited by this paper
• Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane*

  2003cited by this paper
• Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

  2001cited by this paper
• Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications.

  2001cited by this paper
• Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells.

  1999cited by this paper
• Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum

  1998cited by this paper
• Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery

  1997cited by this paper
• Macropinocytosis.

  1995cited by this paper
• Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

  1993cited by this paper
• Analysis of Variance with Just Summary Statistics as Input

  1992cited by this paper
• Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle.

  1991cited by this paper
• Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines

  1991cited by this paper
• Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

  1987cited by this paper

• Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles

  2025cites this paper
• Designing Nanomedicines for Breast Cancer Therapy

  2023influential citation
• Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

  2023cites this paper
• Efficiency and Safety of Dextran-PAMAM/siMMP-9 Complexes for Decreasing Matrix Metalloproteinase-9 Expression and Promoting Wound Healing in Diabetic Rats.

  2022cites this paper
• Polycation-Mediated Transfection: Mechanisms of Internalization and Intracellular Trafficking.

  2021cites this paper
• Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy

  2021cites this paper
• Physical and mechanical cues affecting biomaterial-mediated plasmid DNA delivery: insights into non-viral delivery systems

  2021cites this paper
• Polymeric Delivery of Therapeutic Nucleic Acids.

  2021cites this paper
• Cationic lipids for gene delivery: many players, one goal.

  2020cites this paper
• Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system.

  2020cites this paper
• Endocytosis Controls siRNA Efficiency: Implications for siRNA Delivery Vehicle Design and Cell-Specific Targeting

  2019cites this paper
• Impact of physicochemical properties of DNA/PEI complexes on transient transfection of mammalian cells.

  2019cites this paper
• A progressively targeted gene delivery system with a pH triggered surface charge-switching ability to drive angiogenesis in vivo.

  2019cites this paper
• A "self-accelerating endosomal escape" siRNA delivery nanosystem for significantly suppressing hyperplasia via blocking the ERK2 pathway.

  2019cites this paper
• Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers

  2019cites this paper
• Molecular Weight-Dependent Activity of Aminated Poly(α)glutamates as siRNA Nanocarriers

  2018cites this paper
• Theranostic Niosomes for Efficient siRNA/MicroRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells.

  2018cites this paper
• From organelle over cell to tissue: Development of fluorescence-based methods to monitor the fate of model transporting structures

  2018cites this paper
• Regulation of the PP2AC, PP4C, PP6C and alpha4 signalling axis in the myocardium : roles in calcium homeostasis and hypertrophy

  2017cites this paper
• Transmembrane Pathways and Mechanisms of Rod-like Paclitaxel Nanocrystals through MDCK Polarized Monolayer.

  2017cites this paper
• Enhanced cellular uptake and gene silencing activity of siRNA using temperature-responsive polymer-modified liposome.

  2017cites this paper
• Evaluation of Small Interfering RNA Delivery into Cells by Reverse Transfection in Suspension with Cationic Liposomes

  2017cites this paper
• Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo.

  2017cites this paper