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Histamine and Breast Cancer: A New Role for a Well Known Amine

G. Cricco,N. Mohamad,M. Sáez,E. Valli,E. Rivera,G. Martín

Published 2011 in Unknown venue

ABSTRACT

Metastases are the most devastating aspect of cancer since most deaths from cancer are related to them. The ability of tumors to invade the neighboring extracellular matrix, which is primarily accompanied by augmented matrix metalloproteinases (MMPs) production and cell migration, is critical for metastases. After surgical removal of primary breast tumors, malignant cells may still remain and radiotherapy is an efficient modality to reduce the risk of local recurrence. However, proliferative, invasive, and metastatic capacities can be increased in the surviving tumor cells of irradiated breast and other neoplasias (Baluna et al, 2006; Tsukamoto et al, 2007; Tsutsumi et al, 2009). To improve the efficacy of radiotherapy, this phenomenon must be further studied to elaborate therapeutic modalities to prevent radiation enhancement of cancer cell invasion. Histamine is an endogenous biogenic amine extensively distributed throughout the organism which exerts multiple functions in physiologic and pathophysiological processes by stimulation of four G-protein coupled receptors (H1, H2, H3 and H4 histamine receptors) with different tissue expression patterns and functions. It is well known that diverse tumoral tissues and cell lines express the different histamine receptors through which histamine brings about its effects on cell proliferation, differentiation, survival and death. A great deal of evidence shows a relevant role of histamine in tumor progression, however controversial results are published depending on the cell type and the histamine receptor subtype that is activated (Blaya et al, 2010; Francis et al, 2009; Parsons & Ganellin, 2006; Soule et al, 2010). It has also been determined that numerous tumour tissues and cell lines express L-histidine decarboxylase, the histamine-synthesizing enzyme, and contain high levels of endogenous histamine which released to the extracellular media may exert its effects via a paracrine or autocrine regulation (Falus et al, 2001; Pos et al, 2004; Rivera et al, 2000). Additionally some effects on tumor growth may be mediated by histamine regulation of angiogenesis and immunity (Lazar-Molnar et al, 2002; Tomita et al, 2003). Our research team has demonstrated the expression of histamine membrane receptors and their association to different signalling pathways in breast cancer biopsies and a large number of transformed cell lines, being our works the first ones to report the presence of H3

PUBLICATION RECORD

  • Publication year

    2011

  • Venue

    Unknown venue

  • Publication date

    2011-11-30

  • Fields of study

    Biology, Medicine

  • Identifiers
    DOI 10.5772/20633
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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