Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Biochemical Society Transactions

• Publication date

  1995-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BST0230929PMID 8654869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

  1995cited by this paper
• Altering mice by homologous recombination using embryonic stem cells.

  1994cited by this paper
• Molecular mechanisms of action of steroid/thyroid receptor superfamily members.

  1994cited by this paper
• Hormone-nuclear receptor interactions in health and disease. The oestrogen receptor.

  1994cited by this paper
• Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast‐like cell lines

  1994cited by this paper
• Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

  1994cited by this paper
• Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.

  1994cited by this paper
• Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bones.

  1994cited by this paper
• Insights from the study of animals lacking functional estrogen receptor.

  1994cited by this paper
• Ovarian follicle atresia: a hormonally controlled apoptotic process.

  1994cited by this paper
• Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

  1993cited by this paper
• Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development.

  1993cited by this paper
• Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists.

  1993cited by this paper
• Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis.

  1993cited by this paper
• Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

  1993cited by this paper
• Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

  1992cited by this paper
• Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes.

  1992cited by this paper
• Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.

  1992cited by this paper
• Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene.

  1991cited by this paper
• Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation.

  1991cited by this paper
• The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue.

  1991cited by this paper
• Molecular cloning, sequence analyses, and expression of complementary DNA encoding murine progesterone receptor.

  1991cited by this paper
• Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen.

  1990cited by this paper
• Differential effects of ovarian steroids and triphenylethylene compounds on macromolecular uptake and thymidine incorporation in the mouse uterus.

  1990cited by this paper
• Estrogen regulates the synthesis of epidermal growth factor in mouse uterine epithelial cells.

  1990cited by this paper
• Lactotransferrin gene expression in the mouse uterus and mammary gland.

  1989cited by this paper
• The steroid and thyroid hormone receptor superfamily.

  1988cited by this paper
• Evidence of estrogen receptors in normal human osteoblast-like cells.

  1988cited by this paper
• Influence of estrogens on mouse uterine epidermal growth factor precursor protein and messenger ribonucleic acid.

  1988cited by this paper
• Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells.

  1988cited by this paper
• Estradiol-stimulated proteolytic cleavage of the estrogen receptor in mouse uterus.

  1988cited by this paper
• Genomic organization of the human oestrogen receptor gene.

  1988cited by this paper
• Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions.

  1987cited by this paper
• Structural organization and expression of the mouse estrogen receptor.

  1987cited by this paper
• Estrogenic regulation of growth and polypeptide growth factor secretion in human breast carcinoma.

  1987cited by this paper
• Diethylstilbestrol metabolites and analogs. Biochemical probes for differential stimulation of uterine estrogen responses.

  1985cited by this paper
• Regulation of epidermal growth factor receptor by estrogen.

  1985cited by this paper
• Estrogen action in the mouse uterus: characterization of the cytosol and nuclear receptor systems.

  1979cited by this paper

• Novel estrogen receptor-α gene inactivating missense variant in a woman: Therapeutic challenge and long-term follow-up data.

  2025cites this paper
• Estrogens: Two nuclear receptors, multiple possibilities.

  2022cites this paper
• The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health.

  2020cites this paper
• Ovarian Hormones

  2020cites this paper
• The Aqueous Extract of Dacryodes edulis (Burseraceae) Leaves Inhibits Cell Proliferation Induced by Estradiol on the Uterus and Vagina of Ovariectomized Female Wistar Rats

  2020cites this paper
• ERα in the Control of Mitochondrial Function and Metabolic Health.

  2020cites this paper
• Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation

  2018cites this paper
• The impact of ERα action on muscle metabolism and insulin sensitivity – Strong enough for a man, made for a woman

  2018cites this paper
• Rodent Models of Non-classical Progesterone Action Regulating Ovulation

  2017cites this paper
• The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity.

  2017cites this paper
• New concepts of the central control of reproduction, integrating influence of stress, metabolic state, and season.

  2016cites this paper
• Kisspeptins, Estrogens and Male Fertility.

  2016cites this paper
• What have we learned about GPER function in physiology and disease from knockout mice?

  2015cites this paper
• Oestradiol‐Induced Synapse Formation in the Female Hippocampus: Roles of Oestrogen Receptor Subtypes

  2014cites this paper
• Cross-talk between metabolism and reproduction : the role of POMC and SF 1 neurons

  2013cites this paper
• Neuroendocrine Control of Reproduction

  2012cites this paper
• Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons

  2012cites this paper
• Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model.

  2012cites this paper
• Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.

  2012cites this paper
• Brain Estrogens and Metabolism

  2011cites this paper
• Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}.

  2010cites this paper
• Pathologic characteristics of ovarian hemorrhagic polycyst in estrogen receptor-alpha (ERα) knockout mice and roles of erα in hemorrhagic polycyst

  2010cites this paper
• Estradiol-17beta-responsive A1 and A2 noradrenergic cells of the brain stem project to the bed nucleus of the stria terminalis in the ewe brain: a possible route for regulation of gonadotropin releasing hormone cells.

  2010cites this paper
• Response of adult mouse uterus to early disruption of estrogen receptor-alpha signaling is influenced by Krüppel-like factor 9.

  2010cites this paper
• Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii.

  2010cites this paper
• Impaired Estrogen Feedback and Infertility in Female Mice with Pituitary-Specific Deletion of Estrogen Receptor Alpha (ESR1)1

  2009cites this paper
• Differential estrogenic 17beta-hydroxysteroid dehydrogenase activity and type 12 17beta-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes.

  2009cites this paper
• Embryology of the uterus

  2008cites this paper
• The characteristic change in the distribution of S-100 immunoreactive folliculostellate cells in rat anterior pituitary upon long-term estrogen treatment is prevented by concomitant progesterone treatment

  2008cites this paper
• Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus.

  2008cites this paper
• THE ROLE OF ESTROGEN IN THE INDUCTION AND MODULATION OF SYSTEMIC LUPUS ERYTHROMATOSUS (SLE)

  2006cites this paper
• Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus.

  2006influential citation
• Estrogen and folliculogenesis: is one necessary for the other?

  2005cites this paper
• Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy

  2005cites this paper
• Involvement of estrogen receptor beta in ovarian carcinogenesis.

  2004cites this paper
• Involvement of Estrogen Receptor β in Ovarian Carcinogenesis

  2004cites this paper
• The Relative Contribution Exerted by AF-1 and AF-2 Transactivation Functions in Estrogen Receptor α Transcriptional Activity Depends upon the Differentiation Stage of the Cell*

  2004cites this paper
• Molecular basis of pituitary development and cytogenesis.

  2004cites this paper
• Fibronectin and type IV collagen activate ERα AF-1 by c-Src pathway: effect on breast cancer cell motility

  2004cites this paper
• Estrogen receptor knockout mice as a model for endocrine research.

  2004cites this paper
• Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.

  2003cites this paper
• Estrogen receptor‐α is required for estrogen‐induced μ‐opioid receptor internalization

  2003cites this paper
• Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse.

  2003cites this paper
• Suppression of Estrogen Receptor-mediated Transcription and Cell Growth by Interaction with TR2 Orphan Receptor*

  2002cites this paper
• Hypothalamische und hypophysäre Erkrankungen.

  2001cites this paper
• Steroid receptor knockout models: phenotypes and responses illustrate interactions between receptor signaling pathways in vivo.

  2000cites this paper
• Progesterone action and responses in the alphaERKO mouse.

  2000cites this paper
• [Preclinical evaluation of aromatase inhibitors antitumor activity].

  2000cites this paper
• Progesterone action and responses in the αERKO mouse

  2000cites this paper
• Sex with knockout models: behavioral studies of estrogen receptor alpha.

  1999cites this paper
• Expression of estrogen receptor-beta protein in rodent ovary.

  1999cites this paper
• Sex with knockout models: behavioral studies of estrogen receptor α

  1999cites this paper
• Expression of Estrogen Receptor-β Protein in Rodent Ovary.

  1999cites this paper
• Ovary-independent estrogen receptor expression in neonatal porcine endometrium.

  1998cites this paper
• Role of Cytokines in the Pregnant Uterus of Interstitial Implanting Species

  1998cites this paper
• Generation and reproductive phenotypes of mice lacking estrogen receptor beta.

  1998cites this paper
• Sex differences in the activational effect of ERalpha on spatial learning.

  1998cites this paper
• The cytogenesis and pathogenesis of pituitary adenomas.

  1998cites this paper
• Sex Differences in the Activational Effect of ERα on Spatial Learning

  1998cites this paper
• An essential role for C/EBPbeta in female reproduction.

  1997cites this paper
• Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects.

  1997cites this paper
• Developmental and physiological effects of estrogen receptor gene disruption in mice.

  1997cites this paper
• Two separate mechanisms for ligand-independent activation of the estrogen receptor.

  1997cites this paper
• Brca1 is expressed independently of hormonal stimulation in the mouse ovary.

  1997cites this paper
• The use of genetic "knockout" mice in behavioral endocrinology research.

  1997cites this paper
• Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse.

  1997cites this paper
• Interaction between estradiol and growth factors in the regulation of specific gene expression in MCF-7 human breast cancer cells.

  1997cites this paper
• The Effects of Estrogen Receptor Gene Disruption on Bone

  1997cites this paper
• Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse.

  1997cites this paper