Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Allergy and Clinical Immunology

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jaci.2012.07.032PMID 22944483PMCID PMC3652680
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.

  2012cited by this paper
• Targeted therapies: Pim kinase inhibition and chemoresistance

  2010cited by this paper
• IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

  2010cited by this paper
• A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma

  2010cited by this paper
• PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

  2010cited by this paper
• Complement-mediated regulation of the interleukin 17A axis is a central genetic determinant of the severity of experimental allergic asthma

  2010cited by this paper
• Oral peanut immunotherapy in children with peanut anaphylaxis.

  2010cited by this paper
• Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.

  2010cited by this paper
• A T(h)17-polarized cell population that has infiltrated the lung requires cells that convert to IFN-{gamma} production in order to induce airway hyperresponsiveness.

  2010cited by this paper
• Complement-mediated Regulation Of The IL-17A Axis Is A Central Genetic Determinant Of The Severity Of Experimental Allergic Asthma

  2010cited by this paper
• Faculty Opinions recommendation of IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.

  2010cited by this paper
• Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21

  2009cited by this paper
• The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA31

  2009cited by this paper
• Inhibition of T cell function in vitro and in vivo using small molecule antagonists of PIM kinases (35.33)

  2009cited by this paper
• RUNX proteins in transcription factor networks that regulate T-cell lineage choice

  2009cited by this paper
• Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT.

  2009cited by this paper
• Corticosteroids enhance CD8+ T cell-mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1.

  2008cited by this paper
• Essential role of Notch signaling in effector memory CD8+ T cell–mediated airway hyperresponsiveness and inflammation

  2008cited by this paper
• Th17 cells in human disease

  2008cited by this paper
• Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

  2007cited by this paper
• IL-13 is essential to the late-phase response in allergic rhinitis.

  2006cited by this paper
• The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8+ T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness1

  2006cited by this paper
• Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

  2006cited by this paper
• Expression of human pim family genes is selectively up‐regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation

  2005cited by this paper
• The Pim kinases control rapamycin-resistant T cell survival and activation

  2005cited by this paper
• The serine/threonine kinase Pim-1.

  2005cited by this paper
• Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease.

  2005cited by this paper
• Interleukin-17 family members and inflammation.

  2004cited by this paper
• Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia.

  2004cited by this paper
• IL-5 and Granulocyte-Macrophage Colony-Stimulating Factor Activate STAT3 and STAT5 and Promote Pim-1 and Cyclin D3 Protein Expression in Human Eosinophils1

  2004cited by this paper
• The Runx1 Transcription Factor Inhibits the Differentiation of Naive CD4+ T Cells into the Th2 Lineage by Repressing GATA3 Expression

  2003cited by this paper
• Cutting Edge: Transcriptional Activity of NFATc1 Is Enhanced by the Pim-1 Kinase1

  2002cited by this paper
• T lymphocytes in food allergy: Overview of an intricate network of circulating and 
organ‐resident cells

  2002cited by this paper
• Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

  2002cited by this paper
• Asthma and atopy – a total genome scan for susceptibility genes

  2002cited by this paper
• Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity1

  2001cited by this paper
• Temporal association between airway hyperresponsiveness and airway eosinophilia in ovalbumin-sensitized mice.

  2001cited by this paper
• A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses.

  2000cited by this paper
• A novel transcription factor, T-bet, directs Th1 lineage commitment.

  2000cited by this paper
• Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.

  2000cited by this paper
• Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

  1999cited by this paper
• Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells.

  1999cited by this paper
• The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1.

  1998cited by this paper
• Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism.

  1998cited by this paper
• The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.

  1997cited by this paper
• Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.

  1997cited by this paper
• Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype

  1996cited by this paper
• AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

  1996cited by this paper
• pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1.

  1996cited by this paper
• Identification and chromosomal mapping of a third mouse runt-like locus.

  1995cited by this paper
• AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

  1994cited by this paper
• Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines.

  1988cited by this paper

• New approaches in childhood IgE-mediated food allergy treatment

  2025cites this paper
• PIM1 orchestrates sepsis-associated inflammatory imbalance in CD4+ T cell subsets via cholesterol metabolism

  2025cites this paper
• Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity

  2025cites this paper
• PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target

  2024cites this paper
• Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation

  2024cites this paper
• Gene Editing in Allergic Diseases: Identification of Novel Pathways and Impact of Deleting Allergen Genes.

  2024cites this paper
• Pim1 inactivating induces RUNX3 upregulation that improves/alleviates airway inflammation and mucus hypersecretion in vitro and in vivo

  2024cites this paper
• Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing

  2024cites this paper
• The role of Pim-1 kinases in inflammatory signaling pathways

  2024cites this paper
• PIM1 inhibitor SMI-4a attenuated concanavalin A-induced acute hepatitis through suppressing inflammatory responses

  2023cites this paper
• Long-term changes of Th17 and regulatory T cells in peripheral blood of dogs with spinal cord injury after intervertebral disc herniation

  2023cites this paper
• Bifidobacterium longum subsp. infantis B6MNI Alleviates Collagen-Induced Arthritis in Rats via Regulating 5-HIAA and Pim-1/JAK/STAT3 Inflammation Pathways.

  2023cites this paper
• Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance

  2021cites this paper
• Runx Transcription Factors in T Cells—What Is Beyond Thymic Development?

  2021cites this paper
• The role of Pim kinase in immunomodulation.

  2020cites this paper
• Discovery of SARxxxx92, a pan-PIM kinase Inhibitor, efficacious in a KG1 tumor model.

  2020cites this paper
• Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III.

  2019cites this paper
• Pim‐1 as a Therapeutic Target in Lupus Nephritis

  2019cites this paper
• University of Groningen Pim 1 kinase : a double-edged sword

  2018cites this paper
• Accelerating annotation of articles via automated approaches: evaluation of the neXtA5 curation-support tool by neXtProt

  2018cites this paper
• Pim-1 kinase regulates CD4+T cell differentiation

  2017influential citation
• Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

  2017cites this paper
• Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II.

  2017cites this paper
• Spectrum of T‐lymphocyte activities regulating allergic lung inflammation

  2017cites this paper
• Current advances of murine models for food allergy.

  2016cites this paper
• Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy

  2016cites this paper
• Forkhead box protein 3 demethylation is associated with tolerance induction in peanut‐induced intestinal allergy

  2016cites this paper
• Inactivation of RUNX3/p46 Promotes Cutaneous T-Cell Lymphoma.

  2016cites this paper
• Combined blockade of the histamine H1 and H4 receptor suppresses peanut‐induced intestinal anaphylaxis by regulating dendritic cell function

  2016cites this paper
• The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

  2015cites this paper
• Pim1 kinase: a double-edged sword: The divergent roles of a survival kinase in environment-airway epithelium interaction

  2015cites this paper
• Pim 1 kinase activity preserves airway epithelial integrity upon 1 house dust mite exposure 2

  2015cites this paper
• Gastrointestinal Immune Response to the Shrimp Allergen Tropomyosin: Histological and Immunological Analysis in an Animal Model of Shrimp Tropomyosin Hypersensitivity

  2015cites this paper
• Targeting antibody secreting B cells as a novel therapeutic approach to treat allergic diseases

  2014cites this paper
• Targeting Pim1 kinase in the treatment of peanut allergy

  2014cites this paper
• PIM KINASE INHIBITION: SINGLE AGENT AND COMBINATION APPROACHES IN B-CELL LYMPHOMA

  2013cites this paper
• Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012.

  2013cites this paper
• The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.

  2013cites this paper