DNA Damage Tolerance Pathway Choice Through Uls1 Modulation of Srs2 SUMOylation in Saccharomyces cerevisiae

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Genetics

• Publication date

  2017-03-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1534/genetics.116.196568PMID 28341648PMCID PMC5419492
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multifunctional roles of Saccharomyces cerevisiae Srs2 protein in replication, recombination and repair.

  2016influential reference
• Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction*

  2016cited by this paper
• Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication

  2015cited by this paper
• Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress.

  2014cited by this paper
• Shared Genetic Pathways Contribute to the Tolerance of Endogenous and Low-Dose Exogenous DNA Damage in Yeast

  2014influential reference
• Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability

  2014cited by this paper
• Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

  2014cited by this paper
• Strand invasion by HLTF as a mechanism for template switch in fork rescue

  2013cited by this paper
• The Preference for Error-Free or Error-Prone Postreplication Repair in Saccharomyces cerevisiae Exposed to Low-Dose Methyl Methanesulfonate Is Cell Cycle Dependent

  2013cited by this paper
• Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

  2013influential reference
• Putative antirecombinase Srs2 DNA helicase promotes noncrossover homologous recombination avoiding loss of heterozygosity

  2013cited by this paper
• Physical and Genetic Interactions Between Uls1 and the Slx5–Slx8 SUMO-Targeted Ubiquitin Ligase

  2013cited by this paper
• End‐joining inhibition at telomeres requires the translocase and polySUMO‐dependent ubiquitin ligase Uls1

  2013cited by this paper
• Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.

  2013cited by this paper
• Causes and consequences of replication stress

  2013cited by this paper
• Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

  2013cited by this paper
• Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

  2013cited by this paper
• Competition, collaboration and coordination – determining how cells bypass DNA damage

  2012cited by this paper
• A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA

  2012cited by this paper
• Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

  2012cited by this paper
• Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation

  2012influential reference
• The Swi2–Snf2-like protein Uls1 is involved in replication stress response

  2011cited by this paper
• Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors

  2011cited by this paper
• Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions.

  2011cited by this paper
• Elg1, the major subunit of an alternative RFC complex, interacts with SUMO-processing proteins

  2011cited by this paper
• Degringolade, a SUMO‐targeted ubiquitin ligase, inhibits Hairy/Groucho‐mediated repression

  2011cited by this paper
• Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

  2010cited by this paper
• Multiple Rad5 activities mediate sister chromatid recombination to bypass DNA damage at stalled replication forks.

  2010cited by this paper
• Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance.

  2010influential reference
• Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair

  2010cited by this paper
• Srs2 Plays a Critical Role in Reversible G2 Arrest upon Chronic and Low Doses of UV Irradiation via Two Distinct Homologous Recombination-Dependent Mechanisms in Postreplication Repair-Deficient Cells

  2010cited by this paper
• Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation

  2010cited by this paper
• SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.

  2010cited by this paper
• Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3

  2010cited by this paper
• Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair

  2009cited by this paper
• Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

  2008cited by this paper
• Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA

  2008cited by this paper
• Probabilistic image registration and anomaly detection by nonlinear warping

  2008cited by this paper
• SUMOylation regulates Rad18-mediated template switch

  2008cited by this paper
• SUMO modification of PCNA is controlled by DNA

  2008cited by this paper
• Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

  2007cited by this paper
• Ubiquitin-dependent Proteolytic Control of SUMO Conjugates*

  2007cited by this paper
• PCNA, the maestro of the replication fork.

  2007cited by this paper
• Sgs1 Regulates Gene Conversion Tract Lengths and Crossovers Independently of Its Helicase Activity

  2006cited by this paper
• Yeast Rmi1/Nce4 Controls Genome Stability as a Subunit of the Sgs1-Top3 Complex

  2005cited by this paper
• Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

  2005cited by this paper
• Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

  2005cited by this paper
• SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

  2005cited by this paper
• The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments

  2003cited by this paper
• Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.

  2003cited by this paper
• DNA helicase Srs2 disrupts the Rad51 presynaptic filament

  2003cited by this paper
• DNA helicase Srs 2 disrupts the Rad 51 presynaptic filament

  2003cited by this paper
• SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002influential reference
• Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

  2002cited by this paper
• Deletion of the SRS2 gene suppresses elevated recombination and DNA damage sensitivity in rad5 and rad18 mutants of Saccharomyces cerevisiae.

  2001cited by this paper
• Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae.

  2001cited by this paper
• Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.

  2001influential reference
• Two RING finger proteins mediate cooperation between ubiquitin‐conjugating enzymes in DNA repair

  2000cited by this paper
• PCNA connects DNA replication to epigenetic inheritance in yeast

  2000influential reference
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• Homologous recombination is required for the viability of rad27 mutants.

  1998cited by this paper
• The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase

  1994cited by this paper

• The role of SUMOylation in biomolecular condensate dynamics and protein localization

  2024cites this paper
• Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases

  2023cites this paper
• Rrp1, Rrp2 and Uls1 - Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance.

  2022cites this paper
• SUMO is a pervasive regulator of meiosis

  2021cites this paper
• SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability

  2021cites this paper
• Access to PCNA by Srs2 and Elg1 controls the choice between alternative repair pathways in yeast

  2020cites this paper
• Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae

  2020cites this paper
• Deletion of ULS1 confers damage tolerance in sgs1 mutants through a Top3-dependent D-loop mediated fork restart pathway.

  2019cites this paper
• Intricate SUMO-based control of the homologous recombination machinery

  2019cites this paper
• Delineation of the SUMO-Modified Proteome Reveals Regulatory Functions Throughout Meiosis

  2019cites this paper