Multimodal imaging of mild traumatic brain injury and persistent postconcussion syndrome

Persistent postconcussion syndrome (PCS) occurs in around 5–10% of individuals after mild traumatic brain injury (mTBI), but research into the underlying biology of these ongoing symptoms is limited and inconsistent. One reason for this could be the heterogeneity inherent to mTBI, with individualized injury mechanisms and psychological factors. A multimodal imaging study may be able to characterize the injury better.

• Publication year

  2014

• Venue

  Brain and Behavior

• Publication date

  2014-12-02

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/brb3.292PMID 25722949PMCID 4321394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proposed declassification of disease categories related to sexual orientation in the International Statistical Classification of Diseases and Related Health Problems (ICD-11)

  2014cited by this paper
• Monitoring long-term effects of mild traumatic brain injury with magnetic resonance spectroscopy: a pilot study

  2013influential reference
• Long-term effects of mild traumatic brain injury on cognitive performance

  2013influential reference
• Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

  2013cited by this paper
• Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers

  2013cited by this paper
• Salience network integrity predicts default mode network function after traumatic brain injury

  2012cited by this paper
• Abnormal whole-brain functional networks in homogeneous acute mild traumatic brain injury

  2012influential reference
• A functional MRI study of multimodal selective attention following mild traumatic brain injury

  2012influential reference
• A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury

  2012influential reference
• Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction☆

  2012influential reference
• Working memory in patients with mild traumatic brain injury: functional MR imaging analysis.

  2012influential reference
• Alteration of brain default network in subacute phase of injury in concussed individuals: Resting-state fMRI study

  2012influential reference
• Biomarkers of increased diffusion anisotropy in semi-acute mild traumatic brain injury: a longitudinal perspective.

  2012cited by this paper
• Voxel- and atlas-based analysis of diffusion tensor imaging may reveal focal axonal injuries in mild traumatic brain injury -- comparison with diffuse axonal injury.

  2012cited by this paper
• Do brain activation changes persist in athletes with a history of multiple concussions who are asymptomatic?

  2012cited by this paper
• Default Mode Network in Concussed Individuals in Response to the YMCA Physical Stress Test

  2012cited by this paper
• The Less BOLD, the Wiser: Support for the latent resource hypothesis after traumatic brain injury

  2012cited by this paper
• Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury

  2012cited by this paper
• Embracing chaos: the scope and importance of clinical and pathological heterogeneity in mTBI

  2012influential reference
• Concussion in athletics: ongoing clinical and brain imaging research controversies

  2012influential reference
• Functional MRI of mild traumatic brain injury (mTBI): progress and perspectives from the first decade of studies

  2012influential reference
• Lack of long-term fMRI differences after multiple sports-related concussions

  2012cited by this paper
• Post-concussion syndrome: Prevalence after mild traumatic brain injury in comparison with a sample without head injury

  2012cited by this paper
• Metabolic imaging of mild traumatic brain injury

  2012cited by this paper
• Emerging Imaging Tools for Use with Traumatic Brain Injury Research

  2012influential reference
• Functional connectivity in mild traumatic brain injury

  2011influential reference
• Thalamic resting-state functional networks: disruption in patients with mild traumatic brain injury.

  2011cited by this paper
• A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion.

  2011cited by this paper
• Default mode network functional and structural connectivity after traumatic brain injury.

  2011cited by this paper
• Alteration of brain functional network at rest and in response to YMCA physical stress test in concussed athletes: RsFMRI study

  2011cited by this paper
• Imaging Modalities in Mild Traumatic Brain Injury and Sports Concussion

  2011influential reference
• Default Mode Network Connectivity Predicts Sustained Attention Deficits after Traumatic Brain Injury

  2011cited by this paper
• Examining working memory task acquisition in a disrupted neural network.

  2011cited by this paper
• Diagnostic and Statistical Manual of Mental Disorders

  2010cited by this paper
• Rates of symptom reporting following traumatic brain injury

  2010cited by this paper
• The Nature of Processing Speed Deficits in Traumatic Brain Injury: is Less Brain More?

  2010cited by this paper
• Microstructural brain injury in post-concussion syndrome after minor head injury

  2010cited by this paper
• Are functional deficits in concussed individuals consistent with white matter structural alterations: combined FMRI & DTI study

  2010cited by this paper
• How Mild Traumatic Brain Injury May Affect Declarative Memory Performance in the Post-Acute Stage

  2010influential reference
• Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

  2010influential reference
• Use of SVM Methods with Surface-Based Cortical and Volumetric Subcortical Measurements to Detect Alzheimer's Disease

  2010cited by this paper
• Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study

  2010influential reference
• Postconcussive Symptoms Are Associated With Compensatory Cortical Recruitment During a Working Memory Task

  2010cited by this paper
• [Phoniatricians aspect of international statistical classification of diseases and related health problems].

  2009cited by this paper
• Early clinical characteristics of patients with persistent post-concussion symptoms: A prospective study

  2009cited by this paper
• Bayesian analysis of neuroimaging data in FSL

  2009cited by this paper
• Evaluating SVM and MLDA in the extraction of discriminant regions for mental state prediction

  2009cited by this paper
• Post-concussion symptoms after traumatic brain injury at 3 and 12 months post-injury: A prospective study

  2009influential reference
• Symptom complaints following combat-related traumatic brain injury: Relationship to traumatic brain injury severity and posttraumatic stress disorder

  2009cited by this paper
• Prevalence and structure of symptoms at 3 months after mild traumatic brain injury in a national cohort

  2009cited by this paper
• Postconcussion syndrome after minor head injury: Brain activation of working memory and attention

  2009influential reference
• Post-traumatic amnesia and the nature of post-traumatic stress disorder after mild traumatic brain injury

  2009cited by this paper
• The Predictive Brain State: Timing Deficiency in Traumatic Brain Injury?

  2008cited by this paper
• Hospital admissions with head injury following publication of NICE guidance

  2008influential reference
• Diffusion Tensor Imaging Characteristics of the Corpus Callosum in Mild, Moderate, and Severe Traumatic Brain Injury

  2008cited by this paper
• MMPI-2 profiles 23 years after paediatric mild traumatic brain injury

  2008cited by this paper
• MR imaging in the detection of diffuse axonal injury with mild traumatic brain injury

  2008cited by this paper
• Focal Lesions in Acute Mild Traumatic Brain Injury and Neurocognitive Outcome: CT versus 3T MRI

  2008cited by this paper
• Symptoms of post-concussional syndrome are non-specifically related to mild traumatic brain injury in UK Armed Forces personnel on return from deployment in Iraq: an analysis of self-reported data

  2008cited by this paper
• Recent neuroimaging techniques in mild traumatic brain injury.

  2007cited by this paper
• Cognitive complaints after mild traumatic brain injury: things are not always what they seem.

  2007cited by this paper
• Objective Documentation of Traumatic Brain Injury Subsequent to Mild Head Trauma: Multimodal Brain Imaging With MEG, SPECT, and MRI

  2007cited by this paper
• Neuropsychology and clinical neuroscience of persistent post-concussive syndrome

  2007cited by this paper
• Examination of postconcussion-like symptoms in healthy university students: relationships to subjective and objective neuropsychological function performance.

  2006cited by this paper
• Symptoms and disability until 3 months after mild TBI

  2006cited by this paper
• Misdiagnosis of the persistent postconcussion syndrome in patients with depression.

  2006cited by this paper
• The impact of motivation on neuropsychological performance in sports-related mild traumatic brain injury

  2006cited by this paper
• Are mild head injuries as mild as we think? Neurobehavioral concomitants of chronic post-concussion syndrome

  2006cited by this paper
• Incidence of Traumatic Brain Injury in the United States, 2003

  2006influential reference
• The Epidemiology and Impact of Traumatic Brain Injury: A Brief Overview

  2006cited by this paper
• Knowledge and expectation of postconcussion symptoms in the general population.

  2006cited by this paper
• Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study

  2006influential reference
• Assessing the enduring residual neuropsychological effects of head trauma in college athletes who participate in contact sports.

  2005cited by this paper
• Mild traumatic brain injury in the United States, 1998–2000

  2005cited by this paper
• N‐back working memory paradigm: A meta‐analysis of normative functional neuroimaging studies

  2005cited by this paper
• Outcome from mild traumatic brain injury

  2005cited by this paper
• Advances in functional and structural MR image analysis and implementation as FSL.

  2004cited by this paper
• Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury.

  2004influential reference
• Post-traumatic syndrome after minor head injury cannot be predicted by neurological investigations.

  2004cited by this paper
• Post concussion syndrome

  2003cited by this paper
• A paced visual serial addition test for fMRI.

  2003cited by this paper
• Differential Working Memory Load Effects after Mild Traumatic Brain Injury

  2001influential reference
• Functional magnetic resonance imaging of working memory impairment after traumatic brain injury

  2001influential reference
• Paced Visual Serial Addition Test: An Alternative Measure of Information Processing Speed

  1999cited by this paper
• Brain activation during working memory 1 month after mild traumatic brain injury

  1999cited by this paper
• Incidence of mild and moderate brain injury in the United States, 1991.

  1996cited by this paper
• [Post-concussion syndrome].

  1995cited by this paper
• Book Reviews : International Statistical Classification of Diseases and Related Health Problems 10th Revision, Vol 2. Instruction Manual. by World Health Organisation, 1993. 160 pp, Sw fr 40. Hardback. ISBN: 92-4-154420-1

  1994cited by this paper
• Estimation of metabolite concentrations from localized in vivo proton NMR spectra

  1993cited by this paper
• Symptoms following mild head injury: expectation as aetiology.

  1992cited by this paper
• The National Adult Reading Test

  1982cited by this paper

• Advancements in diagnosing Post-concussion Syndrome: insights into epidemiology, pathophysiology, neuropathology, neuroimaging, and salivary biomarkers

  2025cites this paper
• Functional Connectivity Patterns Following Mild Traumatic Brain Injury and the Association With Longitudinal Cognitive Function

  2025cites this paper
• Evidence for Altered White Matter Organization After Mild Traumatic Brain Injury: A Scoping Review on the Use of Diffusion Magnetic Resonance Imaging and Blood-Based Biomarkers to Investigate Acute Pathology and Relationship to Persistent Post-Concussion Symptoms

  2024cites this paper
• The structural, functional, and neurophysiological connectome of mild traumatic brain injury: A DTI, fMRI and MEG multimodal clustering and data fusion study

  2024cites this paper
• Return to Play Following Concussion: Role for Imaging?

  2024influential citation
• Neuromechanical Models of Mild Traumatic Brain Injury Conditioned on Reaction Time: A Systematic Review and Meta-Analysis

  2024cites this paper
• Metabolite changes and impact factors in mild traumatic brain injury patients: a review on magnetic resonance spectroscopy

  2024cites this paper
• Dual task cost in adults with persistent concussion symptoms.

  2023cites this paper
• Impact of averaging fNIRS regional coherence data when monitoring people with long term post-concussion symptoms

  2023cites this paper
• Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

  2023cites this paper
• Magnetic Resonance Spectroscopy of Traumatic Brain Injury and Subconcussive Hits: A Systematic Review and Meta–Analysis

  2022cites this paper
• Recovery of clinical, cognitive and cortical activity measures following mild traumatic brain injury (mTBI): a longitudinal investigation

  2022cites this paper
• Long-Term Changes in Brain Connectivity Reflected in Quantitative Electrophysiology of Symptomatic Former National Football League Players

  2022cites this paper
• Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature

  2021cites this paper
• Emotional Modulation of Frontal Alpha Asymmetry - a Novel Biomarker of Mild Traumatic Brain Injury

  2021cites this paper
• How mental fatigue influences neurovascular coupling in post-concussion syndrome : a preliminary pilot study

  2021cites this paper
• Translational neuroimaging in mild traumatic brain injury

  2021cites this paper
• Diffusion and functional MRI findings and their relationship to behaviour in postconcussion syndrome: a scoping review

  2021cites this paper
• Application of Magnetic Resonance Spectroscopy in Neurocognitive Assessment After Head Injury: A Systematic Review

  2021cites this paper
• A preliminary investigation of cognitive intolerance and neuroimaging among adolescents returning to school after concussion

  2020cites this paper
• Multimodal Dynamic Brain Connectivity Analysis Based on Graph Signal Processing for Former Athletes With History of Multiple Concussions

  2020cites this paper
• The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

  2020influential citation
• What Is a Concussive Brain Injury?

  2019cites this paper
• Comparing Region of Interest versus Voxel-Wise Diffusion Tensor Imaging Analytic Methods in Mild and Moderate Traumatic Brain Injury: A Systematic Review and Meta-Analysis

  2019cites this paper
• Rehabilitation Assessment and Management of Neurosensory Deficits After Traumatic Brain Injury in the Polytrauma Veteran.

  2019cites this paper
• Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome

  2019cites this paper
• Fatigue after traumatic brain injury : exploring novel methods for diagnosis and treatment

  2019cites this paper
• Postconcussion symptom reporting is not associated with diffusion tensor imaging findings in the subacute to chronic phase of recovery in military service members following mild traumatic brain injury

  2019cites this paper
• Functional Neuroimaging Markers of Persistent Post-Concussive Brain Change

  2019cites this paper
• Impact of mild traumatic brain injury on cingulate functions.

  2019cites this paper
• A Systematic Review of Structural and Functional Imaging Correlates of Headache or Pain after Mild Traumatic Brain Injury

  2019cites this paper
• GSP Analysis of Brain Imaging Data from Athletes with History of Multiple Concussions

  2019cites this paper
• Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury

  2019cites this paper
• Imaging Post-Traumatic Headache

  2018cites this paper
• Reduced Functional Connectivity in Adults with Persistent Post-Concussion Symptoms: A Functional Near-Infrared Spectroscopy Study

  2018cites this paper
• Discovery of Therapy-targeting Biomarkers for Post-Concussion Syndrome using Functional Neurocognitive Imaging

  2018cites this paper
• Cognitive Function and Dynamic Cerebral Blood Flow Regulation in Multiple Concussions

  2018cites this paper
• Altered segregation between task-positive and task-negative regions in mild traumatic brain injury

  2018cites this paper
• Multimodal Imaging of Retired Professional Contact Sport Athletes Does Not Provide Evidence of Structural and Functional Brain Damage

  2018cites this paper
• Diffusion tensor imaging changes following mild, moderate and severe adult traumatic brain injury: a meta-analysis

  2018cites this paper
• Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.

  2018cites this paper
• Magnetic resonance spectroscopy abnormalities in traumatic brain injury: A meta-analysis.

  2017cites this paper
• Concussion As a Multi-Scale Complex System: An Interdisciplinary Synthesis of Current Knowledge

  2017cites this paper
• High-Density Electroencephalographic Recordings During Sleep in Children and Adolescents With Acquired Brain Injury

  2017cites this paper
• A Prospective Transcranial Doppler Ultrasound-Based Evaluation of the Acute and Cumulative Effects of Sport-Related Concussion on Neurovascular Coupling Response Dynamics

  2017cites this paper
• Neurovascular Coupling: A Unifying Theory for Post-Concussion Syndrome Treatment and Functional Neuroimaging

  2017cites this paper
• Adaptive reorganization of retinogeniculate axon terminals in dorsal lateral geniculate nucleus following experimental mild traumatic brain injury

  2017influential citation
• Understanding the interplay between mild traumatic brain injury and cognitive fatigue: models and treatments

  2017influential citation
• Pediatric Mild Traumatic Brain Injury in the Acute Setting

  2017cites this paper
• Potential for use of creatine supplementation following mild traumatic brain injury

  2017cites this paper
• Nutrition as Medicine to Improve Outcomes in Adolescents Sustaining a Sports-related Concussion

  2017cites this paper
• A prospective, multidisciplinary approach to understanding sport-related head trauma : novel insights into the effects on myelin and cerebrovascular function

  2017cites this paper
• The neurological, neuroimaging and neuropsychological effects of playing professional football: Results of the UK five-year follow-up study

  2016cites this paper
• Neural Control of Posture in Individuals with Persisting Postconcussion Symptoms.

  2016cites this paper
• Berufliche Wiedereingliederung in der ambulanten neurologischen Rehabilitation

  2016cites this paper
• Concussion in the Military: an Evidence-Base Review of mTBI in US Military Personnel Focused on Posttraumatic Headache

  2016cites this paper
• Multimodal neuroimaging computing: the workflows, methods, and platforms

  2015cites this paper
• Using 9.4T MRI To Investigate Parenchymal And Vascular Changes In An Animal Model Of Pediatric Mild Traumatic Brain Injury

  2015cites this paper
• Multimodal neuroimaging computing: the workflows, methods, and platforms.

  2015cites this paper
• Multimodal neuroimaging computing: a review of the applications in neuropsychiatric disorders

  2015cites this paper
• Multimodal neuroimaging computing: a review of the applications in neuropsychiatric disorders

  2015cites this paper
• Altered Resting-State Connectivity within Executive Networks after Aneurysmal Subarachnoid Hemorrhage

  2015cites this paper