The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  American Journal of Respiratory and Critical Care Medicine

• Publication date

  2007-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1164/RCCM.200606-839OCPMID 17095748PMCID PMC1899265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemokine scavenging by D6: a movable feast?

  2006cited by this paper
• Reduced expression of transforming growth factor β1 exacerbates pathology in an experimental asthma model

  2005cited by this paper
• The chemokine receptor D6 limits the inflammatory response in vivo

  2005cited by this paper
• Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough.

  2005cited by this paper
• Manipulation of Allergen-Induced Airway Remodeling by Treatment with Anti-TGF-β Antibody: Effect on the Smad Signaling Pathway1

  2005cited by this paper
• Increased inflammation in mice deficient for the chemokine decoy receptor D6

  2005cited by this paper
• Differential Recognition and Scavenging of Native and Truncated Macrophage-Derived Chemokine (Macrophage-Derived Chemokine/CC Chemokine Ligand 22) by the D6 Decoy Receptor1

  2004influential reference
• CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge

  2004cited by this paper
• CCR4 blockade does not inhibit allergic airways inflammation

  2003cited by this paper
• TGF-β Regulates Airway Responses Via T Cells 1

  2003cited by this paper
• TGF-beta regulates airway responses via T cells.

  2003cited by this paper
• Marked Airway Eosinophilia Prevents Development of Airway Hyper-responsiveness During an Allergic Response in IL-5 Transgenic Mice1

  2003cited by this paper
• Cytokines and chemoattractants in allergic inflammation.

  2002cited by this paper
• In vitro assessment of chemokine receptor‐ligand interactions mediating mouse eosinophil migration

  2002cited by this paper
• Plasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthma.

  2002cited by this paper
• Increased levels of a TH2‐type CC chemokine thymus and activation‐regulated chemokine (TARC) in serum and induced sputum of asthmatics

  2002cited by this paper
• The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.

  2001cited by this paper
• Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines.

  2001cited by this paper
• The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics.

  2001cited by this paper
• CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation.

  2000cited by this paper
• A Key Role for Cc Chemokine Receptor 4 in Lipopolysaccharide-Induced Endotoxic Shock

  2000cited by this paper
• Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression1

  2000cited by this paper
• LD78β, A Non-allelic Variant of Human MIP-1α (LD78α), Has Enhanced Receptor Interactions and Potent HIV Suppressive Activity*

  1999cited by this paper
• Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3*

  1999cited by this paper
• Allergic lung responses are increased in prostaglandin H synthase-deficient mice.

  1999cited by this paper
• Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.

  1999cited by this paper
• Interleukin-13: central mediator of allergic asthma.

  1998cited by this paper
• Interleukin-13: central mediator of allergic asthma

  1998cited by this paper
• Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

  1998cited by this paper
• Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

  1998cited by this paper
• Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.

  1997cited by this paper
• Cloning and Characterization of a Novel Murine β Chemokine Receptor, D6

  1997cited by this paper
• Human Macrophage–derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells

  1997cited by this paper
• Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

  1996cited by this paper
• Cloning and Functional Expression of a Human Eosinophil CC Chemokine Receptor (*)

  1995cited by this paper
• Molecular characterization of two murine eosinophil beta chemokine receptors.

  1995cited by this paper
• Characterization of a murine model of allergic pulmonary inflammation.

  1994cited by this paper
• InflammationTLR4 Signaling Attenuates Ongoing Allergic

  year unknowncited by this paper

• Bystander Expression of Atypical Chemokine Receptor 2 Protects T Cells from Chemoattraction towards Cancer‐Associated Fibroblasts

  2025cites this paper
• Chemokines in the resolution of inflammation: key players and targets for therapeutic modulation

  2025cites this paper
• The Chemokine System as a Key Regulator of Pulmonary Fibrosis: Converging Pathways in Human Idiopathic Pulmonary Fibrosis (IPF) and the Bleomycin-Induced Lung Fibrosis Model in Mice

  2024cites this paper
• The role of DNA methylation in personalized medicine for immune-related diseases.

  2023cites this paper
• Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis.

  2023cites this paper
• The mechanism of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury.

  2023cites this paper
• New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

  2023cites this paper
• The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both?

  2022cites this paper
• The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis

  2022cites this paper
• ACKR2 contributes to pulmonary dysfunction by shaping CCL5:CCR5-dependent recruitment of lymphocytes during Influenza A infection in mice.

  2020cites this paper
• Role of Atypical Chemokines and Chemokine Receptors Pathways In the Pathogenesis of Copd.

  2020cites this paper
• A novel methodology for defining stromal expression of atypical chemokine receptors in vivo

  2019cites this paper
• G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis

  2019cites this paper
• The Atypical Chemokine Receptor 2 Limits Progressive Fibrosis after Acute Ischemic Kidney Injury.

  2019cites this paper
• Analysis of lung stromal expression of the atypical chemokine receptor ACKR2 reveals unanticipated expression in murine blood endothelial cells

  2019cites this paper
• Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission

  2019cites this paper
• The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2+ and CCR5+ IFNγ-producing γδT cells in mice.

  2018cites this paper
• Mast Cell–Dependent CD8+ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in ApcMin/+ Mice

  2018cites this paper
• The atypical chemokine receptor 2 limits renal inflammation and fibrosis in murine progressive immune complex glomerulonephritis.

  2018cites this paper
• Elevated ACKR2 expression is a common feature of inflammatory arthropathies

  2017cites this paper
• The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

  2017cites this paper
• ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology

  2017cites this paper
• Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

  2016cites this paper
• MMP-9 Metallo protease 9 1 The Chemokine Universe

  2016cites this paper
• Leukocyte chemoattractant receptors in human disease pathogenesis.

  2015cites this paper
• Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice

  2015cites this paper
• Chemokine decoy receptor D6 mimicking trap (D6MT) prevents allosensitization and immune rejection in murine corneal allograft model

  2015cites this paper
• The role of the atypical chemokine receptor D6 in the placenta

  2014cites this paper
• The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding*

  2014cites this paper
• Lymphatic Regulation of Cellular Trafficking.

  2014cites this paper
• The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens

  2014cites this paper
• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

  2014cites this paper
• Biochemical features important for D6 function

  2014cites this paper
• The effects of dietary fish oil on the induction and resolution of antigen-induced inflammation

  2014cites this paper
• Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection

  2013cites this paper
• Microarray Analyses Demonstrate the Involvement of Type I Interferons in Psoriasiform Pathology Development in D6-deficient Mice*

  2013cites this paper
• Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6

  2013cites this paper
• Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection

  2013cites this paper
• Role of Abl in airway hyperresponsiveness and airway remodeling

  2013cites this paper
• Immune regulation by atypical chemokine receptors

  2013cites this paper
• Expression of the chemokine decoy receptor D6 is decreased in colon adenocarcinomas

  2013cites this paper
• D6: the 'crowd controller' at the immune gateway.

  2013cites this paper
• Dietary fish oil reduces the acute inflammatory response and enhances resolution of antigen-induced peritonitis.

  2013cites this paper
• Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD.

  2013cites this paper
• Cell-Autonomous Regulation of Neutrophil Migration by the D6 Chemokine Decoy Receptor

  2013cites this paper
• Review: Structure-function and biological properties of the atypical chemokine receptor D6.

  2013cites this paper
• Mast cell-T cell interactions in inflammatory chemokine mediated immune surveillance of intestinal cancer.

  2013cites this paper
• Characterising receptors for the chemokine CCL2, and their differential expression on dendritic cell subsets

  2013cites this paper
• activities by atypical chemokine receptor D6 Control of murine Ly6Chigh monocyte traffic and immunosuppressive

  2013cites this paper
• Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells.

  2013cites this paper
• ReceptorMigration by the D6 Chemokine Decoy Cell-Autonomous Regulation of Neutrophil

  2013cites this paper
• Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.

  2012cites this paper
• suppressing lymphatic congestion D6 facilitates cellular migration and fluid flow to lymph nodes by

  2012cites this paper
• The biochemistry and biology of the atypical chemokine receptors.

  2012cites this paper
• The TLR5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens

  2012cites this paper
• Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis.

  2012cites this paper
• The atypical chemokine receptor D6 controls macrophage efferocytosis and cytokine secretion during the resolution of inflammation

  2012cites this paper
• CCL2 binding is CCR2 independent in primary adult human astrocytes.

  2012cites this paper
• Control of murine Ly 6 Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D 6 *

  2012cites this paper
• activities by atypical chemokine receptor D6 monocyte traffic and immunosuppressive high Control of murine Ly6C

  2012cites this paper
• An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis

  2011cites this paper
• Down-regulation of chemokine Ccl5 gene expression in the NTS of SHR may be pro-hypertensive

  2011cites this paper
• Chemokines in transplantation: what can atypical receptors teach us about anti-inflammatory therapy?

  2011cites this paper
• Contributions of vascular inflammation in the brainstem for neurogenic hypertension.

  2011cites this paper
• D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion.

  2011cites this paper
• DARC and D6: silent partners in chemokine regulation?

  2011cites this paper
• The atypical chemokine receptors

  2011cites this paper
• The role of D6 in neutrophil migration, melanoma growth and metastasis

  2011cites this paper
• Atypical chemokine receptors

  2011cites this paper
• Expression and function of the atypical chemokine receptor CCX-CKR

  2011cites this paper
• Recipients Embryos Transferred into Allogeneic Trophoblasts and Aids the Survival of Mouse Chemokine Scavenger D 6 Is Expressed by and

  2010cites this paper
• Chemokines in Liver Inflammation and Fibrosis

  2010cites this paper
• Chemokine patterning by glycosaminoglycans and interceptors.

  2010cites this paper
• Cardiovascular , Pulmonary and Renal Pathology A Novel Mechanism for CCR 4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

  2010influential citation
• Assessment of the therapeutic potential of the atypical chemokine receptor, D6

  2010cites this paper
• Chemokines as Immune Mediators of Liver Diseases Related to the Metabolic Syndrome

  2010cites this paper
• Chemokine decoy receptors: structure-function and biological properties.

  2010cites this paper
• Modulation of Allergic Airway Inflammation by the Oral Pathogen Porphyromonas gingivalis

  2010cites this paper
• Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients

  2010cites this paper
• D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes

  2009cites this paper
• Review Paper: The Role of Inflammation in Mouse Pulmonary Neoplasia

  2009cites this paper
• TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils

  2009cites this paper
• The Roles of Chemokines and Chemokine Receptors in Prostate Cancer

  2009cites this paper
• The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis 1

  2009cites this paper
• Structure-function dissection of D6, an atypical scavenger receptor.

  2009cites this paper
• The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo

  2009cites this paper
• Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.

  2009cites this paper
• Interaction of tgf-beta with immune cells in airway disease.

  2008cites this paper
• Hemopoietic Cell Expression of the Chemokine Decoy Receptor D6 Is Dynamic and Regulated by GATA11

  2008cites this paper
• Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1

  2008cites this paper
• Chemokine Decoy Receptor D6 Plays a Negative Role in Human Breast Cancer

  2008cites this paper
• and Regulated by GATA1 Chemokine Decoy Receptor D6 Is Dynamic Hemopoietic Cell Expression of the

  2008cites this paper
• Update in asthma 2007.

  2008cites this paper
• Multiple Roles for the C-terminal Tail of the Chemokine Scavenger D6*

  2008cites this paper
• A Review of Molecular Contrasts Between Arresting and Viable Porcine Attachment Sites

  2007cites this paper
• Innate immune control of pulmonary dendritic cell trafficking.

  2007cites this paper
• Professional and Part-Time Chemokine Decoys in the Resolution of Inflammation

  2007cites this paper
• The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors.

  2007cites this paper