Relationship of germinal centers in lymphoid tissue to immunologic memory. V. The effect of prednisolone administered after the peak of the primary response.

A study was made of the primary and secondary immune responses in 3- to 4- week-old rabbits that received prednisolone treatment on days 5 to 13 after primary injection of alum-precipitated bovine γ globulin into the hind footpads. The treatment did not affect the primary response but completely inhibited preparation for a secondary response induced by challenge with soluble bovine γ globulin 14 days after the primary injection. Histologic examination of popliteal lymph nodes demonstrated that prednisolone treatment interfered with germinal center production, which may have been related to the inhibition of priming for the secondary response.

• Publication year

  1971

• Venue

  Journal of Immunology

• Publication date

  1971-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.106.4.1079PMID 4101773
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of Immunosuppressive Agents on Retention of Antigen in the Mouse Spleen 1

  1970cited by this paper
• THE PROLIFERATIVE AND ANAMNESTIC ANTIBODY RESPONSE OF RABBIT LYMPHOID CELLS IN VITRO

  1969cited by this paper
• Studies on the cellular basis of IgM immunological memory.

  1969cited by this paper
• Antigen in tissues. IV. The effect of antibody on the retention and localization of antigen in rat lymph nodes.

  1967cited by this paper
• Gamma-globulin and antibody formation in vitro. V. The secondary response made by splenic white and red pulp with reference to the role of secondary nodules.

  1966cited by this paper
• [Cell formation and cellular breakdown in the centres of secondary lymph follicles of the mouse].

  1966cited by this paper
• Antigens in immunity. VII. Analysis of immunological memory.

  1965cited by this paper
• The immunoglobulin sequence. I. Arrest by 6-mercaptopurine and restitution by antibody, antigen or splenectomy.

  1965cited by this paper
• STUDIES ON ANTIBODY PRODUCTION

  1964cited by this paper
• SUPPRESSION OF ANTIBODY SYNTHESIS AND PROLONGATION OF HOMOGRAFT SURVIVAL BY CHLORAMPHENICOL

  1964cited by this paper
• STUDIES ON ANTIBODY PRODUCTION

  1964cited by this paper
• GAMMA GLOBULIN AND ANTIBODY FORMATION IN VITRO. IV. THE EFFECT ON THE SECONDARY RESPONSE OF X-IRRADIATION GIVEN AT VARYING INTERVALS AFTER A PRIMARY INJECTION OF BOVINE GAMMA- GLOBULIN.

  1964cited by this paper
• ANTIBODY FORMATION

  1963cited by this paper
• Prevention of secondary immune response with 6-mercaptopurine.

  1962cited by this paper
• GAMMA GLOBULIN AND ANTIBODY FORMATION IN VITRO

  1962cited by this paper
• The effect of 6-mercaptopurine on primary and secondary immune responses.

  1959cited by this paper
• Drug-induced Immunological Tolerance

  1959cited by this paper
• Dissociation of human serum macroglobulins.

  1957cited by this paper
• Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.

  1954cited by this paper

• Eosinophils Regulate Type 2 Immune Responses Following Infection with the Nematode Trichinella spiralis

  2016influential citation
• Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy

  2015cites this paper
• Crucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity

  2014cites this paper
• Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.

  2014cites this paper
• How oligoclonal are germinal centers? A new method for estimating clonal diversity from immunohistological sections

  2013cites this paper
• Chapter 4 – Hemopoietic and Lymphatic Systems

  2012cites this paper
• Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis

  2011cites this paper
• Age-Associated Decline in Peripheral Lymphoid Organ Functions

  2011cites this paper
• Reassessing Germinal Centre Reaction Concepts

  2011cites this paper
• Role of germinal centers in the generation of B cell memory

  2008cites this paper
• Lectin panning method: the prospective isolation of mouse neural progenitor cells by the attachment of cell surface N-glycans to Phaseolus vulgaris erythroagglutinating lectin-coated dishes.

  2008cites this paper
• SAP-controlled T-B cell interactions underlie germinal centre formation

  2008cites this paper
• New markers for murine memory B cells that define mutated and unmutated subsets

  2007cites this paper
• Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation

  2007cites this paper
• Haemopoietic and Lymphatic Systems

  2007cites this paper
• Re‐evaluating the recycling hypothesis in the germinal centre

  2006cites this paper
• Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization

  2005cites this paper
• Follicular Dendritic Cell Regulation of CXCR4-Mediated Germinal Center CD4 T Cell Migration1

  2004cites this paper
• Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.

  2004cites this paper
• Cytokine Control of Memory B Cell Homing Machinery1

  2002cites this paper
• Spontaneous formation of germinal centers in autoimmune mice

  2001cites this paper
• Attractions and migrations of lymphoid cells in the organization of humoral immune responses.

  2001cites this paper
• B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae1 2

  2000cites this paper
• Lymphocytes Lacking IκB-α Develop Normally, But Have Selective Defects in Proliferation and Function1

  2000cites this paper
• Antigen-Specific B Cell Memory

  2000cites this paper
• Overview of Germinal Center Function and Structure in Normal and Genetically Engineered Mice

  1998cites this paper
• Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

  1998cites this paper
• Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells

  1998cites this paper
• Transfer of primitive stem/progenitor bone marrow cells from LT alpha-/- donors to wild-type hosts: implications for the generation of architectural events in lymphoid B cell domains.

  1998cites this paper
• Regulation of Promoter and Intron Enhancer Activity in Immunoglobulin Heavy‐Chain Genes during B‐Cell Differentiation

  1998cites this paper
• IgD can largely substitute for loss of IgM function in B cells

  1998cites this paper
• Regulation of Peripheral B-Cell Growth and Differentiation

  1996cites this paper
• Follicular dendritic cells: antigen retention, B cell activation, and cytokine production.

  1995cites this paper
• Dark and light zones of germinal centres of the human tonsil: an ultrastructural study with emphasis on heterogeneity of follicular dendritic cells

  1992cites this paper
• The structure of the immune system and the relationship between its components

  1991cites this paper
• Maturation of the immune response in germinal centers.

  1991cites this paper
• Expansion, selection and maintenance of memory B-cell clones.

  1990cites this paper
• Germinal center reaction and B lymphocytes: morphology and function.

  1990cites this paper
• Control of IgE responses.

  1989cites this paper
• Cytological basis of immune functions of the spleen. Immunocytochemical characterization of lymphoid and non-lymphoid cells involved in the 'in situ' immune response.

  1989cites this paper
• Impact of IgD receptor-positive T cells on the immune response.

  1988cites this paper
• A subpopulation of germinal center B cells differentiate directly into antibody forming cells upon secondary immunization.

  1988cites this paper
• Lymphocyte Homing Receptors, Ubiquitin, and Cell Surface Proteins

  1988cites this paper
• The regulation of lymphocyte traffic.

  1986cites this paper
• Prospects for understanding the role of lymphoid microenvironments in B cell differentiation in vivo.

  1985cites this paper
• Immune suppression and histophysiology of the immune response

  1983cites this paper
• [Immunobiological effects of a decimeter-range electromagnetic field in its exposure over the area of the thyroid gland].

  1983cites this paper
• Developments in drugs enhancing the immune responses.

  1981cites this paper
• Separation of memory cell subpopulations by complement receptors: in vivo analysis

  1980cites this paper
• Germinal centers in the spleens of neonates and stillbirths.

  1978cites this paper
• [Cellular basis for immunologic memory].

  1977cites this paper
• Development of germinal centres in the spleen in infants related to birth and unexpected death.

  1976cites this paper
• Cardiac surgery and Immunology

  1975cites this paper
• Antibody formation in mouse bone marrow. IV. The influence of splenectomy on the bone marrow plaque-forming cell response to sheep red blood cells.

  1975cites this paper
• Infection of capuchin monkeys (Cebus albifrons) with Herpesvirus saimiri.

  1975cites this paper
• 5‐Hydroxytryptophan effect on the development of the immune response: IgM and IgG antibodies and rosette formation in primary and secondary responses

  1975cites this paper
• Identification of a highly specific memory T cell population: lack of a B cell counterpart.

  1974cites this paper
• Antibody formation in mouse bone marrow. II. Evidence for a memory-dependent phenomenon.

  1974cites this paper
• Chapter 3 – Evaluation for Immunosuppressive and Antiallergic Activity

  1974cites this paper
• Antibody formation in mouse bone marrow. III. Effects of route of priming and antigen dose.

  1974cites this paper
• IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

  1974cites this paper
• Cortisone interfering with the production of "T and B cells".

  1973cites this paper
• Preferential destruction of germinal centers by prednisolone and x-irradiation.

  1972cites this paper
• Bursa of fabricius as site of origin of germinal centre cells.

  1972cites this paper
• Studies on the germinal center. IV. Autoradiographic study of lymph node germinal centers in relation to zonal differentiation.

  1972cites this paper
• Studies in Infantile Marasmus. IV. Impairment of Immunologic Responses in the Marasmic Pig

  1972cites this paper
• Regeneration, Hyperplasie und Onkogenese der lymphoretikulären Organe

  1969cites this paper