Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats.

The effects of single IV injections of sodium bicarbonate (0.5 mEq/kg of body weight, 1 mEq/kg, 2 mEq/kg, and 4 mEq/kg) on serum osmolality, serum sodium, chloride, and potassium concentrations, and venous blood gas tensions in 6 healthy cats were monitored for 180 minutes. Serum osmolality increased and remained significantly (P less than 0.05) increased for 120 minutes in cats given 4 mEq of sodium bicarbonate/kg. Serum sodium was increased significantly (P less than 0.05) for 30 minutes in cats given 4 mEq of sodium bicarbonate/kg. Serum sodium decreased and remained significantly (P less than 0.05) decreased for 120 minutes in cats given 1 g of 20% mannitol/kg, and serum osmolality was significantly (P less than 0.05) decreased at 30 and 60 minutes. Serum chloride decreased significantly (P less than 0.05) for 10 minutes in cats given 1 mEq of sodium bicarbonate/kg, and was significantly decreased for 30 minutes in cats given 2 mEq and 4 mEq of sodium bicarbonate/kg. Serum chloride decreased and remained significantly (P less than 0.05) decreased for 30 minutes in cats given 1 g of 20% mannitol/kg. Serum sodium and serum osmolality did not change significantly (P less than 0.05) in cats given 4 ml of 0.9% sodium chloride/kg. Serum potassium decreased significantly (P less than 0.05) for 10 minutes in cats given 1 mEq of sodium bicarbonate/kg, and for 120 minutes in cats given 2 mEq/kg or 4 mEq/kg. There was a significantly (P less than 0.05) greater decrease in serum potassium that lasted for 30 minutes after given sodium bicarbonate at the dosage of 4 mEq/kg, compared with other dosages given.(ABSTRACT TRUNCATED AT 250 WORDS)

• Publication year

  1991

• Venue

  American Journal of Veterinary Research

• Publication date

  1991-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2460/ajvr.1991.52.01.12PMID 1850584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of acute hyperventilation on serum potassium in the dog.

  1990cited by this paper
• Feline kaliopenic polymyopathy/nephropathy syndrome.

  1989cited by this paper
• Effect of sodium bicarbonate infusions on ionized calcium and total calcium concentrations in serum of clinically normal cats.

  1989cited by this paper
• Disorders of potassium homeostasis.

  1989cited by this paper
• The danger of high dose sodium bicarbonate in biguanide‐induced lactic acidosis: the theory, the practice and alternative therapies

  1987cited by this paper
• 3% NaCl and 7.5% NaCl/dextran 70 in the resuscitation of severely injured patients.

  1987cited by this paper
• Effects of Sodium Bicarbonate in Canine Hemorrhagic Shock

  1987cited by this paper
• A comparison of several hypertonic solutions for resuscitation of bled sheep.

  1985cited by this paper
• Small-volume resuscitation with hypertonic saline (2,400 mOsm/liter) during hemorrhagic shock.

  1984cited by this paper
• Impairment of extrarenal potassium disposal by alpha-adrenergic stimulation.

  1984cited by this paper
• Effects of acidemia and sodium bicarbonate therapy in advanced cardiac life support.

  1984cited by this paper
• Changes in plasma potassium concentration during acute acid-base disturbances.

  1981cited by this paper
• Sodium bicarbonate and bicarbonate precursors for treatment of metabolic acidosis.

  1981cited by this paper
• Intracranial Hemorrhage Following Intravenous Administration of Sodium Bicarbonate or Saline Solution in the Newborn Lamb Asphyxiated in Utero

  1979cited by this paper
• Correction of hyperkalemia by bicarbonate despite constant blood pH.

  1977cited by this paper
• Sodium bicarbonate administration during cardiac arrest. Effect on arterial pH PCO2, and osmolality.

  1976cited by this paper
• Cardiac arrest in the critically ill. II. Hyperosmolal states following cardiac arrest.

  1974cited by this paper
• Hypernatremia and intracranial hemorrhage in neonates.

  1974cited by this paper
• Clinically significant physiologic changes from rapidly administered hypertonic solutions: acute osmol poisoning.

  1970cited by this paper
• Reflex systemic hypotension due to hypertonic solutions in pulmonary circulation.

  1969cited by this paper
• Increase in serum potassium resulting from the administration of hypertonic mannitol and other solutions.

  1969cited by this paper
• Influence of sodium bicarbonate on myocardial performance.

  1967cited by this paper
• Pathogenesis of lesions in the nervous system in hypernatremic states. II. Experimental studies of gross anatomic changes and alterations of chemical composition of the tissues.

  1959cited by this paper
• Hemorrhagic encephalopathy induced by hypernatremia. II. Experimental observations on hyperosmolarity in cats.

  1959cited by this paper
• THE ACUTE EFFECTS IN MAN OF RAPID INTRAVENOUS INFUSION OF HYPERTONIC SODIUM BICARBONATE SOLUTION: I. Changes in Acid-Base Balance and Distribution of the Excess Buffer Base

  1955cited by this paper

• A comparison of traditional and quantitative analysis of acid-base and electrolyte imbalance in 87 cats

  2021cites this paper
• Administration of Sodium Bicarbonate

  2018cites this paper
• Characteristics, risk factors and management programs for vitality of newborn dairy calves

  2014cites this paper
• Comparative accuracy of several published formulae for the estimation of serum osmolality in cats.

  2013cites this paper
• Chapter 5 – Disorders of Potassium: Hypokalemia and Hyperkalemia

  2012cites this paper
• Plasma Osmolality Reference Values in African Grey Parrots (Psittacus erithacus erithacus), Hispaniolan Amazon Parrots (Amazona ventralis), and Red-fronted Macaws (Ara rubrogenys)

  2011cites this paper
• BOX 4-3 Causes of Corrected Hyperchloremia

  2011cites this paper
• Hyponatremia

  2010cites this paper
• Diabetic emergencies in small animals.

  2010cites this paper
• Determinination of plasma osmolality and agreement between measured and calculated values in healthy adult Hispaniolan Amazon parrots (Amazona ventralis).

  2009cites this paper
• Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis.

  2007cites this paper
• Chapter 9 – Introduction to Acid-Base Disorders

  2006cites this paper
• Chapter 1 – Applied Physiology of Body Fluids in Dogs and Cats

  2006cites this paper
• Chapter 4 – Disorders of Chloride: Hyperchloremia and Hypochloremia

  2006cites this paper
• Chapter 3 – Disorders of Sodium and Water: Hypernatremia and Hyponatremia

  2006cites this paper
• Chapter 10 – Metabolic Acid-Base Disorders

  2006cites this paper
• Chapter 5 – Disorders of Potassium: Hypokalemia and Hyperkalemia

  2006cites this paper
• Effects of intravenous hyperosmotic sodium bicarbonate on arterial and cerebrospinal fluid acid-base status and cardiovascular function in calves with experimentally induced respiratory and strong ion acidosis.

  2005cites this paper
• Carbohydrate malabsorption is a feature of feline inflammatory bowel disease but does not increase clinical gastrointestinal signs.

  2004cites this paper
• Hyponatremia.

  1998cites this paper