Genetic Diversity of Avian Influenza A (H10N8) Virus in Live Poultry Markets and Its Association with Human Infections in China

Following the first human infection with the influenza A (H10N8) virus in Nanchang, China in December 2013, we identified two additional patients on January 19 and February 9, 2014. The epidemiologic, clinical and virological data from the patients and the environmental specimen collected from 23 local live poultry markets (LPMs) were analyzed. The three H10N8 cases had a history of poultry exposure and presented with high fever (>38°C), rapidly progressive pneumonia and lymphopenia. Substantial high levels of cytokines and chemokines were observed. The sequences from an isolate (A/Environment/Jiangxi/03489/2013 [H10N8]) in an epidemiologically linked LPM showed highly identity with human H10N8 virus, evidencing LPM as the source of human infection. The HA and NA of human and environmental H10N8 isolates showed high identity (99.1–99.9%) while six genotypes with internal genes derived from H9N2, H7N3 and H7N9 subtype viruses were detected in environmental H10N8 isolates. The genotype of the virus causing human infection, Jiangxi/346, possessed a whole internal gene set of the A/Environment/Jiangxi/10618/2014(H9N2)-like virus. Thus, our findings support the notion that LPMs can act as both a gene pool for the generation of novel reassortants and a source for human infection and intensive surveillance and management should therefore be conducted.

• Publication year

  2015

• Venue

  Scientific Reports

• Publication date

  2015-01-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/srep07632PMID 25591167PMCID 5379002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genesis of the novel human-infecting influenza A(H10N8) virus and potential genetic diversity of the virus in poultry, China.

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• The dysfunctional host response to influenza A H7N9: a potential treatment option?

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• Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

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• Receptor binding by H10 influenza viruses

  2014cited by this paper
• Human infection with a novel avian-origin influenza A (H7N9) virus.

  2013cited by this paper
• Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome

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• Clinical findings in 111 cases of influenza A (H7N9) virus infection.

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• Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice

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• Human infection with avian influenza A H6N1 virus: an epidemiological analysis

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  2012cited by this paper
• Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China.

  2011cited by this paper
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  2011cited by this paper
• Oral and Poster Manuscripts

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• Genotypic evolution and antigenic drift of H9N2 influenza viruses in China from 1994 to 2008.

  2010cited by this paper
• Diversified reassortant H9N2 avian influenza viruses in chicken flocks in northern and eastern China.

  2010cited by this paper
• Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

  2006cited by this paper
• Continuing Evolution of H9N2 Influenza Viruses in Southeastern China

  2004cited by this paper
• Influenza surveillance in birds in Italian wetlands (1992-1998): is there a host restricted circulation of influenza viruses in sympatric ducks and coots?

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• The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye’s syndrome

  1999influential reference
• Human infection with influenza H9N2.

  1999cited by this paper
• Health Care Worker Incidents Reported in a Rural Health Care Facility

  1996cited by this paper
• The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype).

  1982cited by this paper
• Emerging Blockininfectious Blockindiseases Blockin@bullet Blockin Mutations of Novel Influenza A(h10n8) Virus in Chicken Eggs and Mdck Cells

  year unknowncited by this paper

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• Development of a multiplex and universal RT-PCR assay for hemagglutinin and neuraminidase subtyping of avian influenza virus

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• KRT10 plays an important role in the release of viral genome from endosomes during H9N2 subtype AIV replication in HeLa cells.

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• Immune Control of Avian Influenza Virus Infection and Its Vaccine Development

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• The multiple streams framework in a nondemocracy: The infeasibility of a national ban on live poultry sales in China

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• Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central China

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• Detection of novel reassortant H9N2 avian influenza viruses in wild birds in Jiangxi Province, China

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• Zoonotic Potential of Currently Circulating Avian Influenza Viruses

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• Species-Specific Host-Virus Interactions: Implications for Viral Host Range and Virulence.

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• Recombinant Lactococcus Lactis Expressing M1-HA2 Fusion Protein Provides Protective Mucosal Immunity Against H9N2 Avian Influenza Virus in Chickens

  2020cites this paper
• Isolation of two novel reassortant H3N6 avian influenza viruses from long‐distance migratory birds in Jiangxi Province, China

  2020cites this paper
• Profile and generation of reduced neuraminidase inhibitor susceptibility in highly pathogenic avian influenza H7N9 virus from human cases in Mainland of China, 2016-2019.

  2020cites this paper
• Duck-origin H5N6 avian influenza viruses induce different pathogenic and inflammatory effects in mice.

  2020cites this paper
• Distribution of Avian Influenza A Viruses in Poultry-Related Environment and Its Association with Human Infection in Henan, 2016 to 2017.

  2019cites this paper
• Emerging respiratory infections threatening public health in the Asia‐Pacific region: A position paper of the Asian Pacific Society of Respirology†

  2019cites this paper
• Animal Influenza Virus Infections in Humans: A Commentary.

  2019cites this paper
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• Avian influenza viruses in humans: lessons from past outbreaks.

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• ANIMAL INFLUENZA OUTBREAKS IN CROATIA : A SHORT REVIEW TO MARK THE CENTENARY OF THE 1918 INFLUENZA PANDEMIC

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• Human infection with a further evolved avian H9N2 influenza A virus in Sichuan, China

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• Emergence and development of H7N9 influenza viruses in China.

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  2016cites this paper
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• Endemic Variation of H9N2 Avian Influenza Virus in China

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• High Pathogenicity of Influenza A (H10N8) Virus in Mice.

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• Epidemiology, Evolution, and Recent Outbreaks of Avian Influenza Virus in China

  2015influential citation
• A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors.

  2015cites this paper
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