Up-Regulation of Stearoyl-CoA Desaturase 1 Increases Liver MUFA Content in Obese Zucker but Not Goto-Kakizaki Rats

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Lipids

• Publication date

  2013-03-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s11745-013-3786-2PMID 23539346
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice[S]

  2013cited by this paper
• Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice

  2012cited by this paper
• Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome.

  2012influential reference
• Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats.

  2012cited by this paper
• Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats.

  2012cited by this paper
• Diet modification and its influence on metabolic and related pathological alterations in the SHR/NDmcr-cp rat, an animal model of the metabolic syndrome.

  2012cited by this paper
• The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.

  2011cited by this paper
• Fatty acid regulation of hepatic lipid metabolism

  2011cited by this paper
• Differential fatty acid profile in adipose and non-adipose tissues in obese mice.

  2010cited by this paper
• Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response*

  2010cited by this paper
• Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis.

  2010cited by this paper
• A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats[S]

  2010cited by this paper
• Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.

  2010cited by this paper
• Genetic control of de novo lipogenesis: role in diet-induced obesity

  2010cited by this paper
• The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.

  2010influential reference
• Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective.

  2010cited by this paper
• Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species[S]

  2010cited by this paper
• Music Alive! in the Yakima Valley.

  2010cited by this paper
• Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C2C12 myotubes

  2009cited by this paper
• Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

  2009cited by this paper
• Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells

  2009cited by this paper
• Elovl6: a new player in fatty acid metabolism and insulin sensitivity

  2009cited by this paper
• Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

  2009cited by this paper
• Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes.

  2009cited by this paper
• Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

  2009cited by this paper
• Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

  2008cited by this paper
• Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans

  2008cited by this paper
• Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step*

  2008cited by this paper
• Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents.

  2008cited by this paper
• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

  2007cited by this paper
• Rimonabant reduces obesity‐associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

  2007cited by this paper
• Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.

  2007cited by this paper
• Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats.

  2007influential reference
• Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

  2006cited by this paper
• Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis*

  2006cited by this paper
• Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity Published, JLR Papers in Press, June 21, 2006.

  2006cited by this paper
• Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.

  2006cited by this paper
• Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases Published, JLR Papers in Press, January 16, 2005. DOI 10.1194/jlr.M400335-JLR200

  2005cited by this paper
• Programmed disorders of β‐cell development and function as one cause for type 2 diabetes? The GK rat paradigm

  2005cited by this paper
• Regulation of stearoyl-CoA desaturases and role in metabolism.

  2004influential reference
• Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  2004cited by this paper
• Triglyceride accumulation protects against fatty acid-induced lipotoxicity

  2003cited by this paper
• Regulation by carbohydrate and clofibric acid of palmitoyl-CoA chain elongation in the liver of rats

  2003influential reference
• Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements*

  2002cited by this paper
• The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1*

  2000cited by this paper
• Inhibiting delta9-desaturase activity impairs triacylglycerol secretion in cultured chicken hepatocytes.

  1997influential reference
• Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.

  1996cited by this paper
• Leptin receptor missense mutation in the fatty Zucker rat

  1996cited by this paper
• Increased proportion of plasma apoB-48 to apoB-100 in non-insulin-dependent diabetic rats: contribution of enhanced apoB mRNA editing in the liver.

  1995cited by this paper
• Obese Zucker (fa/fa) rats are resistant to insulin's inhibitory effect on hepatic apo B secretion.

  1994cited by this paper
• Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver.

  1993cited by this paper
• β-Cell Insensitivity to Glucose in the GK Rat, a Spontaneous Nonobese Model for Type II Diabetes

  1991cited by this paper
• Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.

  1991influential reference
• Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes.

  1991cited by this paper
• Δ6 and Δ5 desaturase activities in liver from obese zucker rats at different ages

  1989cited by this paper
• Delta 6 and delta 5 desaturase activities in liver from obese Zucker rats at different ages.

  1989cited by this paper
• Regulation of palmitoyl-CoA chain elongation and linoleoyl-CoA chain elongation in rat liver microsomes and the differential effects of peroxisome proliferators, insulin and thyroid hormone.

  1985cited by this paper
• In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats.

  1983cited by this paper
• Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid.

  1982cited by this paper
• Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid.

  1982influential reference
• Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats

  1975cited by this paper
• The preferred metabolic pathway from linoleic acid to arachidonic acid in vitro.

  1968cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Dietary Oleic Acid and SCD16 and ELOVL6 Estimated Activities Can Modify Erythrocyte Membrane n-3 and n-6 HUFA Partition: A Pilot Study

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  2023cites this paper
• Dietary Fat and Polyunsaturated Fatty Acid Intakes during Childhood Are Prospectively Associated with Puberty Timing Independent of Dietary Protein

  2022cites this paper
• Clofibric acid increases molecular species of phosphatidylethanolamine containing arachidonic acid for biogenesis of peroxisomal membranes in peroxisome proliferation in the liver.

  2021cites this paper
• A single pretreatment with clofibric acid attenuates carbon tetrachloride-induced necrosis, but not steatosis, in rat liver.

  2020cites this paper
• Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)

  2019cites this paper
• Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model

  2019cites this paper
• Genetic Variability in the Loci of FABP4, PPARγ and SCD Genes of Sheep Breeds Raised for Different Purposes

  2019cites this paper
• Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia

  2018cites this paper
• Effects of Methanolic Leaf Extract of Clinacanthus nutans on Fatty Acid Composition and Gene Expression in Male Obese Mice

  2018cites this paper
• Estratégias para as opções dietéticas de combate à obesidade relacionadas com a morbilidade cardiometabolica

  2017cites this paper
• Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs.

  2017cites this paper
• Abnormalities in the Metabolism of Fatty Acids and Triacylglycerols in the Liver of the Goto-Kakizaki Rat: A Model for Non-Obese Type 2 Diabetes

  2016influential citation
• DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs

  2016cites this paper
• Carrot Juice Administration Decreases Liver Stearoyl-CoA Desaturase 1 and Improves Docosahexaenoic Acid Levels, but Not Steatosis in High Fructose Diet-Fed Weanling Wistar Rats

  2016cites this paper
• Fatty Acid β-Oxidation Plays a Key Role in Regulating cis-Palmitoleic Acid Levels in the Liver.

  2016cites this paper
• Effects of dietary fi sh oil on cytochrome P 450 3 A expression in the liver of SHR / NDmcr-cp ( cp / cp ) rats , an animal model for metabolic syndrome

  2015cites this paper
• Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model for metabolic syndrome

  2015cites this paper
• Desaturaza stearylo-CoA – regulator metabolizmu lipidów Stearoyl-CoA desaturase – the lipid metabolism regulator

  2014cites this paper
• Effect of egg white and its hydrolysate on stearoyl-CoA desaturase index and fat accumulation in rat tissues

  2014cites this paper
• Increased muscular triglyceride content and hyperglycemia in Goto-Kakizaki rat are decreased by egg white hydrolysate

  2014influential citation
• [Stearoyl-CoA desaturase--the lipid metabolism regulator].

  2014cites this paper
• Inducing Effect of Clofibric Acid on Stearoyl-CoA Desaturase in Intestinal Mucosa of Rats

  2014cites this paper
• Fibrates reduce triacylglycerol content by upregulating adipose triglyceride lipase in the liver of rats.

  2013cites this paper
• Increased Lipid Synthesis and Decreased β-Oxidation in the Liver of SHR/NDmcr-cp (cp/cp) Rats, an Animal Model of Metabolic Syndrome

  2013influential citation