Use of the bovine model of tuberculosis for the development of improved vaccines and diagnostics.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Tuberculosis

• Publication date

  2003-02-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1016/S1472-9792(02)00062-8PMID 12758201
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A new evolutionary scenario for the Mycobacterium tuberculosis complex

  2002cited by this paper
• Identification of Novel Mycobacterium tuberculosis Antigens with Potential as Diagnostic Reagents or Subunit Vaccine Candidates by Comparative Genomics

  2002cited by this paper
• Correlation of ESAT-6-Specific Gamma Interferon Production with Pathology in Cattle following Mycobacterium bovis BCG Vaccination against Experimental Bovine Tuberculosis

  2002cited by this paper
• Conclusive Evidence That the Major T-cell Antigens of theMycobacterium tuberculosis Complex ESAT-6 and CFP-10 Form a Tight, 1:1 Complex and Characterization of the Structural Properties of ESAT-6, CFP-10, and the ESAT-6·CFP-10 Complex

  2002cited by this paper
• Influence of sensitisation to environmental mycobacteria on subsequent vaccination against bovine tuberculosis.

  2002cited by this paper
• Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle

  2002cited by this paper
• Immune Responses to the Mycobacterium tuberculosis-Specific Antigen ESAT-6 Signal Subclinical Infection among Contacts of Tuberculosis Patients

  2002cited by this paper
• Effect of different adjuvants on the immune responses of cattle vaccinated with Mycobacterium tuberculosis culture filtrate proteins.

  2002cited by this paper
• Failure of the Mycobacterium bovis BCG Vaccine: Some Species of Environmental Mycobacteria Block Multiplication of BCG and Induction of Protective Immunity to Tuberculosis

  2002cited by this paper
• Priming by DNA Immunization Augments Protective Efficacy of Mycobacterium bovis Bacille Calmette-Guerin against Tuberculosis

  2001cited by this paper
• Use of Synthetic Peptides Derived from the Antigens ESAT-6 and CFP-10 for Differential Diagnosis of Bovine Tuberculosis in Cattle

  2001cited by this paper
• Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.

  2001cited by this paper
• Mycobacterium bovis infection in human beings.

  2001cited by this paper
• Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of Treatment1

  2001cited by this paper
• A coordinated strategy for evaluating new vaccines for human and animal tuberculosis.

  2001cited by this paper
• Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians.

  2001cited by this paper
• Tuberculosis Contacts but Not Patients Have Higher Gamma Interferon Responses to ESAT-6 than Do Community Controls in The Gambia

  2001cited by this paper
• Use of ESAT-6 in the interferon-gamma test for diagnosis of bovine tuberculosis following skin testing.

  2001cited by this paper
• Enhanced Immunogenicity of CD4+ T-Cell Responses and Protective Efficacy of a DNA-Modified Vaccinia Virus Ankara Prime-Boost Vaccination Regimen for Murine Tuberculosis

  2001cited by this paper
• Comparative Evaluation of Low-Molecular-Mass Proteins fromMycobacterium tuberculosis Identifies Members of the ESAT-6 Family as Immunodominant T-Cell Antigens

  2000cited by this paper
• Effective DNA vaccination of cattle with the mycobacterial antigens MPB83 and MPB70 does not compromise the specificity of the comparative intradermal tuberculin skin test.

  2000cited by this paper
• Cattle-to-cattle transmission of bovine tuberculosis.

  2000cited by this paper
• Antigenic Equivalence of Human T-Cell Responses toMycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic Peptides

  2000cited by this paper
• Toward the development of diagnostic assays to discriminate between Mycobacterium bovis infection and bacille Calmette-Guérin vaccination in cattle.

  2000cited by this paper
• Increased Numbers of ESAT-6- and Purified Protein Derivative-Specific Gamma Interferon-Producing Cells in Subclinical and Active Tuberculosis Infection

  2000cited by this paper
• Diagnosis of Tuberculosis Based on the Two Specific Antigens ESAT-6 and CFP10

  2000cited by this paper
• Assessment of defined antigens for the diagnosis of bovine tuberculosis in skin test-reactor cattle

  2000cited by this paper
• Vaccination of Cattle with Mycobacterium bovis Culture Filtrate Proteins and Interleukin-2 for Protection against Bovine Tuberculosis

  2000cited by this paper
• Development of Diagnostic Reagents To Differentiate between Mycobacterium bovis BCG Vaccination and M. bovis Infection in Cattle

  1999cited by this paper
• Comparative genomics of BCG vaccines by whole-genome DNA microarray.

  1999cited by this paper
• Tuberculin-Purified Protein Derivative-, MPT-64-, and ESAT-6-Stimulated Gamma Interferon Responses in Medical Students before and after Mycobacterium bovis BCG Vaccination and in Patients with Tuberculosis

  1999cited by this paper
• Differentiation between Mycobacterium bovis BCG-Vaccinated and M. bovis-Infected Cattle by Using Recombinant Mycobacterial Antigens

  1999cited by this paper
• Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis.

  1999cited by this paper
• Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis

  1998cited by this paper
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

  1998cited by this paper
• The effect of heterologous immunity upon the apparent efficacy of (e.g. BCG) vaccines.

  1998cited by this paper
• Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors

  1998cited by this paper
• A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10).

  1998cited by this paper
• Recognition of a common mycobacterial T‐cell epitope in MPB59 of Mycobacterium bovis

  1998cited by this paper
• Erratum: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

  1998cited by this paper
• T‐Cell Recognition of Mycobacterial Proteins MPB70 and MPB64 in Cattle Immunized with Antigen and Infected with Mycobacterium bovis

  1998cited by this paper
• Effective, Nonsensitizing Vaccination with Culture Filtrate Proteins against Virulent Mycobacterium bovis Infections in Mice

  1998cited by this paper
• Protection Against Tuberculosis by Plasmid DNA

  1997cited by this paper
• The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis.

  1997cited by this paper
• Predominant recognition of the ESAT-6 protein in the first phase of interferon with Mycobacterium bovis in cattle

  1997cited by this paper
• Protection against tuberculosis by a plasmid DNA vaccine.

  1997cited by this paper
• Variation in protection by BCG

  1996cited by this paper
• Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis

  1996cited by this paper
• Heterogenous Expression of the Related MBP70 and MPB83 Proteins Distinguish Various Substrains of Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv

  1996cited by this paper
• Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG

  1996cited by this paper
• Auxotrophic vaccines for tuberculosis

  1996cited by this paper
• Immunological responses and protection against Mycobacterium bovis in calves vaccinated with a low dose of BCG.

  1995cited by this paper
• Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis

  1995cited by this paper
• Peptide Mapping of Bovine T‐Cell Epitopes for the 38 kDa Tuberculosis Antigen

  1995cited by this paper
• Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis

  1995cited by this paper
• Variation in protection by BCG: implications of and for heterologous immunity.

  1995cited by this paper
• Protection of cattle from bovine tuberculosis by vaccination with BCG by the respiratory or subcutaneous route, but not by vaccination with killed Mycobacterium vaccae.

  1995cited by this paper
• Epidemiology of Mycobacterium bovis infection in animals and humans, with particular reference to Africa.

  1995cited by this paper
• In vitro immunodiagnostic assays for bovine tuberculosis.

  1994cited by this paper
• Experimental Mycobacterium bovis infection in the brushtail possum (Trichosurus vulpecula): pathology, haematology and lymphocyte stimulation responses.

  1994cited by this paper
• Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins

  1994cited by this paper
• Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19,000 MW and MPB57.

  1994cited by this paper
• The BCG Experience: Implications for Future Vaccines against Tuberculosis

  1994cited by this paper
• Tuberculosis Pathogenesis, Protection, and Control

  1994cited by this paper
• Mycobacterium vaccae in immunoprophylaxis and immunotherapy of leprosy and tuberculosis.

  1990cited by this paper
• Field experiment with BCG vaccine in Malawi.

  1981cited by this paper
• Badgers, Cattle and Tuberculosis

  1980cited by this paper
• Incidence of tuberculosis in BCG vaccinated and control cattle in relation to age distribution in Malawi.

  1977cited by this paper
• Valeurs comparées du BCG vivant ou tué et du bacille de Koch trypsiné dans l'immunisation des zébus contre la tuberculose

  1975cited by this paper
• A second experiment to challenge the resistance to tuberculosis in B.C.G. vaccinated cattle in Malawi.

  1972cited by this paper
• An experiment to challenge the resistance to tuberculosis in B.C.G. vaccinated cattle in Malawi.

  1972cited by this paper
• Vaccination of Cattle with B.C.G.

  1958cited by this paper
• Studies on the vaccination of cattle as a measure against infection with tuberculosis with the living vole acid-fast bacillus

  1949cited by this paper
• Studies on the vaccination of cattle as a measure against infection with tuberculosis with the living vole acid-fast bacillus.

  1949cited by this paper
• Tuberculosis in Man and Animals.

  1936cited by this paper
• Vaccination of Calves against Tuberculosis with Calmette-Guérin Culture, BCG.

  1930cited by this paper
• The Prevention of Tuberculosis in Cattle

  1921cited by this paper
• The combating of tuberculosis in the light of the experience that has been gained in the successful combating of other infectious diseases

  1900cited by this paper
• Experiments Regarding the Vaccination of Cattle Against Tuberculosis by the Intravenous Injection of Tubercle Bacilli of the Human and Avian Types

  year unknowncited by this paper
• Five Years' Experience of Protective Inoculation against Tuberculosis in Cattle by Von Behring's Method

  year unknowncited by this paper

• The Impact of Animal Models and Strain Standardization on the Evaluation of Tuberculosis Vaccine Efficacy

  2025cites this paper
• Bovine NMRAL2 Protein Blunts Nitric Oxide Production and Inflammatory Response in Mycobacterium bovis Infected Bovine Lung Epithelial Cells

  2024cites this paper
• Vaccination Strategies in a Potential Use of the Vaccine against Bovine Tuberculosis in Infected Herds

  2022cites this paper
• Vaccination of Calves with the Mycobacterium bovis BCG Strain Induces Protection against Bovine Tuberculosis in Dairy Herds under a Natural Transmission Setting

  2022cites this paper
• The contribution of bovines to human health against viral infections

  2021influential citation
• Comparative proteomics identified immune response proteins involved in response to vaccination with heat-inactivated Mycobacterium bovis and mycobacterial challenge in cattle.

  2018cites this paper
• Immune response profiles of calves following vaccination with live BCG and inactivated Mycobacterium bovis vaccine candidates

  2017cites this paper
• Vaccination of calves with Mycobacterium bovis Bacillus Calmette–Guerin reduces the frequency and severity of lesions of bovine tuberculosis under a natural transmission setting in Ethiopia

  2017cites this paper
• The role of lung tissue-resident memory T cells in protection against tuberculosis

  2017cites this paper
• Stable expression of Mycobacterium bovis antigen 85B in auxotrophic M. bovis bacillus Calmette-Guérin

  2017cites this paper
• Applying the One Health Concept to Mycobacterial Research – Overcoming Parochialism

  2017cites this paper
• Mycobacterium bovis Infection of Cattle and White-Tailed Deer: Translational Research of Relevance to Human Tuberculosis.

  2015cites this paper
• Pathology of bovine tuberculosis.

  2014cites this paper
• BCG Δzmp1 vaccine induces enhanced antigen specific immune responses in cattle.

  2014cites this paper
• DEVELOPMENT OF CATTLE TB VACCINES

  2014cites this paper
• Relevance of bovine tuberculosis research to the understanding of human disease: historical perspectives, approaches, and immunologic mechanisms.

  2014cites this paper
• A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

  2013cites this paper
• Evaluation of attenuated bovine farcy vaccine ; M . farcinogenes in zebu calves using serology , passive immunization and Plaque forming Cell Assay , Sudan

  2013cites this paper
• Inhaled Vaccines for the Prevention of Tuberculosis

  2013cites this paper
• Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A.

  2012cites this paper
• Identification of biomarkers in protection against bovine tuberculosis through global gene expression analysis in vaccinated and infected mice and cattle

  2012cites this paper
• Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes

  2012cites this paper
• Global Gene Transcriptome Analysis in Vaccinated Cattle Revealed a Dominant Role of IL-22 for Protection against Bovine Tuberculosis

  2012cites this paper
• Progress in Oral Vaccination against Tuberculosis in Its Main Wildlife Reservoir in Iberia, the Eurasian Wild Boar

  2012cites this paper
• Inhaled Vaccines for the Prevention of Tuberculosis

  2012cites this paper
• Tuberculosis vaccines in clinical trials

  2011cites this paper
• New Generation BCG Vaccines

  2011cites this paper
• Expression and Immunogenicity of the Mycobacterial Ag85B/ESAT-6 Antigens Produced in Transgenic Plants by Elastin-Like Peptide Fusion Strategy

  2010cites this paper
• Molecular findings and approaches spotlighting Mycobacterium bovis persistence in cattle

  2009cites this paper
• Evaluación de diferentes inmunógenos contra la tuberculosis bovina mediante la presencia de lesiones a la necropsia Evaluation of different immunogens against bovine tuberculosis based on presence of lesions at necropsy

  2009cites this paper
• Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1.

  2009cites this paper
• Evaluación de diferentes inmunógenos contrala tuberculosis bovina mediante la presenciade lesiones a la necropsia

  2009cites this paper
• The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+gamma/deltaTCR-CD45RO+ T-cell population.

  2009cites this paper
• TUBERCULOSIS IN EUROPEAN BADGERS (MELES MELES) AND THE CONTROL OF INFECTION WITH BACILLE CALMETTE-GUÉRIN VACCINATION

  2009cites this paper
• Identification of Proteins from Tuberculin Purified Protein Derivative (PPD) with Potential for TB Diagnosis Using Bioinformatics Analysis

  2009cites this paper
• Identification of proteins from tuberculin purified protein derivative (PPD) by LC-MS/MS.

  2009cites this paper
• Cytokine gene and protein expression in BCG vaccinated and non-vaccinated Mycobacterium bovis infected cattle

  2009influential citation
• Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis

  2009cites this paper
• Evidence for enhanced central memory priming by live Mycobacterium bovis BCG vaccine in comparison with killed BCG formulations.

  2008cites this paper
• Bovine TB and the development of new vaccines.

  2008cites this paper
• Development of a Mycobacterium bovis intranasal challenge model in mice.

  2008cites this paper
• Confronting the scientific obstacles to global control of tuberculosis.

  2008cites this paper
• What animal models teach humans about tuberculosis.

  2008cites this paper
• Experimental tuberculosis in the European badger (Meles meles) after endobronchial inoculation with Mycobacterium bovis: II. Progression of infection.

  2008cites this paper
• Consequence of prior exposure to environmental mycobacteria on BCG vaccination and diagnosis of tuberculosis infection.

  2008cites this paper
• Bovine natural killer cells restrict the replication of Mycobacterium bovis in bovine macrophages and enhance IL-12 release by infected macrophages.

  2007cites this paper
• Mycobacterium bovis DeltaleuD auxotroph-induced protective immunity against tissue colonization, burden and distribution in cattle intranasally challenged with Mycobacterium bovis Ravenel S.

  2007cites this paper
• Translational Mini‐Review Series on Vaccines:
Development and evaluation of improved vaccines against tuberculosis

  2007cites this paper
• Animal models of cavitation in pulmonary tuberculosis.

  2006cites this paper
• Pathogenesis of bovine tuberculosis: the role of experimental models of infection.

  2006cites this paper
• Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle.

  2006cites this paper
• Immunohistochemical markers augment evaluation of vaccine efficacy and disease severity in bacillus Calmette-Guerin (BCG) vaccinated cattle challenged with Mycobacterium bovis.

  2006cites this paper
• The safety and immunogenicity of Bacillus Calmette-Guérin (BCG) vaccine in European badgers (Meles meles).

  2006cites this paper
• Protective efficacy induced by Mycobacterium bovis bacille Calmette-Guèrin can be augmented in an antigen independent manner by use of non-coding plasmid DNA.

  2006cites this paper
• A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG.

  2006cites this paper
• Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85A and Mycobacterium bovis BCG

  2006cites this paper
• Development of vaccines against bovine tuberculosis

  2006cites this paper
• Immunogenicity of Mycobacterium tuberculosis Antigens in Mycobacterium bovis BCG-Vaccinated and M. bovis-Infected Cattle

  2006cites this paper
• Development of cattle TB vaccines in the UK.

  2006cites this paper
• Infection Biology of a Novel α-Crystallin of Mycobacterium tuberculosis: Acr21

  2005cites this paper
• Synthetic peptide vaccination in cattle: induction of strong cellular immune responses against peptides derived from the Mycobacterium bovis antigen Rv3019c.

  2005cites this paper
• Mutation in the P36 gene of Mycobacterium bovis provokes attenuation of the bacillus in a mouse model.

  2005cites this paper
• Frequency of IFN-gamma producing cells correlates with adjuvant enhancement of bacille Calmette-Guèrin induced protection against Mycobacterium bovis.

  2005cites this paper
• Protective immunity against Mycobacterium bovis induced by vaccination with Rv3109c--a member of the esat-6 gene family.

  2005cites this paper
• The use of animal models to guide rational vaccine design.

  2005cites this paper
• Vaccines for bovine tuberculosis: current views and future prospects

  2005cites this paper
• Exposure to Mycobacterium avium induces low‐level protection from Mycobacterium bovis infection but compromises diagnosis of disease in cattle

  2005cites this paper
• Cattle as a model for development of vaccines against human tuberculosis.

  2005cites this paper
• Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis

  2005cites this paper
• Development of an adult-like cell-mediated immune response in calves after early vaccination with Mycobacterium bovis bacillus Calmette-Guérin.

  2005cites this paper
• Vaccination of brushtail possums, Trichosurus vulpecula, with Bacille Calmette–Guerin induces T lymphocytes that reduce Mycobacterium bovis replication in alveolar macrophages via a contact‐dependent/nitric oxide‐independent mechanism

  2005cites this paper
• Recognition of Mycobacterial Antigens Delivered by Genetically Detoxified Bordetella pertussis Adenylate Cyclase by T Cells from Cattle with Bovine Tuberculosis

  2004cites this paper
• Association of Tuberculin-Boosted Antibody Responses with Pathology and Cell-Mediated Immunity in Cattle Vaccinated with Mycobacterium bovis BCG and Infected with M. bovis

  2004cites this paper
• Cellular immune responses induced in cattle by heterologous prime–boost vaccination using recombinant viruses and bacille Calmette–Guérin

  2004cites this paper
• Evaluation of T-Cell Responses to Novel RD1- and RD2-Encoded Mycobacterium tuberculosis Gene Products for Specific Detection of Human Tuberculosis Infection

  2004influential citation
• Cytotoxic T‐cell responses to Mycobacterium bovis during experimental infection of cattle with bovine tuberculosis

  2003cites this paper
• A DNA Prime-Mycobacterium bovis BCG Boost Vaccination Strategy for Cattle Induces Protection against Bovine Tuberculosis

  2003cites this paper
• Revaccination of Neonatal Calves with Mycobacterium bovis BCG Reduces the Level of Protection against Bovine Tuberculosis Induced by a Single Vaccination

  2003cites this paper