ResearchGenetic evidence that SMAD 2 is not required for gonadal tumor development in inhibin-deficient mice

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  2015

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• Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes

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• Redundant Roles of SMAD2 and SMAD3 in Ovarian Granulosa Cells In Vivo

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• Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein.

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• Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice

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• Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice.

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• Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery.

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• A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling

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• Intraovarian activins are required for female fertility.

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• Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms.

  2005cited by this paper
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  2005cited by this paper
• Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells.

  2005cited by this paper
• Granulosa cell-specific inactivation of follistatin causes female fertility defects.

  2004cited by this paper
• Generation of novel conditional and hypomorphic alleles of the Smad2 gene

  2004cited by this paper
• Smad2 and Smad3 coordinately regulate craniofacial and endodermal development.

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• Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin a: Comparison of a cholangiocarcinoma cell line with primary cultures of non‐neoplastic biliary epithelial cells

  2000cited by this paper
• Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice.

  2000cited by this paper
• Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.

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• A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3

  1999cited by this paper
• Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study.

  1999cited by this paper
• Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

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  1998cited by this paper
• Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

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  1998cited by this paper
• Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145.

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• IMMUNOHISTOCHEMICAL EXPRESSION OF INHIBIN/ACTIVIN SUBUNITS IN EPITHELIAL AND GRANULOSA CELL TUMOURS OF THE OVARY

  1997cited by this paper
• Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development.

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• Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice.

  1996cited by this paper
• Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.

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• Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation.

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• Development and application of a two-site enzyme immunoassay for the determination of 'total' activin-A concentrations in serum and follicular fluid.

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• Inhibin Antagonizes Inhibition of Liver Cell Growth by Activin by a Dominant-negative Mechanism (*)

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• Functional analysis of activins during mammalian development

  1995cited by this paper
• Overexpression of activin-beta A subunit mRNA is associated with decreased activin type II receptor mRNA levels in the testes of alpha-inhibin deficient mice.

  1994cited by this paper
• Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor.

  1994cited by this paper
• Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice.

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• Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

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• Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

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• Receptors for the TGF-beta family.

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• Activin-binding protein from rat ovary is follistatin.

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• Inhibin

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• Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone.

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• A homodimer of the beta-subunits of inhibin A stimulates the secretion of pituitary follicle stimulating hormone.

  1986cited by this paper
• Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

  1986cited by this paper

• No citing papers are available for this paper.