Myristic Acid Increases Dihydroceramide Δ4-Desaturase 1 (DES1) Activity in Cultured Rat Hepatocytes

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Lipids

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s11745-011-3638-xPMID 22139871
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide*

  2011cited by this paper
• Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

  2011cited by this paper
• Post-translational myristoylation: Fat matters in cellular life and death.

  2011cited by this paper
• Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations.

  2011cited by this paper
• Differential Regulation of Dihydroceramide Desaturase by Palmitate versus Monounsaturated Fatty Acids

  2011cited by this paper
• Dihydroceramide desaturase activity is modulated by oxidative stress.

  2010cited by this paper
• Short Chain Saturated Fatty Acids Decrease Circulating Cholesterol and Increase Tissue PUFA Content in the Rat

  2010cited by this paper
• [New regulatory and signal functions for myristic acid].

  2009cited by this paper
• N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid.

  2009cited by this paper
• Acide myristique : nouvelles fonctions de régulation et de signalisation

  2009cited by this paper
• Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

  2007cited by this paper
• Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells*

  2007cited by this paper
• Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.

  2007cited by this paper
• Ceramide and other sphingolipids in cellular responses

  2007cited by this paper
• Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation.

  2007cited by this paper
• In rat hepatocytes, myristic acid occurs through lipogenesis, palmitic acid shortening and lauric acid elongation.

  2007cited by this paper
• Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.

  2006cited by this paper
• Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.

  2006cited by this paper
• Mitochondrial Ceramide and the Induction of Apoptosis

  2005cited by this paper
• N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning

  2005cited by this paper
• Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons in liver cells

  2004cited by this paper
• MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

  2004cited by this paper
• Myristic acid increases delta6-desaturase activity in cultured rat hepatocytes.

  2004cited by this paper
• DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.

  2004cited by this paper
• Myristic acid increases Δ6-desaturase activity in cultured rat hepatocytes

  2004cited by this paper
• Although it is rapidly metabolized in cultured rat hepatocytes, lauric acid is used for protein acylation.

  2003cited by this paper
• Exogenous myristic acid acylates proteins in cultured rat hepatocytes.

  2002cited by this paper
• Akt Protein Kinase Inhibits Non-apoptotic Programmed Cell Death Induced by Ceramide*

  2002cited by this paper
• Identification and characterization of a sphingolipid delta 4-desaturase family.

  2002cited by this paper
• Identification and Characterization of a Sphingolipid Δ4-Desaturase Family*

  2002cited by this paper
• Ceramide in apoptosis signaling: relationship with oxidative stress.

  2001cited by this paper
• Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway*

  2001cited by this paper
• Myristic acid, unlike palmitic acid, is rapidly metabolized in cultured rat hepatocytes.

  2000cited by this paper
• Ceramide in the eukaryotic stress response.

  2000cited by this paper
• Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity

  2000influential reference
• Characterization of Ceramide Synthesis

  1997influential reference
• Conversion of dihydroceramide into ceramide: involvement of a desaturase.

  1997cited by this paper
• Role of nitric oxide in obesity-induced beta cell disease.

  1997cited by this paper
• Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

  1997cited by this paper
• A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes

  1996cited by this paper
• Sphingolipid Biosynthesis de Novo by Rat Hepatocytes in Culture.

  1995cited by this paper
• Genetic and biochemical studies of protein N-myristoylation.

  1994cited by this paper
• Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

  1993cited by this paper
• Programmed cell death induced by ceramide.

  1993cited by this paper
• Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase.

  1992cited by this paper
• The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue.

  1991cited by this paper
• Human cellular src gene product: identification of the myristoylated pp60c-src and blockage of its myristoyl acylation with N-fatty acyl compounds resulted in the suppression of colony formation.

  1990cited by this paper
• Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins.

  1989cited by this paper
• Stimulus-dependent myristoylation of a major substrate for protein kinase C

  1988cited by this paper
• Lysogangliosides: synthesis and use in preparing labeled gangliosides.

  1987cited by this paper
• Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain.

  1984cited by this paper
• In vivo modification of retroviral gag gene-encoded polyproteins by myristic acid

  1983cited by this paper
• Assay of proteins in the presence of interfering materials.

  1976cited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Sodium Palmitate Induces Partial Mitochondrial Uncoupling and Reactive Oxygen Species in Rat Pancreatic Islets in Vitro*

  year unknowncited by this paper

• Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis

  2025cites this paper
• A key sphingolipid pathway gene, MoDES1, regulates conidiation, virulence and plasma membrane tension in Magnaporthe oryzae.

  2023cites this paper
• Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

  2021cites this paper
• Mapping the myristoylome through a complete understanding of protein myristoylation biochemistry.

  2021cites this paper
• Inhibitors of dihydroceramide desaturase 1: Therapeutic agents and pharmacological tools to decipher the role of dihydroceramides in cell biology.

  2016cites this paper
• Lactosylceramide contributes to mitochondrial dysfunction in diabetes

  2016cites this paper
• Fatty acid acylation of proteins: specific roles for palmitic, myristic and caprylic acids

  2016cites this paper
• Acides gras saturés et acylation des protéines : des aspects fonctionnels à l’approche nutritionnelle

  2016cites this paper
• Specific roles of saturated fatty acids: Beyond epidemiological data

  2015cites this paper
• Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity.

  2015cites this paper
• Dihydroceramides: From Bit Players to Lead Actors*

  2015cites this paper
• Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (vtv) And Involved In The Biogenesis Of The Vtv

  2013cites this paper
• L’acylation des protéines : une fonction cellulaire importante des acides gras saturés

  2013cites this paper
• Protein N-Myristoylation Plays a Critical Role in the Endoplasmic Reticulum Morphological Change Induced by Overexpression of Protein Lunapark, an Integral Membrane Protein of the Endoplasmic Reticulum

  2013cites this paper