Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as a new class of anti-cancer agents.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  European journal of medicinal chemistry

• Publication date

  2011-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2011.07.045PMID 21862183
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis of dipeptidyl peptidase-4 inhibitors: a brief overview

  2010cited by this paper
• Recent advances in glucokinase activators for the treatment of type 2 diabetes.

  2009cited by this paper
• Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.

  2009cited by this paper
• Medicinal chemistry approaches for glucokinase activation to treat type 2 diabetes.

  2009cited by this paper
• Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes.

  2009cited by this paper
• Vanilloid receptor antagonists: emerging class of novel anti-inflammatory agents for pain management.

  2009cited by this paper
• HDL Therapeutics for the treatment of atherosclerosis: a brief overview of the synthetic approaches

  2009cited by this paper
• Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.

  2008cited by this paper
• HDL elevators and mimetics--emerging therapies for atherosclerosis.

  2007cited by this paper
• The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

  2006cited by this paper
• Global Cancer Statistics, 2002

  2005cited by this paper
• A rapid and direct access to symmetrical/unsymmetrical 3,4-diarylmaleimides and pyrrolin-2-ones

  2004cited by this paper
• A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C–C bond formation reaction

  2003cited by this paper
• BRAF as a potential therapeutic target in melanoma and other malignancies.

  2003cited by this paper
• IMPROVED METHOD FOR DEMETHYLATION OF NITRO- CATECHOL METHYL ETHERS

  2002cited by this paper
• Facile and Fast Pinacol Rearrangement by AlCl3 in the Solid State

  2001cited by this paper
• Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.

  2001cited by this paper
• Synthesis of C-C-bridged bis-isoflavones.

  2000cited by this paper
• Trifluoromethanesulfonic Acid Catalyzed Novel Friedel–Crafts Acylation of Aromatics with Methyl Benzoate

  2000cited by this paper
• A convenient strategy for the synthesis of 4,5-bis(o-haloaryl)isoxazoles

  2000cited by this paper
• Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.

  1999cited by this paper
• CLAY CATALIZED REARRANGEMENT OF PHENYLOXIRANES

  1997cited by this paper
• A novel and versatile synthesis of 1-aryl-benzocyclobutenols and 1-aryl-benzocyclobutenes

  1991cited by this paper
• Expedient synthesis of polyhydroxyisoflavones

  1991cited by this paper
• Facile synthesis of benzyl ketones by the reductive coupling of benzyl bromide and acyl chlorides in the presence of a palladium catalyst and zinc powder.

  1981cited by this paper
• Anodic oxidation of 1,2,3,4-tetrahydronaphthalene and isochroman analogs of 1-benzyl and 1-phenethyl isoquinoline alkaloids. Products and mechanism of the intramolecular cyclization

  1979cited by this paper
• α-Aminonitriles—I: A simple synthesis of deoxybenzoins

  1975cited by this paper

• Synthesis, Anticancer and EGFR Inhibitory Activity of Novel Benzo[b][1,4]oxazine-1,3,4-oxadiazolo-1,2,3-triazoles

  2025cites this paper
• Mechanistic Insights and Anti-cancer Activity of 2H-benzo[b][1,4]oxazin-3(4H)-one Linked 1,2,3-Triazoles in Human Cancer Cells

  2025cites this paper
• Efficient Scale-Up of Benzoxazinone Derivative-Deferasirox Intermediate Synthesis: A Study on Cyanuric Chloride as a Chlorinating Agent

  2025cites this paper
• Synthesis, Crystal Structure, DFT Studies, Hirshfeld Suface Analysis and Antitumor Activity of 4-(tert-Butyl)-5-(1,2,4-triazole-1-yl)thiazole Derivatives Containing Benzoxazinone

  2024cites this paper
• Synthesis, antiproliferative evaluation and in silico studies of a novel steroidal spiro morpholinone.

  2023cites this paper
• Novel (E)‐3‐(3‐Oxo‐4‐substituted‐3,4‐dihydro‐2H‐benzo[b][1,4]oxazin‐6‐yl)‐N‐hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis and Bioevaluation

  2023cites this paper
• Aerobic/Room‐Temperature‐Compatible s‐Block Organometallic Chemistry in Neat Conditions: A Missing Synthetic Tool for the Selective Conversion of Nitriles into Asymmetric Alcohols

  2022cites this paper
• Design, Synthesis, and Bioactivity of Eighteen Novel 2H‐1,4‐Benzoxazin‐3(4H)‐one Containing a Propanolamine Moiety

  2022cites this paper
• Recent development of imidazole derivatives as potential anticancer agents

  2022cites this paper
• Synthesis and anticancer, antidiabetic activity test of β-hydroxypicolinyl serine ethyl heptanoyl ester (PSEHE)

  2021cites this paper
• One-Pot Regioselective Synthesis of 7-Bromo-2H-Benzo[b][1,4]Oxazin-3(4H)-One Linked Isoxazole Hybrids as Anti-Cancer Agents and Their Molecular Docking Studies

  2021cites this paper
• Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions.

  2021cites this paper
• Intramolecular cyclization of N-hydroxy-2-phenoxyacetamides and 3-phenoxypropanamides

  2020cites this paper
• Anti-cancer activity of benzoxazinone derivatives via targeting c-Myc G-quadruplex structure.

  2020cites this paper
• Synthesis of hydroxy-containing terarylenes with pyrazole and allomaltol fragments

  2020cites this paper
• Synthesis of 4H-1,3-benzoxazin-4-ones from 2,2-diazidobenzofuran-3(2H)-ones

  2019cites this paper
• Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties

  2019cites this paper
• Synthesis of New Benzoxazinone, Quinazolinone, and Pyrazoloquinazolinone Derivatives and Evaluation of Their Cytotoxic Activity Against Human Breast Cancer Cells

  2018cites this paper
• N′‐[(E)‐Arylidene]‐2‐(2,3‐dihydro‐3‐oxo‐4H‐1,4‐benzoxazin‐4‐yl)‐acetohydrazides: Synthesis and Evaluation of Caspase Activation Activity and Cytotoxicity

  2018cites this paper
• Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents.

  2018cites this paper
• Regioselective synthesis of 3,4-diaryl-5-unsubstituted isoxazoles, analogues of natural cytostatic combretastatin A4.

  2018cites this paper
• BF3·OEt2‐Mediated Synthesis of 2‐Arylthio‐ and (N‐Aryl‐2,5‐dioxopyrrolidin‐3‐yl)‐Substituted 1,4‐Benzoxazine Derivatives

  2017cites this paper
• Synthesis and antiproliferative evaluation of new (4-substituted-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methane substituted sulfonamide derivatives

  2017cites this paper
• Efficient synthesis of benzene-fused 6/7-membered amides via Xphos Pd G2 catalyzed intramolecular C–N bond formation

  2017cites this paper
• Imidazoles as potential anticancer agents.

  2017cites this paper
• Synthesis and anti-proliferative activity of a small library of 7-substituted 5H-pyrrole [1,2-a][3,1]benzoxazin-5-one derivatives.

  2017cites this paper
• One-pot synthesis of fused benzoxazino[1,2,3]triazolyl[4,5-c]quinolinone derivatives and their anticancer activity

  2016cites this paper
• AlCl3-mediated heteroarylation-cyclization strategy: one-pot synthesis of fused quinoxalines containing the central core of Lamellarin D

  2016cites this paper
• A facile and efficient synthesis of 4H-1,3-benzoxazine-4-one with electron-withdrawing group derivatives

  2015cites this paper
• Erbium trifluoromethanesulfonate-catalyzed Friedel–Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation

  2015cites this paper
• A metal catalyst-free and one-pot synthesis of (3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol derivatives in water

  2015cites this paper
• Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth.

  2014cites this paper
• Reactions of salicylaldehydes with activated terminal alkynes in aqueous media: synthesis of 3-substituted 4-hydroxy chromenes as potential cytotoxic agents

  2014cites this paper
• Pd/C‐Mediated Alkynylation of Indazoles: Synthesis and Pharmacological Evaluation of Mono and Dialkynyl‐Substituted Indazoles

  2014cites this paper
• Comprehensive Review in Current Developments of Imidazole‐Based Medicinal Chemistry

  2014cites this paper
• H3PO4/(CF3CO)2O Mediated Acylation Followed by Hurd–Mori Reaction: Synthesis of Novel 1,2,3‐Thiadiazol Derivatives

  2013cites this paper
• Synthesis and Pharmacological Evaluations of Novel 2H-Benzo[b][1,4]oxazin-3(4H)-one Derivatives as a New Class of Anticancer Agents.

  2012cites this paper
• A new approach to construct a fused 2-ylidene chromene ring: highly regioselective synthesis of novel chromeno quinoxalines.

  2012cites this paper
• AlCl3 induced C–N bond formation followed by Pd/C–Cu mediated coupling–cyclization strategy: synthesis of pyrrolo[2,3-b]quinoxalines as anticancer agents

  2012cites this paper
• Medicinal Chemistry Research

  year unknowncites this paper