WT1基因rs16754多态性与急性髓系白血病患者临床特征及预后关系的研究

目的 探讨WT1基因rs16754多态性与急性髓系白血病(AML)患者临床特征及预后的关系。 方法 收集2010年1月至2013年12月山西医科大学第二临床医学院115例AML患者初诊时骨髓及177名健康体检者外周血样本，采用高分辨熔解曲线法(HRM)进行WT1基因rs16754多态性位点分型，并通过直接测序法验证，回顾性分析该位点单核苷酸多态性(SNP)与AML发病风险、患者临床特征、缓解及生存情况的相关性。 结果 WT1基因rs16754多态性与AML发病风险无关(P= 0.296)，GA/AA组与GG组在患者性别、年龄及临床各指标间及化疗缓解率上差异均无统计学意义(P值均>0.05)，GA/AA组骨髓原始细胞比例高于GG组(P=0.025)。随访99例患者生存情况，单因素分析发现GA/AA组总体生存率高于GG组(P=0.035)。多因素分析显示A等位基因是AML患者的独立预后因素，GA/AA型患者的死亡风险高于GG型患者(HR=1.681,95% CI 1.046~2.700，P=0.032)。 结论 WT1 rs16754多态性与AML预后有关，可作为AML患者预后判断的指标之一。

• Publication year

  2016

• Venue

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

• Publication date

  2016-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3760/cma.j.issn.0253-2727.2016.10.017PMID 27801325PMCID 7364874
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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