Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD

No abstract is available for this paper.

• Publication year

  2016

• Venue

  European Respiratory Journal

• Publication date

  2016-03-10

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1183/13993003.01080-2015PMID 26965288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Women and Lung Disease. Sex Differences and Global Health Disparities.

  2015cited by this paper
• Chronic Bronchitis and Current Smoking Are Associated with More Goblet Cells in Moderate to Severe COPD and Smokers without Airflow Obstruction

  2015cited by this paper
• Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?

  2014cited by this paper
• Distribution of T-cell subsets in BAL fluid of patients with mild to moderate COPD depends on current smoking status and not airway obstruction.

  2014cited by this paper
• Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

  2014cited by this paper
• Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study

  2014cited by this paper
• Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes

  2014cited by this paper
• Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers

  2014cited by this paper
• Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.

  2013cited by this paper
• Gender Differences in the Long-Chain Polyunsaturated Fatty Acid Status: Systematic Review of 51 Publications

  2013cited by this paper
• The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.

  2013cited by this paper
• Linoleic acid.

  2013cited by this paper
• Platelets in lung biology.

  2013cited by this paper
• Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease.

  2013cited by this paper
• The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor.

  2013cited by this paper
• Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects.

  2013cited by this paper
• Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine.

  2013cited by this paper
• Adhesion molecules in subjects with COPD and healthy non-smokers: a cross sectional parallel group study

  2013cited by this paper
• Gender differences in the bronchoalveolar lavage cell proteome of patients with chronic obstructive pulmonary disease.

  2013cited by this paper
• Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure.

  2012cited by this paper
• Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation

  2012cited by this paper
• Patient characteristics, treatment patterns, and health outcomes among COPD phenotypes

  2012cited by this paper
• Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

  2012cited by this paper
• Increased platelet activation in patients with stable and acute exacerbation of COPD

  2011cited by this paper
• Reconsidering sex-based stereotypes of COPD.

  2011cited by this paper
• Lipid mediator profiling in pulmonary disease.

  2011cited by this paper
• A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

  2010cited by this paper
• Gender differences in COPD: are women more susceptible to smoking effects than men?

  2010cited by this paper
• Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

  2009cited by this paper
• Statins in COPD: a systematic review.

  2009cited by this paper
• Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis.

  2009cited by this paper
• Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

  2009cited by this paper
• Sex differences in emphysema and airway disease in smokers.

  2009cited by this paper
• Endothelium-platelet interactions in inflammatory lung disease.

  2008cited by this paper
• Patients with Chronic Obstructive Pulmonary Disease

  2008cited by this paper
• Structural basis for the activation of PPARgamma by oxidized fatty acids.

  2008cited by this paper
• Structural Basis for the Activation of Pparg by Oxidised Fatty Acids

  2008cited by this paper
• The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism.

  2007cited by this paper
• Global burden of COPD: risk factors, prevalence, and future trends.

  2007cited by this paper
• Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst

  2007cited by this paper
• Gender and chronic obstructive pulmonary disease: why it matters.

  2007cited by this paper
• Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress.

  2007cited by this paper
• Selectins revisited: the emerging role of platelets in inflammatory lung disease.

  2006cited by this paper
• Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis

  2006cited by this paper
• Bronchoalveolar lavage in COPD: fluid recovery correlates with the degree of emphysema

  2005cited by this paper
• Epoxide hydrolases: their roles and interactions with lipid metabolism.

  2005cited by this paper
• Oxidative Stress Stimulates the Synthesis of the Eosinophil Chemoattractant 5-Oxo-6,8,11,14-eicosatetraenoic Acid by Inflammatory Cells*

  2004cited by this paper
• Burden and clinical features of chronic obstructive pulmonary disease (COPD).

  2004cited by this paper
• Mediators of Chronic Obstructive Pulmonary Disease

  2004cited by this paper
• Relationship of airway epithelial ion transport to chronic bronchitis.

  2004cited by this paper
• Leukotoxin-diol: a putative toxic mediator involved in acute respiratory distress syndrome.

  2001cited by this paper
• The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells.

  2001cited by this paper
• Leukotoxins and the lung.

  1999cited by this paper
• Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

  1997cited by this paper
• Airway hyperresponsiveness induced by 13-hydroxyoctadecadienoic acid (13-HODE) is mediated by sensory neuropeptides.

  1995cited by this paper
• Phorbol myristate acetate stimulates the formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human neutrophils by activating NADPH oxidase.

  1994cited by this paper
• The distribution of cytochrome P-450 monooxygenase in cells of the rabbit lung: an ultrastructural immunocytochemical characterization.

  1988cited by this paper
• Existence of leukotoxin 9,10-epoxy-12-octadecenoate in lung lavages from rats breathing pure oxygen and from patients with the adult respiratory distress syndrome.

  1988cited by this paper
• Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia.

  1986cited by this paper
• Neutrophils biosynthesize leukotoxin, 9, 10-epoxy-12-octadecenoate.

  1986cited by this paper
• Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway.

  1985cited by this paper
• Isolation and identification of two isomeric trihydroxy octadecenoic acids with prostaglandin E-like activity from onion bulbs (Allium cepa).

  1985cited by this paper

• Oxylipin Profiling of Airway Structural Cells Is Unique and Modified by Relevant Stimuli

  2025cites this paper
• The role of metabolomics in chronic obstructive pulmonary disease: from analytic techniques to clinical applications

  2025cites this paper
• Association between menopausal age and chronic obstructive pulmonary disease and the mediating role of smoking: a study based on NHANES 1999-2018.

  2025cites this paper
• The role of bioactive lipids and eicosanoid metabolites in acute exercise in adults: Insights into human cardiorespiratory fitness

  2025cites this paper
• Exploring the metabolomics and metagenomics of chronic obstructive pulmonary disease (COPD) and lung cancer: unraveling the complex interplay

  2025cites this paper
• Gender, tobacco and chronic obstructive pulmonary disease: analysis of the 2020 National Health Interview Survey

  2025cites this paper
• The G-protein coupled receptor OXER1 is a tissue redox sensor essential for intestinal epithelial barrier integrity

  2025cites this paper
• Exploring the Potential Role of Metabolomics in COPD: A Concise Review

  2024cites this paper
• The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi

  2024cites this paper
• Impact of Short-Term Diesel Exhaust Exposure on Prothrombotic Markers in COPD: A Randomized, Double-blinded, Crossover Study.

  2024cites this paper
• Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling

  2024cites this paper
• The Cytochrome P450 2C8*3 Variant (rs11572080) Is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells

  2024cites this paper
• Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the OXE Receptor in Allergic Diseases: Collegium Internationale Allergologicum Update 2024

  2024cites this paper
• Metabolomics in COPD.

  2023cites this paper
• Screening of Lipid Metabolism-Related Genes as Diagnostic Indicators in Chronic Obstructive Pulmonary Disease

  2023cites this paper
• The association between systemic immune-inflammation index and chronic obstructive pulmonary disease in adults aged 40 years and above in the United States: a cross-sectional study based on the NHANES 2013–2020

  2023cites this paper
• The re-emerging role of linoleic acid in paediatric asthma

  2023cites this paper
• Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage

  2023cites this paper
• Update on metabolomic findings in COPD patients

  2023cites this paper
• Mucins 3A and 3B Are Expressed in the Epithelium of Human Large Airway

  2023cites this paper
• Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

  2023cites this paper
• The value of lipid metabolites 9,10-DOA and 11,12-EET in prenatal diagnosis of fetal heart defects.

  2023cites this paper
• Differential metabolic host response to pathogens associated with community-acquired pneumonia.

  2023cites this paper
• Treatment, diagnostics, and management of chronic obstructive pulmonary disease in women

  2023cites this paper
• Metabolic landscape dysregulation in bronchoalveolar lavage fluid of checkpoint inhibitor pneumonitis.

  2023cites this paper
• Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum (Linnaeus, 1767)

  2022cites this paper
• miRNA–mRNA–protein dysregulated network in COPD in women

  2022cites this paper
• Metabolome Features of COPD: A Scoping Review

  2022cites this paper
• Sex-Specific Differences in Resolution of Airway Inflammation in Fat-1 Transgenic Mice Following Repetitive Agricultural Dust Exposure

  2022cites this paper
• Respiratory Sex Differences in Response to Smoke Exposure

  2021cites this paper
• Oogenesis and lipid metabolism in the deep-sea sponge Phakellia ventilabrum: an histological, lipidomic and transcriptomic approach

  2021cites this paper
• Untargeted metabolomics of human plasma reveal lipid markers unique to chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

  2021cites this paper
• Sex and Gender Omic biomarkers in men and women with COPD: Considerations for precision medicine.

  2021cites this paper
• Metabolomic Profiling Reveals Sex Specific Associations with Chronic Obstructive Pulmonary Disease and Emphysema

  2021cites this paper
• Metabo-Endotypes of Asthma Reveal Clinically Important Differences in Lung Function

  2021cites this paper
• Soluble Epoxide Hydrolase Deletion Attenuated Nicotine-induced Arterial Stiffness via Limiting the Loss of SIRT1.

  2021cites this paper
• Fit-for-purpose LC-MS/MS quantification of leukotoxin and leukotoxin diol in mouse plasma without sample pre-concentration.

  2021cites this paper
• Mast cells promote nitrogen mustard mediated toxicity in the lung associated with proinflammatory cytokine and bioactive lipid mediator production.

  2021cites this paper
• Metabo-Endotypes of Asthma Reveal Differences in Lung Function: Discovery and Validation in two TOPMed Cohorts.

  2021cites this paper
• Improved quantification of lipid mediators in plasma and tissues by liquid chromatography tandem mass spectrometry demonstrates mouse strain specific differences.

  2020cites this paper
• Eosinophils synthesize trihydroxyoctadecenoic acids (TriHOMEs) via a 15-lipoxygenase dependent process.

  2020cites this paper
• Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: A review of recent studies.

  2020cites this paper
• Smoking-associated increase in mucins 1 and 4 in human airways

  2020cites this paper
• COPD_A_237228 711..721

  2020cites this paper
• Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy

  2020cites this paper
• Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders

  2020cites this paper
• Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction.

  2020cites this paper
• Targeting the OXE receptor as a potential novel therapy for asthma.

  2020cites this paper
• Sex differences in lymphoid follicles in COPD airways

  2020cites this paper
• CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN WOMEN

  2019cites this paper
• New Lipid Mediators in Retinal Angiogenesis and Retinopathy

  2019cites this paper
• Dysregulation of the Tryptophan Pathway Evidences Gender Differences in COPD

  2019cites this paper
• Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1.

  2019cites this paper
• Adipose tissue oxylipin profiles vary by anatomical site and are altered by dietary linoleic acid in rats.

  2019cites this paper
• Prominent release of lipoxygenase generated mediators in a murine house dust mite-induced asthma model.

  2018cites this paper
• Different Lipid Regulation in Ovarian Cancer: Inhibition of the Immune System

  2018cites this paper
• ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages

  2018cites this paper
• Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

  2018cites this paper
• of a community-initiated position paper to develop accepted guidelines.

  2018cites this paper
• ERV1/ChemR23 Signaling protects from atherosclerosis by modifying oxLDL uptake and phagocytosis in macrophages

  2018cites this paper
• Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

  2018cites this paper
• Integration of multi-omics datasets enables molecular classification of COPD

  2018cites this paper
• Effect of psychiatric drugs on Daphnia magna oxylipin profiles.

  2018cites this paper
• From the Institute of Environmental Medicine, the Unit of Experimental Asthma and Allergy Research, and the Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II Karolinska Institutet, Stockholm, Sweden QUANTIFICATION OF INFLAMMATORY MEDIATORS TO EXPLORE MOLECULAR

  2018cites this paper
• Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study

  2018cites this paper
• MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines1

  2018cites this paper
• An LC-MS/MS workflow to characterize 16 regio- and stereoisomeric trihydroxyoctadecenoic acids[S]

  2018cites this paper
• Lipid Mediator Quantification in Isolated Human and Guinea Pig Airways: An Expanded Approach for Respiratory Research.

  2018cites this paper
• The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers

  2018cites this paper
• Regulation of inflammation by lipid mediators in oral diseases.

  2017cites this paper
• Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin–lysoPA axis in COPD

  2017cites this paper
• Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics.

  2017cites this paper
• GM‐CSF– and M‐CSF–primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures

  2017cites this paper
• Therapeutic potential of omega‐3 fatty acid‐derived epoxyeicosanoids in cardiovascular and inflammatory diseases

  2017cites this paper
• The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders

  2017cites this paper
• Proteomic and metabolomic approaches in inflammatory lung diseases

  2017cites this paper
• Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information

  2017cites this paper
• New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia

  2016influential citation