Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Cell Science

• Publication date

  2018-03-15

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1242/jcs.212506PMID 29487175PMCID PMC5897712
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2017cited by this paper
• Genetics of Congenital Cataract.

  2016cited by this paper
• Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

  2015cited by this paper
• Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules

  2015cited by this paper
• Connexin 46 (Cx46) Gap Junctions Provide a Pathway for the Delivery of Glutathione to the Lens Nucleus*

  2014cited by this paper
• Differentiating connexin hemichannels and pannexin channels in cellular ATP release

  2014cited by this paper
• Glutathione transporters.

  2013cited by this paper
• Connexin 43 Channels Protect Osteocytes Against Oxidative Stress–Induced Cell Death

  2013cited by this paper
• Antioxidants and cataract

  2013cited by this paper
• Oxidative stress defense and repair systems of the ocular lens.

  2012cited by this paper
• Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics

  2012cited by this paper
• Regulation of Human Mesenchymal Stem Cell Functions by an Autocrine Loop Involving NAD+ Release and P2Y11-Mediated Signaling

  2011cited by this paper
• Properties of connexin 46 hemichannels in dissociated lens fiber cells.

  2011cited by this paper
• Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner

  2009cited by this paper
• Oxidative Stress, Lens Gap Junctions, and Cataracts

  2009cited by this paper
• Stimulated Efflux of Amino Acids and Glutathione from Cultured Hippocampal Slices by Omission of Extracellular Calcium

  2008cited by this paper
• Promotion of lens epithelial-fiber differentiation by the C-terminus of connexin 45.6 – a role independent of gap junction communication

  2007influential reference
• A Novel Role for Connexin Hemichannel in Oxidative Stress and Smoking-Induced Cell Injury

  2007cited by this paper
• Cataract formation in a strain of rats selected for high oxidative stress.

  2004cited by this paper
• Stimulation of lens cell differentiation by gap junction protein connexin 45.6.

  2003cited by this paper
• Hemichannel and junctional properties of connexin 50.

  2002cited by this paper
• Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation.

  2002cited by this paper
• Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

  2002cited by this paper
• Molecular solutions to mammalian lens transparency.

  2001cited by this paper
• Use of retroviruses to express connexins.

  2001cited by this paper
• Glutathione: A Vital Lens Antioxidant

  2000cited by this paper
• Molecular mechanism underlying a Cx50-linked congenital cataract.

  1999cited by this paper
• Characterization of a mouse Cx50 mutation associated with the No2 mouse cataract.

  1999cited by this paper
• Connexin 50 mutation in a family with congenital "zonular nuclear" pulverulent cataract of Pakistani origin

  1999cited by this paper
• Genetic diseases and gene knockouts reveal diverse connexin functions.

  1999cited by this paper
• Molecular mechanism underlying a Cx50-linked congenital cataract.

  1999cited by this paper
• Retroviral expression of connexins in embryonic chick lens.

  1998cited by this paper
• Targeted Ablation of Connexin50 in Mice Results in Microphthalmia and Zonular Pulverulent Cataracts

  1998cited by this paper
• A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q.

  1998cited by this paper
• Disruption of α3 connexin gene leads to proteolysis and cataractogenesis in mice

  1997cited by this paper
• Connexins, connexons, and intercellular communication.

  1996cited by this paper
• Heteromeric connexons in lens gap junction channels.

  1996cited by this paper
• Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium.

  1996cited by this paper
• Molecular cloning and functional characterization of chick lens fiber connexin 45.6.

  1994cited by this paper
• Posttranslational phosphorylation of lens fiber connexin46: a slow occurrence.

  1993cited by this paper
• Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication.

  1987cited by this paper
• Chicken embryo lens cultures mimic differentiation in the lens.

  1984cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
• Cataractogenesis and molecular pathways with reactive free oxygen species as a common pathway.

  2023cites this paper
• Oxidative stress and antioxidants in cataract development

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Gap Junctions and Ageing.

  2023cites this paper
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  2022cites this paper
• Mutations of CX46/CX50 and Cataract Development

  2022cites this paper
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• Dear Editor We are submitting the manuscript “Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation” for your consideration for publication in Nitric Oxide

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