Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Genes & Nutrition

• Publication date

  2014-11-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12263-014-0442-2PMID 25416640PMCID PMC4240767
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The liver: conductor of systemic iron balance.

  2014cited by this paper
• Iron refractory iron deficiency anemia

  2013cited by this paper
• Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study

  2013cited by this paper
• Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.

  2012cited by this paper
• A genetic risk factor for low serum ferritin levels in Danish blood donors

  2012cited by this paper
• TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.

  2012cited by this paper
• Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women

  2012cited by this paper
• Candidate Gene Sequencing of SLC11A2 and TMPRSS6 in a Family with Severe Anaemia: Common SNPs, Rare Haplotypes, No Causative Mutation

  2012cited by this paper
• Associations between Single Nucleotide Polymorphisms in Iron-Related Genes and Iron Status in Multiethnic Populations

  2011cited by this paper
• Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

  2011cited by this paper
• TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals.

  2011cited by this paper
• Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.

  2011cited by this paper
• Four variants in transferrin and HFE genes as potential markers of iron deficiency anaemia risk: an association study in menstruating women

  2011cited by this paper
• Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations

  2011cited by this paper
• A genome-wide association analysis of serum iron concentrations.

  2010cited by this paper
• Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

  2009cited by this paper
• Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

  2009cited by this paper
• Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

  2009influential reference
• The Genetic Structure and History of Africans and African Americans

  2009cited by this paper
• Role of Matriptase-2 (TMPRSS6) in Iron Metabolism

  2009cited by this paper
• Iron-refractory iron deficiency anemia.

  2009cited by this paper
• A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

  2008cited by this paper
• Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

  2008cited by this paper
• Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis.

  2008cited by this paper
• The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

  2008cited by this paper
• The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

  2008cited by this paper
• Worldwide population differentiation at disease-associated SNPs

  2008cited by this paper
• Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency.

  2008cited by this paper
• Genotype, haplotype and copy-number variation in worldwide human populations

  2008cited by this paper
• Inferring Human Population Sizes, Divergence Times and Rates of Gene Flow From Mitochondrial, X and Y Chromosome Resequencing Data

  2007cited by this paper
• Common genetic variants account for differences in gene expression among ethnic groups

  2007cited by this paper
• Genotype frequency and FST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations

  2007cited by this paper
• A second generation human haplotype map of over 3.1 million SNPs

  2007cited by this paper
• 'Racial' differences in genetic effects for complex diseases

  2004cited by this paper
• Implications of biogeography of human populations for 'race' and medicine

  2004cited by this paper
• Patterns of human genetic diversity: implications for human evolutionary history and disease.

  2003cited by this paper
• Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans.

  2003cited by this paper
• Genetic analysis of African populations: human evolution and complex disease

  2002cited by this paper
• CTLA-4: new insights into its biological function and use in tumor immunotherapy

  2002cited by this paper
• Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey.

  2001cited by this paper
• A genetic developmental model of iron deficiency: biological aspects.

  1999cited by this paper
• Estimating African American admixture proportions by use of population-specific alleles.

  1998cited by this paper
• Evidence of genetic transmission in African iron overload.

  1998cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• Prevalence of iron deficiency in the United States.

  1997cited by this paper
• Primary iron overload in African Americans.

  1996cited by this paper
• Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

  1996cited by this paper
• Iron overload in African Americans.

  1995cited by this paper
• Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains.

  1995cited by this paper
• Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA.

  1993cited by this paper
• Iron nutrition does not account for the hemoglobin differences between blacks and whites.

  1992cited by this paper
• Iron overload in Africa. Interaction between a gene and dietary iron content.

  1992cited by this paper
• Comparison of hemoglobin values in black and white male U.S. military personnel.

  1983cited by this paper
• Racial differences of hemoglobin concentration: measurements of iron, copper, and zinc.

  1981cited by this paper
• Supporting Online Material Materials and Methods Figs. S1 to S3 Tables S1 to S5 References Worldwide Human Relationships Inferred from Genome-wide Patterns of Variation

  year unknowncited by this paper

• Association Between Race and Blood Ferritin Level of Whole Blood Donors

  2025cites this paper
• Association of TMPRSS6 rs1421312 polymorphism, blood groups, and iron status in pregnant Indian women with anemia

  2025cites this paper
• Evaluation of anemia and iron status in Japanese patients with gynecological malignancy: retrospective cohort study

  2025cites this paper
• Iron Intake and Human Health

  2024cites this paper
• Anaemia and iron deficiency associate with polymorphism TMPRSS6 rs855791 in Brazilian children attending day care centres

  2023cites this paper
• The role of TMPRSS6 gene polymorphism in iron resistance iron deficiency anaemia (IRIDA): a systematic review

  2023cites this paper
• Biology of Anemia: A Public Health Perspective

  2023cites this paper
• TMPRSS6 gene polymorphisms associated with iron deficiency anaemia among global population

  2022influential citation
• Iron deficiency and iron deficiency anemia in general medical practice

  2022cites this paper
• Genetic Variations of ferroportin-1(FPN1-8CG), TMPRSS6 (rs855791) and Hemojuvelin (I222N and G320V) Among a Cohort of Egyptian β-Thalassemia Major Patients

  2022cites this paper
• Associated Effect of SLC40A1 and TMPRSS6 Polymorphisms on Iron Overload

  2022cites this paper
• Common and Ethnic-Specific Genetic Determinants of Hemoglobin Concentration between Taiwanese Han Chinese and European Whites: Findings from Comparative Two-Stage Genome-Wide Association Studies.

  2022cites this paper
• Effects of probiotics on immunity and iron homeostasis: A mini-review.

  2022cites this paper
• New Insights into Iron Deficiency Anemia in Children: A Practical Review

  2022cites this paper
• Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.

  2021cites this paper
• Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

  2021cites this paper
• Common Variants in the TMPRSS6 Gene Alter Hepcidin but not Plasma Iron in Response to Oral Iron in Healthy Gambian Adults: A Recall-by-Genotype Study

  2021influential citation
• Association of SNPs within TMPRSS6 and BMP2 genes with iron deficiency status in Saudi Arabia

  2021cites this paper
• Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

  2021cites this paper
• Ethnic Differences in Iron Status.

  2021cites this paper
• Childhood anemia and iron deficiency in sub-Saharan Africa - risk factors and prevention: A review.

  2020cites this paper
• Study the association of Transmembrane Serine Protease 6 Gene Polymorphisms with Iron Deficiency Status in Saudi Arabia.

  2020cites this paper
• Iron deficiency.

  2020cites this paper
• The Association of TMPRSS6 Gene Polymorphism and Iron Intake with Iron Status among Under-Two-Year-Old Children in Lombok, Indonesia

  2019cites this paper
• A Review on Iron-Refractory Iron-Deficiency Anemia

  2019cites this paper
• Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects

  2019cites this paper
• Donor Deferral Due to Low Hemoglobin-An Updated Systematic Review.

  2019cites this paper
• Development of High-resolution Melting Assays for the Detection of Single Nucleotide Polymorphisms in Iron-related Genes: The Food and Nutrition Research Institute’s Nutritional Genomics Laboratory Experience

  2019cites this paper
• How do multilevel privacy controls affect utility‐privacy trade‐offs when used in mobile applications?

  2018cites this paper
• TMPRSS 6 Gene Polymorphism and Serum Hepcidin in Iron Deficiency Anemia 0707

  2018cites this paper
• Blood Iron Concentration and Status in Pregnant Filipino Women with Single Nucleotide Polymorphisms in HFE , TMPRSS 6 , and TF

  2018cites this paper
• New insights into iron deficiency and iron deficiency anemia.

  2017cites this paper
• Systematic evaluation of paediatric cohort with iron refractory iron deficiency anaemia (IRIDA) phenotype reveals multiple TMPRSS6 gene variations

  2017cites this paper
• Nutrigenetics in practice: little is better than nothing

  2017cites this paper
• A child with severe iron-deficiency anemia and a complex TMPRSS6 genotype

  2017cites this paper
• A structured approach to iron refractory iron deficiency anemia (IRIDA) diagnosis (SAID): The more is “SAID” about iron, the less it is

  2017cites this paper
• The iron status of a healthy South African adult population.

  2016cites this paper
• ACCEPTED MANUSCRIPT THE IRON STATUS OF A HEALTHY SOUTH AFRICAN ADULT POPULATION Running title : Iron status in South African adults

  2016cites this paper
• Multiple sclerosis-like diagnosis as a complication of previously treated malaria in an iron and vitamin D deficient Nigerian patient

  2016cites this paper
• Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study

  2016cites this paper
• Iron deficiency: new insights into diagnosis and treatment.

  2015cites this paper
• Erratum to: Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses

  2015cites this paper
• The V736A TMPRSS6 polymorphism influences liver iron concentration in nontransfusion‐dependent thalassemias

  2015cites this paper
• Transferrin receptor 2 mutations in patients with juvenile hemochromatosis phenotype

  2015cites this paper
• Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population.

  2015cites this paper