In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Angewandte Chemie

• Publication date

  2016-04-11

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/anie.201509801PMID 26970084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Determination of the Absolute Configuration of the Pseudo-Symmetric Natural Product Elatenyne by the Crystalline Sponge Method.

  2016cited by this paper
• The crystalline sponge method updated

  2016cited by this paper
• SHELXT – Integrated space-group and crystal-structure determination

  2015cited by this paper
• New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.

  2015cited by this paper
• Absolute structure determination of compounds with axial and planar chirality using the crystalline sponge method

  2015cited by this paper
• Phosphine-Catalyzed β,γ-Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center.

  2015cited by this paper
• The crystalline sponge method: MOF terminal ligand effects

  2015cited by this paper
• Analysis of rapidly synthesized guest-filled porous complexes with synchrotron radiation: practical guidelines for the crystalline sponge method

  2015cited by this paper
• Where is the Oxygen? Structural Analysis of α-Humulene Oxidation Products by the Crystalline Sponge Method.

  2015cited by this paper
• Absolute structure determination of compounds with axial and planar chirality using the crystalline sponge method

  2015cited by this paper
• Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

  2014cited by this paper
• Radical C-H functionalization of heteroarenes under electrochemical control.

  2014cited by this paper
• In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel.

  2014cited by this paper
• Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

  2014cited by this paper
• Structural reevaluation of the electrophilic hypervalent iodine reagent for trifluoromethylthiolation supported by the crystalline sponge method for X-ray analysis.

  2014cited by this paper
• The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.

  2014cited by this paper
• X-ray snapshot observation of palladium-mediated aromatic bromination in a porous complex.

  2014cited by this paper
• Preparation and guest-uptake protocol for a porous complex useful for 'crystal-free' crystallography

  2014cited by this paper
• Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

  2013cited by this paper
• X-ray analysis on the nanogram to microgram scale using porous complexes

  2013cited by this paper
• Corrigendum: X-ray analysis on the nanogram to microgram scale using porous complexes

  2013cited by this paper
• Keap calm, and carry on covalently.

  2013cited by this paper
• Et3B-mediated radical-polar crossover reaction for single-step coupling of O,Te-acetal, α,β-unsaturated ketones, and aldehydes/ketones.

  2013cited by this paper
• Studies of Reversible Conjugate Additions

  2013cited by this paper
• Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.

  2012cited by this paper
• Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

  2012cited by this paper
• Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.

  2011cited by this paper
• Crystalline molecular flasks.

  2011cited by this paper
• An Exceptionally Potent Inducer of Cytoprotective Enzymes

  2010cited by this paper
• X-ray observation of a transient hemiaminal trapped in a porous network

  2009cited by this paper
• The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

  2008cited by this paper
• Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.

  2005cited by this paper
• Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

  2005cited by this paper
• Crystal-to-crystal guest exchange of large organic molecules within a 3D coordination network.

  2004cited by this paper
• A springlike 3D-coordination network that shrinks or swells in a crystal-to-crystal manner upon guest removal or readsorption.

  2002cited by this paper
• Inflammation and cancer

  2002cited by this paper
• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  2002cited by this paper
• Reactive oxygen-mediated protein oxidation in aging and disease.

  1997cited by this paper
• Equilibrium reactions of n-butanethiol with some conjugated heteroenoid compounds

  1968cited by this paper

• Advances in crystallization chaperones based on a host-guest system for structural determination of difficult-to-crystallize molecules

  2025cites this paper
• Ammonium Organosulfonates as Machine Learning-Driven “Crystallization Cocktails” for the Structure Determination of Liquid Molecules

  2025cites this paper
• Cysteine Alkylation in Enzymes and Transcription Factors: A Therapeutic Strategy for Cancer

  2025cites this paper
• A near-infrared light-triggered covalent nanodrug for combined singlet oxygen therapy and photothermal therapy.

  2025cites this paper
• Trace benzoquinone inducing periodate for tetracyclines selective degradation: Role of the unstable intermediate

  2024cites this paper
• Post‐Synthetic Surface Modification of Metal–Organic Frameworks and Their Potential Applications

  2023cites this paper
• Capturing the Precise Structure of Liquids: The Crystalline Sponge Method for an Undergraduate Laboratory Course

  2023cites this paper
• Host–guest system of a phosphorylated macrocycle assisting structure determination of oily molecules in single-crystal form

  2023cites this paper
• ベイズ推定による単結晶試料の事前評価

  2023cites this paper
• Diastereoselective guest-shape dependent [2+2]-photodimerization of 2-cyclopenten-1-one trapped within a metal-organic framework.

  2023cites this paper
• Eliminating Transition State Calculations for Faster and More Accurate Reactivity Prediction in Sulfa-Michael Additions Relevant to Human Health and the Environment

  2022cites this paper
• Highly Luminescent Crystalline Sponge: Sensing Properties and Direct X-ray Visualization of the Substrates

  2022cites this paper
• The benefits of Cu Kβ radiation for the single-crystal X-ray structure determination of crystalline sponges

  2022cites this paper
• Applications of the crystalline sponge method and developments of alternative crystalline sponges

  2022cites this paper
• Design, synthesis, and biological evaluation of quinazoline derivatives with covalent reversible warheads as potential FGFR4 inhibitors.

  2022cites this paper
• A novel crystalline template for the structural determination of flexible chain compounds of nanoscale length

  2022cites this paper
• Metal-organic materials with triazine-based ligands: From structures to properties and applications

  2021cites this paper
• Application of Crystalline Matrices for the Structural Determination of Organic Molecules

  2021cites this paper
• Elucidating pore chemistry within metal–organic frameworks via single crystal X-ray diffraction; from fundamental understanding to application

  2021cites this paper
• Applying the Crystalline Sponge Method to Agrochemicals: Obtaining X-ray Structures of the Fungicide Metalaxyl-M and Herbicide S-Metolachlor

  2021cites this paper
• Supramolecular aspects of biomolecule interactions in metal–organic frameworks

  2021cites this paper
• Crystalline Sponge Affinity Screening: A Fast Tool for Soaking Condition Optimization without the Need of X-ray Diffraction Analysis.

  2021cites this paper
• Hydrogen bonded frameworks: smart materials used smartly

  2021cites this paper
• Hydrophobicity Directed Guest-Inclusion for Structure-Elucidation of Enclatherated Guests within a Crystalline Sponge by SC-XRD

  2021cites this paper
• Macrocycle‐Based Crystalline Sponge that Stabilizes and Lights Up Cationic Aggregation‐Caused Quenching Dyes

  2021cites this paper
• One-Step Synthesis of Cyclophanes as Crystalline Sponge and Their [2]Catenanes through SNAr Reactions.

  2020cites this paper
• Divergent Michael/Aldol Cascades Under Semi-Aqueous Conditions: Synthesis of Cyclopenta- and Cycloheptannulated (Hetero)arenes.

  2020cites this paper
• Encapsulation of Aromatic Compounds and a Non-Aromatic Herbicide into a Gadolinium-Based Metal–Organic Framework via the Crystalline Sponge Method

  2020cites this paper
• Solid-state host–guest influences on a BODIPY dye hosted within a crystalline sponge

  2020cites this paper
• Multivariate Metal-Organic Frameworks for the Simultaneous Capture of Organic and Inorganic Contaminants from Water.

  2019cites this paper
• Chemoselective Synthesis of N-Terminal Cysteinyl Thioesters via β,γ-C,S Thiol-Michael Addition.

  2019cites this paper
• Hydrogen-bonded frameworks for molecular structure determination

  2019cites this paper
• DFT-calculated structures based on 1H NMR chemical shifts in solution vs. structures solved by single-crystal X-ray and crystalline-sponge methods: Assessing specific sources of discrepancies

  2018cites this paper
• Crystalline-Sponge-Based Structural Analysis of Crude Natural Product Extracts.

  2018cites this paper
• Evaluating Iodine Uptake in a Crystalline Sponge Using Dynamic X-ray Crystallography.

  2018cites this paper
• Protecting-Group-Free Site-Selective Reactions in a Metal-Organic Framework Reaction Vessel.

  2018cites this paper
• C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

  2018cites this paper
• Highly Reactive and Tracelessly Cleavable Cysteine-Specific Modification of Proteins via 4-Substituted Cyclopentenone.

  2018cites this paper
• Lanthanide Discrimination with Hydroxyl-Decorated Flexible Metal-Organic Frameworks.

  2018cites this paper
• Review: Metal-organic framework based crystalline sponge method for structure analysis

  2018cites this paper
• Crystallographic snapshots of host‒guest interactions in drugs@metal‒organic frameworks: towards mimicking molecular recognition processes

  2018cites this paper
• Proton in a Confined Space: Structural Studies of H+ ⊂Crypt-111 Iodide and Some Halogen-Bonded Derivatives.

  2017cites this paper
• Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation.

  2017cites this paper
• Structural Elucidation of Trace Amounts of Volatile Compounds Using the Crystalline Sponge Method.

  2017cites this paper
• Racemic and Enantiopure Camphene and Pinene Studied by the Crystalline Sponge Method

  2017cites this paper
• Crystallography of encapsulated molecules.

  2017cites this paper
• A flexible thioether-based MOF as a crystalline sponge for structural characterization of liquid organic molecules

  2017cites this paper
• Flexible Zirconium MOF as the Crystalline Sponge for Coordinative Alignment of Dicarboxylates.

  2017cites this paper
• Enzymology and inhibition of ghrelin acylation by ghrelin O-acyltransferase

  2017cites this paper
• Fine-tuning of the confined space in microporous metal–organic frameworks for efficient mercury removal

  2017cites this paper
• X-ray Structure Analysis of N-Containing Nucleophilic Compounds by the Crystalline Sponge Method.

  2017cites this paper
• Characterization of Covalent-Reversible EGFR Inhibitors

  2017cites this paper
• Hidden Transformations of a Crystalline Sponge: Elucidating the Stability of a Highly Porous Three-Dimensional Metal–Organic Framework

  2016cites this paper
• Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme.

  2016cites this paper
• High-resolution X-ray structure of methyl salicylate, a time-honored oily medicinal drug, solved by crystalline sponge method

  2016cites this paper
• X-ray Structure Analysis of Ozonides by the Crystalline Sponge Method.

  2016cites this paper
• Improvements to the Practical Usability of the "Crystalline Sponge" Method for Organic Structure Determination.

  2016cites this paper
• Differentiation of volatile aromatic isomers and structural elucidation of volatile compounds in essential oils by combination of HPLC separation and crystalline sponge method.

  2016cites this paper
• Undeniable Confirmation of the syn-Addition Mechanism for Metal-Free Diboration by Using the Crystalline Sponge Method.

  2016cites this paper