Functional blockade of opioid analgesia by orphanin FQ/nociceptin.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Biochemical Pharmacology

• Publication date

  1998-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-2952(98)00023-9PMID 10076548
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain.

  1997cited by this paper
• Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception.

  1997cited by this paper
• 3‐Methoxynaltrexone, a selective heroin/morphine‐6β‐glucuronide antagonist

  1997cited by this paper
• Pharmacological Characterization of Orphanin FQ / Nociceptin and its Fragments 1

  1997cited by this paper
• Pharmacological characterization of orphanin FQ/nociceptin and its fragments.

  1997cited by this paper
• Spinal analgesic activity of orphanin FQ/nociceptin and its fragments.

  1997cited by this paper
• Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat.

  1997cited by this paper
• Novel receptor mechanisms for heroin and morphine-6β-glucuronide analgesia☆

  1996cited by this paper
• Orphanin FQ acts as a supraspinal, but not a spinal, anti‐opioid peptide

  1996cited by this paper
• Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat.

  1996cited by this paper
• Orphanin FQ is a functional anti-opioid peptide.

  1996cited by this paper
• Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.

  1996cited by this paper
• Structure and characterization of the gene encoding a mouse kappa3-related opioid receptor.

  1996cited by this paper
• Novel receptor mechanisms for heroin and morphine-6 beta-glucuronide analgesia.

  1996cited by this paper
• Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits.

  1996cited by this paper
• Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ

  1996cited by this paper
• Differential blockade of morphine and morphine-6β-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein α subunits in rats

  1995cited by this paper
• Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

  1995cited by this paper
• Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor.

  1995cited by this paper
• Antisense Oligodeoxynucleotides to the Cloned δ Receptor DOR‐1: Uptake, Stability, and Regulation of Gene Expression

  1995cited by this paper
• Antisense mapping the MOR‐1 opioid receptor: evidence for alternative splicing and a novel morphine‐6β‐glucuronide receptor

  1995cited by this paper
• Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology.

  1995cited by this paper
• Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

  1995cited by this paper
• Correlating the Pharmacology and Molecular Biology of Opioid Receptors

  1995cited by this paper
• Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

  1995cited by this paper
• Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats.

  1995cited by this paper
• An opiate-receptor gene family reunion.

  1994cited by this paper
• Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

  1994cited by this paper
• Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type.

  1994cited by this paper
• Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors

  1994cited by this paper
• Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.

  1994cited by this paper
• cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

  1994cited by this paper
• ORL1, a novel member of the opioid receptor family

  1994cited by this paper
• Selective loss of δ opioid analgesia and binding by antisense oligodeoxynucleotides to a δ opioid receptor

  1994cited by this paper
• Cloning, expression and classification of a kappa3-related opioid receptor using antisense oligodeoxynucleotides☆

  1994cited by this paper
• cDNA cloning and regional distribution of a novel member of the opioid receptor family

  1994cited by this paper
• Isolation of cDNA clones homologous to opioid receptors

  1994cited by this paper
• Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

  1994cited by this paper
• Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor.

  1994cited by this paper
• Irreversible opiate agonists and antagonists: V. Hydrazone and acylhydrazone derivatives of naltrexone.

  1988cited by this paper
• Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.

  1957cited by this paper

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• Etude du peptidome du cervelet de rat au cours du développement et identification des effets neurotrophiques de la nociceptine dans la mise en place des neurones en grain.

  2017cites this paper
• Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

  2017cites this paper
• Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain

  2016cites this paper
• Central N/OFQ-NOP Receptor System in Pain Modulation.

  2016cites this paper
• Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

  2016cites this paper
• Functional plasticity of the N/OFQ‐NOP receptor system determines analgesic properties of NOP receptor agonists

  2014cites this paper
• ( for IUPHAR ) Revolution in GPCR Signaling : Opioid receptor heteromers as novel therapeutic targets 1 Abbreviated title : Opioid receptor heteromers as therapeutic targets

  2014cites this paper
• Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10

  2014cites this paper
• Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.

  2013cites this paper
• Nociceptin/orphanin FQ - NOP receptor system: novel genetic and pharmacological tools

  2011cites this paper
• Opioidergic Transmission in the Dorsal Horn

  2009cites this paper
• Nociceptin/orphanin FQ receptor ligands : pharmacological studies

  2009cites this paper
• Coinvolgimento del recettore NOP nei meccanismi molecolari attivati da esposizione cronica a cannabinoidi, oppiacei ed alcol

  2008cites this paper
• Role of nociceptin/orphanin FQ and the pseudopeptide [Phe1Psi(CH2NH)Gly2]-nociceptin(1-13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersa.

  2008cites this paper
• Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.

  2007cites this paper
• Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system.

  2007cites this paper
• chapter 113 – Opioid Analgesics

  2007cites this paper
• Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a micro-opioid receptor agonist and an ORL1 receptor antagonist.

  2007cites this paper
• Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-amide.

  2006cites this paper
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  2003cites this paper
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  2003cites this paper
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• Nociceptin und der ORL1-Rezeptor

  2002cites this paper
• [Nociceptin and the ORL1 receptor: pharmacology of a new opioid receptor].

  2002cites this paper
• Nociceptin und der ORL1-Rezeptor Pharmakologie eines neuen Opioidrezeptors

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  2002cites this paper
• Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype.

  2002cites this paper
• Effects of naloxone benzoylhydrazone on native and recombinant nociceptin/orphanin FQ receptors.

  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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• Potentiation of Opioid Analgesia in Dopamine2Receptor Knock-Out Mice: Evidence for a Tonically Active Anti-Opioid System

  2001influential citation
• Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice.

  2001cites this paper
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  2001cites this paper
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  2000cites this paper
• Pharmacological characterization of the nociceptin receptor, ORL1. Insight from the inward rectifier activation in the periaqueductal gray.

  2000cites this paper
• Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin.

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• Pharmacological Characterization of the Nociceptin Receptor, ORL1

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• Effects of supraspinal orphanin FQ/nociceptin.

  2000cites this paper
• [125I]orphanin FQ/nociceptin binding in Raji cells

  1999cites this paper
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  1999cites this paper
• Orphanin FQ suppresses NMDA receptor-dependent long-term depression and depotentiation in hippocampal dentate gyrus.

  1999cites this paper
• Identification and differential regional expression of KOR‐3/ORL‐1 gene splice variants in mouse brain

  1998cites this paper
• Toward a functional characterization of orphanin FQ/nociceptin: Parametric and organismic considerations

  1998cites this paper