Natural merodiploidy involving duplicated rpoB alleles affects secondary metabolism in a producer actinomycete

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Molecular Microbiology

• Publication date

  2004-11-25

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/j.1365-2958.2004.04406.xPMID 15659159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of antibiotic production in streptomyces coelicolor

  2006cited by this paper
• Primary structure of Escherichia coli RNA polymerase nucleotide substitution in the β subunit gene of the rifampicin resistant rpoB255 mutant

  2004cited by this paper
• RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominance

  2004cited by this paper
• Signalling early developmental events in two highly diverged Streptomyces species

  2003cited by this paper
• The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.

  2003cited by this paper
• Essential Steps in the ppGpp-dependent Regulation of Bacterial Ribosomal RNA Promoters Can Be Explained by Substrate Competition*

  2003cited by this paper
• Activation of Antibiotic Biosynthesis by Specified Mutations in the rpoB Gene (Encoding the RNA Polymerase β Subunit) of Streptomyces lividans

  2002influential reference
• A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2)

  2002cited by this paper
• Regulation of ribosomal RNA synthesis in E. coli: effects of the global regulator guanosine tetraphosphate (ppGpp).

  2002cited by this paper
• Regulation of Bacterial Antibiotic Production

  2001cited by this paper
• Glycopeptide derivatives.

  2001cited by this paper
• Mutational Analysis and Reconstituted Expression of the Biosynthetic Genes Involved in the Formation of 3-Amino-5-hydroxybenzoic Acid, the Starter Unit of Rifamycin Biosynthesis in Amycolatopsis mediterraneiS699*

  2001cited by this paper
• Practical streptomyces genetics

  2000cited by this paper
• A Structural Model of Transcription Elongation

  2000cited by this paper
• A structural model of transcription elongation.

  2000cited by this paper
• Actinomycete Development, Antibiotic Production, and Phylogeny: Questions and Challenges

  2000cited by this paper
• Influence of carbon and nitrogen sources on Flavobacteriumgrowth and zeaxanthin biosynthesis

  1999cited by this paper
• The rpoB mutants destabilizing initiation complexes at stringently controlled promoters behave like "stringent" RNA polymerases in Escherichia coli.

  1998cited by this paper
• The relA/spoT-Homologous Gene inStreptomyces coelicolor Encodes Both Ribosome-Dependent (p)ppGppSynthesizing and -Degrading Activities

  1998cited by this paper
• Reclassification of Thermomonospora and Microtetraspora.

  1998cited by this paper
• The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation

  1997cited by this paper
• Modular organization of the catalytic center of RNA polymerase.

  1997cited by this paper
• The regulation of antibiotic production in Streptomyces coelicolor A3(2)

  1996cited by this paper
• Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2)

  1996cited by this paper
• Isolation, purification, and in vitro characterization of recessive-lethal-mutant RNA polymerases from Escherichia coli

  1996cited by this paper
• 1995 Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2).

  1996cited by this paper
• The stringent response

  1996cited by this paper
• The Stringent Response, ppGpp and Antibiotic Production in Streptomyces coelicolor A3(2)

  1994influential reference
• Bacillus Subtilis and Other Gram-Positive Bacteria: Biochemistry, Physiology, and Molecular Genetics

  1993cited by this paper
• Genetic dissection of the transcription cycle. A mutant RNA polymerase that cannot hold onto a promoter.

  1992cited by this paper
• Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strain.

  1992cited by this paper
• RpoB8, a rifampicin-resistant termination-proficient RNA polymerase, has an increased Km for purine nucleotides during transcription elongation.

  1991cited by this paper
• Amino acid changes in conserved regions of the beta-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination.

  1990cited by this paper
• Streptomyces relC mutants with an altered ribosomal protein ST-L11 and genetic analysis of a Streptomyces griseus relC mutant

  1990cited by this paper
• Characterization of the termination phenotypes of rifampicin-resistant mutants.

  1988cited by this paper
• Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.

  1988cited by this paper
• Effects of rifampicin resistant rpoB mutations on antitermination and interaction with nusA in Escherichia coli.

  1988cited by this paper
• A40926, a new glycopeptide antibiotic with anti-Neisseria activity

  1987cited by this paper
• Microbial ecology and evolution: a ribosomal RNA approach.

  1986cited by this paper
• [Localization of mutation leading to resistance of E. coli RNA polymerase to the antibiotic streptolydigin in the gene rpoB coding for the beta-subunit of the enzyme].

  1985cited by this paper
• [Primary structure of Escherichia coli RNA-polymerase. Nucleotide sequence of gene rpoB and amino acid sequence of the beta-subunit].

  1980cited by this paper
• 3-Amino-5-hydroxybenzoic acid as a key intermediate in ansamycin and maytansinoid biosynthesis

  1980cited by this paper
• Nitrogen nutrition and regulation of cephalosporin production in Streptomyces clavuligerus.

  1979cited by this paper
• Thiostrepton-resistant mutants exhibit relaxed synthesis of RNA.

  1978cited by this paper
• RNA synthesis in Streptomyces antibioticus: in vitro effects of actinomycin and transcriptional inhibitors from 48-h cells.

  1976cited by this paper
• On Stringent Response

  1972cited by this paper

• Modulators of a robust and efficient metabolism: Perspective and insights from the Rid superfamily of proteins.

  2023cites this paper
• Advanced wastewater treatment and membrane fouling control by electro-encapsulated self-forming dynamic membrane bioreactor

  2022cites this paper
• Interplay between non-coding RNA transcription, stringent phenotype and antibiotic production in Streptomyces.

  2022cites this paper
• Development of a database and standardized approach for rpoB sequence-based subtyping and identification of aerobic spore-forming Bacillales.

  2021cites this paper
• Interplay between Non-Coding RNA Transcription, Stringent/Relaxed Phenotype and Antibiotic Production in Streptomyces ambofaciens

  2021cites this paper
• Innovative encapsulated self-forming dynamic bio-membrane bioreactor (ESFDMBR) for efficient wastewater treatment and fouling control.

  2021cites this paper
• Serendipity Reveals the Function and Physiological Role of a Large Family of Proteins

  2021cites this paper
• Rid7C, a Member of the YjgF/YER057c/UK114 (Rid) Protein Family, Is a Novel Endoribonuclease That Regulates the Expression of a Specialist RNA Polymerase Involved in Differentiation in Nonomuraea gerenzanensis

  2021influential citation
• Preferential Use of the Perchlorate over the Nitrate in the Respiratory Processes Mediated by the Bacterium Azospira sp. OGA 24

  2020cites this paper
• New Molecular Tools for Regulation and Improvement of A40926 Glycopeptide Antibiotic Production in Nonomuraea gerenzanensis ATCC 39727

  2020cites this paper
• New compounds for a good old class: Synthesis of two Β-lactam bearing cephalosporins and their evaluation with a multidisciplinary approach.

  2020cites this paper
• Evolutionary dynamics of natural product biosynthesis in bacteria.

  2019cites this paper
• The Application of Ribosome Engineering to Natural Product Discovery and Yield Improvement in Streptomyces

  2019cites this paper
• Rifampin resistance and its fitness cost in Riemerella anatipestifer

  2019cites this paper
• Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering

  2019cites this paper
• Complex Regulatory Networks Governing Production of the Glycopeptide A40926

  2018cites this paper
• Old and new glycopeptide antibiotics: From product to gene and back in the post-genomic era.

  2018influential citation
• Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects

  2016cites this paper
• Engineering microbial hosts for production of bacterial natural products.

  2016cites this paper
• Production of Antibacterial Compounds from Actinomycetes

  2016cites this paper
• The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated “magic” RNA polymerase

  2016cites this paper
• The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated “magic” RNA polymerase

  2016cites this paper
• The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites

  2015cites this paper
• The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

  2015cites this paper
• Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering.

  2015cites this paper
• The respiratory chains of four strains of the alkaliphilic Bacillus clausii

  2014cites this paper
• The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?

  2014cites this paper
• Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107

  2014cites this paper
• Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

  2014cites this paper
• Comparative genomics revealed key molecular targets to rapidly convert a reference rifamycin-producing bacterial strain into an overproducer by genetic engineering.

  2014cites this paper
• Triggers and cues that activate antibiotic production by actinomycetes

  2014cites this paper
• Fitness Costs of Antibiotic Resistance

  2013cites this paper
• Tracing the Variation in Physiological Response to Rifampicin Across the Microbial Spectrum

  2012cites this paper
• The fitness costs of drug resistance mutations in Mycobacteria

  2012cites this paper
• Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain

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  2012cites this paper
• Modulating antimicrobial activity by synthesis: dendritic copolymers based on nonquaternized 2-(dimethylamino)ethyl methacrylate by Cu-mediated ATRP.

  2012cites this paper
• Strain improvement in actinomycetes in the postgenomic era

  2011cites this paper
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  2010cites this paper
• Assessment of perchlorate-reducing bacteria in a highly polluted river.

  2010cites this paper
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  2010influential citation
• Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns.

  2010cites this paper
• Application of XeCl308 nm excimer laser radiation to mutagenesis of industrial microorganisms

  2008cites this paper
• Activation of Dormant Bacterial Genes by Nonomuraea sp. Strain ATCC 39727 Mutant-Type RNA Polymerase

  2008cites this paper
• Natural Merodiploidy of the lux-rib Operon of Photobacterium leiognathi from Coastal Waters of Honshu, Japan

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• The impact of environmental perturbation on microbial community structure and dynamics: Factors affecting growth of Clonothrix fusca in groundwater

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• Clonothrix fusca Roze 1896, a filamentous, sheathed, methanotrophic gamma-proteobacterium.

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• Clonothrix fusca Roze 1896, a Filamentous, Sheathed, Methanotrophic (cid:2) -Proteobacterium (cid:1) †

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• Isolation of a psychrotolerant Debaryomyces hansenii strain from fermented tea plant (Camellia sinensis) leaves

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  2007cites this paper
• Structure and expression of the atp operon coding for F1F0-ATP synthase from the antibiotic-producing actinomycete Nonomuraea sp. ATCC 39727.

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• Contribution of rpoB2 RNA Polymerase (cid:2) Subunit Gene to Rifampin Resistance in Nocardia Species

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• Contribution of rpoB2 RNA Polymerase β Subunit Gene to Rifampin Resistance in Nocardia Species

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