Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans.

AIM To investigate genetic polymorphism and haplotypes of tightly linked X-chromosomal short tandem repeat (X-STR) clusters in Koreans. METHODS Four X-STR duos in the linkage group 1-4 (DXS10135-DXS8378, DXS7132-DXS10074, HPRTB-DXS10101, and DXS10134-DXS7423) were investigated in 450 unrelated Koreans (300 men and 150 women) using the Mentype Argus X-8 Polymerase Chain Reaction Amplification Kit. RESULTS No significant deviation from Hardy-Weinberg equilibrium was observed in any of the 8 loci. DXS10135 was the most polymorphic X-STRs, with 25 alleles and DXS7423 was the least informative, with 5 alleles. Eleven off-ladder alleles and a triallelic pattern were observed, and these alleles were characterized by cloning and sequencing analysis. In 300 Korean men, 38 to 59 haplotypes were observed for each linkage duo with 91.6-96.6% of haplotype diversities. However, due to the low genetic diversity of DXS7423, the X-STR duo in linkage group 4 (DXS10134-DXS7423), in comparison with other linkage duos, had considerably lower haplotype diversity values (91.6%) with 3 common haplotypes (35-15, 36-15, and 37-15) observed in 44.3% of Koreans. CONCLUSION Four X-STR duos in the linkage group 1-4 will be able to provide a powerful tool for solving complex kinship cases in Koreans. However, to increase the haplotype diversity in the linkage group 4, it will be useful to discover a new marker for Asians that can serve as an adequate substitute for DXS7423 or at least complement the existing linkage duo of DXS10134-DXS7423.

• Publication year

  2009

• Venue

  Croatian Medical Journal

• Publication date

  2009-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3325/CMJ.2009.50.305PMID 19480025PMCID PMC2702743
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterisation of the STR markers DXS10146, DXS10134 and DXS10147 located within a 79.1 kb region at Xq28.

  2008cited by this paper
• Population genetic evaluation of eight X-chromosomal short tandem repeat loci using Mentype Argus X-8 PCR amplification kit.

  2008cited by this paper
• Hungarian population data of eight X-linked markers in four linkage groups.

  2008cited by this paper
• Population data of eight X-chromosomal STR markers in Ewe individuals from Ghana

  2008cited by this paper
• Use of eight X-chromosomal STRs in paternity investigation

  2008cited by this paper
• Polymorphism of eight X-chromosomal STRs in a Japanese population

  2008cited by this paper
• Population data of 8 X-STRs in South Italy (Calabria) using the Mentype® Argus X-8 PCR Amplification Kit (Biotype)

  2008cited by this paper
• X-chromosomal markers: past, present and future.

  2007cited by this paper
• DXS10079, DXS10074 and DXS10075 are STRs located within a 280-kb region of Xq12 and provide stable haplotypes useful for complex kinship cases

  2006cited by this paper
• A genetic basis for anomalous band patterns encountered during DNA STR profiling.

  2004cited by this paper
• Five highly informative X-chromosomal STRs in Koreans

  2004cited by this paper
• DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

  2004cited by this paper
• Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898

  2004cited by this paper
• Use of X-linked markers for forensic purposes

  2003cited by this paper
• Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat.

  1998cited by this paper
• DNA recommendations. Further report of the DNA Commission of the ISFH regarding the use of short tandem repeat systems. International Society for Forensic Haemogenetics.

  1997cited by this paper
• DNA recommendations

  1997cited by this paper
• DNA RECOMMENDATIONS : FURTHER REPORT OF THE DNA COMMISSION OF THE ISFH REGARDING THE USE OF SHORT TANDEM REPEAT SYSTEMS

  1997cited by this paper

• Allelic and haplotype diversity of 12 X-chromosomal short tandem repeats in Koreans, with an analysis of anomalous profiles.

  2024cites this paper
• Investigation of X-STR haplotype diversity in the Australian Aboriginal population

  2022cites this paper
• Compilation and investigation of Australian Aboriginal X-STR haplotypes using the Investigator® Argus X-12 QS Kit

  2020cites this paper
• Genetic analysis of 12 X-short tandem repeats loci in a northern Thai population

  2020cites this paper
• X-STRs: Potentials and Applications

  2020cites this paper
• Allelic and haplotype diversity of 12 X-STRs in the United Arab Emirates.

  2017cites this paper
• Chinese Xibe population genetic composition according to linkage groups of X-chromosomal STRs: population genetic variability and interpopulation comparisons

  2017influential citation
• Population genetic data for 12 X-STR loci in the Northern Han Chinese and StatsX package as tools for population statistics on X-STR.

  2017cites this paper
• Forensic Science International: Genetics

  2015cites this paper
• Forensic typing of short tandem repeat markers on the X and Y chromosomes.

  2015cites this paper
• STR Profiles: Multiplex PCR, Tri-Alleles, Amelogenin, and Partial Profiles

  2015cites this paper
• Lineage Marker Statistics

  2015cites this paper
• Genetic polymorphisms of 12 X‐chromosomal STR loci in Taiwanese individuals and likelihood ratio calculations applied to case studies of blood relationships

  2014cites this paper
• Basic Genetics and Human Genetic Variation

  2014cites this paper
• Population genetic investigation of eight X-chromosomal short tandem repeat loci from a northeast German sample.

  2012cites this paper
• Genetic diversity of 12 X-chromosomal short tandem repeats in the Moroccan population.

  2012cites this paper
• Genetic characterization of Western Iberia using Mentype® Argus X-8 kit.

  2012cites this paper
• Distribution of 8 X-chromosomal STR loci in an Italian population sample (Calabria).

  2012cites this paper
• X-Chromosome Analysis

  2012cites this paper
• Analysis of 12 X-STRs in Greenlanders, Danes and Somalis using Argus X-12

  2011influential citation
• Genetic polymorphisms of twelve X-chromosomal STR loci in Chinese Han population from Guangdong Province.

  2011cites this paper
• Variations in short tandem repeats deduced on the basis of the number of repeats and the relationship of these variations with longevity

  2011cites this paper
• Population genetic study of six closely linked groups of X-STRs in a Japanese population

  2011cites this paper
• INDIVÍDUOS DA REGIÃO SUL DO BRASIL

  2010cites this paper
• Characteristics of eight X-STR loci for forensic purposes in the Chinese population

  2009cites this paper
• Population genetic study of four closely-linked X-STR trios in Koreans

  2009cites this paper