SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Oncogene

• Publication date

  2014-04-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2013.140PMID 23624922
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

  2012cited by this paper
• Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma.

  2012cited by this paper
• Genome-wide profiling of DNA-binding proteins using barcode-based multiplex Solexa sequencing.

  2012cited by this paper
• Standardized Relative Quantification of Immunofluorescence Tissue Staining

  2012cited by this paper
• Global cancer statistics

  2011cited by this paper
• Sprouty-2 Controls c-Met Expression and Metastatic Potential of Colon Cancer Cells: Sprouty/c-Met Upregulation in Human Colonic Adenocarcinomas

  2010cited by this paper
• SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity

  2010cited by this paper
• Epidermal stem cell diversity and quiescence

  2009cited by this paper
• Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

  2009cited by this paper
• Sprouty proteins: modified modulators, matchmakers or missing links?

  2009cited by this paper
• ERBBs in the gastrointestinal tract: recent progress and new perspectives.

  2009cited by this paper
• Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.

  2009cited by this paper
• Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology.

  2008cited by this paper
• Sprouty proteins, masterminds of receptor tyrosine kinase signaling

  2008cited by this paper
• The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

  2008cited by this paper
• Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas

  2008cited by this paper
• Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity*

  2008cited by this paper
• The FoxO code

  2008cited by this paper
• Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.

  2007cited by this paper
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

  2007cited by this paper
• Wnt/β-Catenin Is Essential for Intestinal Homeostasis and Maintenance of Intestinal Stem Cells

  2007cited by this paper
• Direct Binding of PP2A to Sprouty2 and Phosphorylation Changes Are a Prerequisite for ERK Inhibition Downstream of Fibroblast Growth Factor Receptor Stimulation*

  2007cited by this paper
• Tracking down the stem cells of the intestine: strategies to identify adult stem cells.

  2007cited by this paper
• Spatial regulation of EGFR signaling by Sprouty2.

  2007cited by this paper
• The Intestinal Wnt/TCF Signature.

  2007cited by this paper
• Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma.

  2006cited by this paper
• Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

  2006cited by this paper
• Regulation of Sprouty Stability by Mnk1-Dependent Phosphorylation

  2006cited by this paper
• Sprouty and cancer: the first terms report.

  2006cited by this paper
• Functional Interaction Between ß-Catenin and FOXO in Oxidative Stress Signaling

  2005cited by this paper
• Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling.

  2005cited by this paper
• Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines.

  2005cited by this paper
• Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

  2005cited by this paper
• Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

  2005cited by this paper
• Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells.

  2005cited by this paper
• Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.

  2004cited by this paper
• SPRY2 Is an Inhibitor of the Ras/Extracellular Signal-Regulated Kinase Pathway in Melanocytes and Melanoma Cells with Wild-Type BRAF but Not with the V599E Mutant

  2004cited by this paper
• Tyrosine Phosphorylation of Sprouty2 Enhances Its Interaction with c-Cbl and Is Crucial for Its Function*

  2003cited by this paper
• Split personalities: the agonistic antagonist Sprouty

  2003cited by this paper
• Functional analysis of the human Sprouty2 gene promoter.

  2003cited by this paper
• The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

  2002cited by this paper
• Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

  2002cited by this paper
• Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

  2002cited by this paper
• Wnt-3A/β-Catenin Signaling Induces Transcription from the LEF-1 Promoter* 210

  2002cited by this paper
• The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

  2002cited by this paper
• The -Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

  2002cited by this paper
• Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling

  2001cited by this paper
• Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells

  2001cited by this paper
• Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1

  2000cited by this paper
• Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.

  2000cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Lessons from Hereditary Review Colorectal Cancer

  1996cited by this paper

• The future of Forkhead box O transcription factors

  2026cites this paper
• FOXO3a-interacting proteins’ involvement in cancer: a review

  2024cites this paper
• Aberrant Expression of Sprouty2 In Human Colon Cancer

  2024cites this paper
• Dual role of sprouty2 as an inhibitor of RAS/ERK‐driven proliferation and a promoter of cancer invasion in KRAS wild‐type colorectal cancer

  2023cites this paper
• MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis

  2022cites this paper
• API-2-Induced Cell Migration Is Overcome by Small Molecular Approaches Inhibiting β-Catenin

  2022cites this paper
• 6-Shogaol Suppresses the Progression of Liver Cancer via the Inactivation of Wnt/[Formula: see text]-Catenin Signaling by Regulating TLR4.

  2021cites this paper
• Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

  2021cites this paper
• Vitamin D Effects on Cell Differentiation and Stemness in Cancer

  2020cites this paper
• Mechanisms of action of vitamin D in colon cancer.

  2019cites this paper
• Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

  2019cites this paper
• FOXO transcription factors at the interface of metabolism and cancer

  2017cites this paper
• Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein

  2017cites this paper
• Lipid fingerprint image accurately conveys human colon cell pathophysiologic state: A solid candidate as biomarker.

  2016cites this paper
• SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150

  2016cites this paper
• Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression

  2016cites this paper
• Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial–mesenchymal transition

  2015cites this paper
• Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer

  2015cites this paper
• Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma

  2015cites this paper
• Oncogenes and Tumor Suppressors Sprouty 2 Drives Drug Resistance and Proliferation in Glioblastoma

  2015cites this paper
• Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

  2015cites this paper
• Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer

  2015cites this paper
• Portrait of the PI3K/AKT pathway in colorectal cancer.

  2015cites this paper
• Direct Fluorescent Detection of a Polymethoxyflavone in Cell Culture and Mouse Tissue.

  2015cites this paper
• FOXO3a: A Potential Target in Prostate Cancer.

  2014cites this paper
• β-Catenin Enhances Odontoblastic Differentiation of Dental Pulp Cells through Activation of Runx2

  2014cites this paper
• Forkhead Box Transcription Factors in Cancer Initiation, Progression and Chemotherapeutic Drug Response

  2014cites this paper