Kinetics and clonal restriction of the anti-dinitrophenyl antibody response to dinitrophenyl-6-amino-caproyl-L-tyrosine-azobenzene-p-arsonate in guinea pigs.

The anti-DNP responses in guinea pigs to the small bifunctional antigen DNP-SAC-RAT and to DNP-protein were compared. The response to DNP-SAC-RAT is more restricted both in terms of the anti-DNP titers reached in serum and of the number of DNP specific clones expressed. Priming with DNP-SAC-RAT led to an accelerated secondary response reaching similar levels of anti-DNP antibody as in the primary response. In sera showing restricted clonal patterns by isoelectric focusing, it was found that once a clone dominated the anti-DNP response it remained stable during the primary response and was the only one to reappear after secondary stimulation.

• Publication year

  1974

• Venue

  Journal of Immunology

• Publication date

  1974-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.112.3.883PMID 4130113
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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